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timofran
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Very few parts of my job @UMichSurgery are more meaningful to me than mentorship. It was so special today to be recognized for my mentorship and more importantly for my mentee @BGriffithMD receiving the outstanding resident research award for his seven amazing years of work.


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@am_elhossiny @Pasca_Lab @Aiims1742 @UMich @UMICHpancreas Great synopsis of years worth of work! Congrats Ahmed!
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8/ Huge thanks to my mentors @Pasca_Lab, @timofran1 , Eileen Carpenter, Elana Fertig, @Aiims1742 & Arvind Rao, and the collaborators across @UMich and the support from @UMICHpancreas. And of course, to the organ donors who made this possible 🙏
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🧵 Excited to share that the second half of my PhD is now published in @CancerDiscovery! 🎉
"Asynchronous evolution of epithelium and stroma differentiates precursor lesions from pancreatic cancer"
More details on our ground breaking findings 👇
Cancer Discovery@CD_AACR
Now online: Asynchronous evolution of epithelium and stroma differentiates precursor lesions from pancreatic cancer doi.org/10.1158/2159-8…
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How do precancerous pancreas lesions turn into pancreatic cancer? A new study from @UMICHpancreas finds that while the lesions express many of the same genes as tumors, the microenvironment remains like the normal pancreas. michmed.org/AmVwg @UMichSurgery @CD_AACR

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We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is fortunately rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment. @umichmedicine @UMRogelCancer
aacrjournals.org/cancerdiscover… @CD_AACR

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So proud of @RashmiJKumar for her fantastic presentation representing @UMICHpancreas and @UMichSurgery at the 2026 Michigan American College of Surgeons Meeting taking home awards for top cancer and top overall presentation!


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New research from our team published in @CD_AACR shreds light on how PanIN lesions evolve into pancreatic cancer. This could help us ID people at higher risk of cancer or even potentially stop malignant transformation: michmed.org/AmVwg @Pasca_Lab @timofran1 @CD_AACR

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Very excited to share this work towards understanding why some precancerous lesions progress while others do not.
U-M Rogel Cancer Center@UMRogelCancer
New research from @UMICHpancreas sheds light on how early pancreas lesions become cancerous. The findings published in @CD_AACR help explain why many precursor lesions never develop into pancreatic cancer: michmed.org/AmVwg @Pasca_Lab @timofran1 @Aiims1742
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It’s never too to early to develop a passion for research! Congrats to Guy and his mentor Harrison for an award winning poster at the 2026 @UROPumich symposium.

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Highlighting again, Thank you Dr. Rashmi Kumar for representing our team in the amazing clinical and research work you do! @UMichSurgery
youtube.com/watch?v=AvIZ6j…

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Fortunate to share in the visit with translational science superstar, Dr. Jen Jen Yeh, Director, UNC Lineberger Pancreatic Cancer Center of Excellence. Dr. Yeh was the Dept. of Surgery Grand Rounds speaker on April 16th hosted by Dr. Frankel and the Center for Basic and Translational Science (CBATS). @timofran1 @LyssiotisLab @Pasca_Lab @UMichSurgery @Fil_Bednar



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So proud of @BGriffithMD for a fascinating chief talk highlighting the amazing accomplishments during his academic development time. The future is bright for academic surgery. @UMichSurgery @UMICHpancreas @UMRogelCancer @UnivSurg @Pasca_Lab




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Go Blue! We love watching our trainees shine. Rashmi Kumar, MD, PhD presenting at the Society of Surgical Oncology Conference. Single-Cell Profiling of the Pancreatic Adaptive Immune Microenvironment with Inducible KRAS Activation: Understanding Therapeutic Vulnerabilities. Dr. Kumar is a Dept of Surgery resident and valuable colleague within the Frankel and Pasca di Magliano research labs. #SSO2026 @timofran1 @LyssiotisLab @Pasca_Lab @UMRogelCancer @UMichSurgery

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We are looking forward to turning out and partnering in HOPE with you! See you April 25th in Detroit! @PanCANMichigan @timofran1 @UMRogelCancer @LyssiotisLab @Fil_Bednar
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I am honored to serve as the new Director of the @Perlmutter_CC. Thanks to Dean/CEO Alec Kimmelman @nyulangone for this opportunity. Excited to partner with @JohnPLeonardMD & the entire PCC community as we build our next exciting chapter. Lots to come!
prnewswire.com/news-releases/…

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We are excited to announce that Jamie Mills, MD, PhD has been named the inaugural Rogel and Blondy Center for Pancreatic Cancer Emerging Scholar in Clinical Trials. Dr. Mills’ role will focus on developing investigator-initiated clinical trials as well as increasing participation in existing cooperative and industry sponsored trials. Marking a huge win for our patients and our team!
Dr. Mills joined faculty at the University of Michigan in 2025 after completing her fellowship in Hematology & Medical Oncology. She specializes in medical treatment of cancers of the GI tract, including pancreatic and is heavily involved in studying the epigenetics of pancreatic cancer. @timofran1 @UMRogelCancer @Pasca_Lab @LyssiotisLab @Fil_Bednar @EvanGlazerMD

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Happy Holidays from our family to yours! Wishing for blessings of Health, Happiness and Hope in 2026! @UMRogelCancer




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Such a talented individual and amazing body of work!
Rogel and Blondy Center for Pancreatic Cancer@UMICHpancreas
Today we celebrated Ahmed Elhossiny who defended his thesis, Leveraging single-cell and spatial transcriptomics data to decode pancreatic cancer progression. So proud! Congratulations Dr. Elhossiny! @Pasca_Lab @LyssiotisLab @timofran1
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A study, led by Timothy Frankel (@timofran1), explains why smokers have a higher chance of developing pancreatic cancer. They found a specific cell that responds to environmental toxins such as those found in cigarettes.
Learn more: michmed.org/eQgdQ.
@UMICHpancreas

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