Kalluri Lab

Grateful to @break_cancer @lustgartenfdn and @UTMDAnderson for funding this work. Check it out now in @embojournal

Now online ➡️ we identify CDK8 as a resistance mechanism across several Kras inhibitors including daraxonrasib. Targeting CDK8 alone can overcome resistance and sensitize tumors to checkpoint immunotherapy with curative outcomes ‼️ link.springer.com/article/10.103…

In @embojournal from @KalluriLab & @mcandrews_kate @UTMDAnderson dissecting a novel mechanism of resistance to KRAS inhibitors: CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in #PancreaticCancer link.springer.com/article/10.103…

We had a blast 💥 catching up on paper celebrations. Three recent lab publications, by @krishnaniyer199 in @Cancer_Cell, @Bingruilii in EV, and @rkalluriMDPhD in @ImmunityCP, were added to the wall. 🍾

Proud lab moment! We’re happy to announce Raghu’s election to the @aimbe College of Fellows 🤩 Congrats, Boss!

Houston, we have a solution! @SaurLab and @Bingruilii are on the scene at NASA 🚀 Glad to have Dieter with us in Houston for a terrific week of science!

Team False Positives made a comeback! The lab trivia team came out on top at tonight’s trivia in the Village! Clutch performance by the @RiceBIOE @RiceSSPB @RiceECE PhD Students.

We’re honored to be part of the @break_cancer Conquering KRAS TeamLab, highlighted in @TheCancerLetter this week. Amazing work by our colleagues and friends, with more results on the way!💡 cancerletter.com/conversation-w…

@KeChengLab @ScienceMagazine Super cool! Congrats Kaiyue and Ke

Congratulations to Kaiyue Zhang on the publication @ScienceMagazine. In the paper, we built an “RNA factory” on muscle for heart repair. science.org/doi/10.1126/sc…

We run on coffee, curiosity, and more than two dozen languages (mostly real)! 🌎 💬 🗺️🧭📍

Raghu delivered the plenary keynote lecture on biology and function of exosomes in cancer at the SPARC cancer research conclave on Exosomes in Cancer in Vishakhpatnam, India. Discussion after lasted 45 minutes!

We asked AI to summarize the 2024 Meeting of @AAEV_org, but it fell short of expectations. We wrote about our experience with multiple LLMs, and their performance identifying speakers, citations and terminology. We humans are still in business, for now. sciencedirect.com/science/articl…

These researchers and institutions are bringing home 2026 Hill Prizes. houston.innovationmap.com/hill-prizes-20…

Today the lab celebrated the well-earned retirement from @MDAndersonNews of our IT and Tech Support HERO 💪, Gil. Every discovery, publication, and therapy emerging from the lab is credited in part to Gil, our silent author, without whom none of it would be possible 💙

💡Curious about the origins of iExosomes? ➡️ Read about the decade-long journey from concept to clinical trial, over on the Ras Dialogue Blog by Frederick National Laboratory

📣Our secret is OUT! Cancer keeps us busy, but one experiment led to another…and we invented an EYE DROP therapy for AMD! Thrilled to share that this work has been awarded the @TAMESTX 2026 Hill Prize in Medicine Our iEV eye drops are poised to disrupt the industry standard!

These Houston inventors are leading their fields, from AI to chemistry to cancer research. houston.innovationmap.com/nai-2025-fello…

🎉 Congrats to Kalluri Lab Alum @jackie_parchem for receiving a Young Physician-Scientist Award from @the_asci. Dr. Parchem is an Associate Prof @UTHealthHouston, Maternal Fetal Medicine and preeclampsia specialist…a field with few clinician scientists. Proud day for the lab!

@UTPoliceHouston The best in the business 🤩

Behind every holiday is an officer on duty. We appreciate our officers who work holidays year-round to keep our community safe. Wishing everyone a safe and happy holiday season. #UTPolice

✅ Clinical validation of our 2014 discovery Hedgehog inhibitor primes PDAC TME to leverage immunotherapy as 1st line treatment in metastatic pancreatic cancer. Trial led by @DrMhidalgo & @Perlmutter_CC 🙌 medrxiv.org/content/10.648…