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Jeremy Schmit
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Jeremy Schmit
@SchmitBiophys
Emergent behavior in biomolecules. I study how biomolecules interact. Not just 1 or 2 molecules, but moles of them.
Manhattan, Kansas Katılım Eylül 2008
402 Takip Edilen540 Takipçiler
Thrilled to be a part of this collaboration!
Kresten Lindorff-Larsen@LindorffLarsen
How do proteins mis-fold? New preprint led by @JAunstrup from @alexander_buell @biophysics_dtu group with MD simulations by Abigail Barclay. We combined experimental measurements of Φ-values with restrained simulations to study the TSE for fibril growth doi.org/10.26434/chemr…
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Jeremy Schmit retweetledi
Congrats to the lab and collaborator @SchmitBiophys ! (more soon!) Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units | PNAS pnas.org/doi/10.1073/pn…
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Jeremy Schmit retweetledi
Circuit Topology Approach for the Comparative Analysis of Intrinsically Disordered Proteins #IDP #compchem #cheminformatics
pubs.acs.org/doi/10.1021/ac…
@VSheikhhasani @laurenswh @SchmitBiophys @AlirezaMashaghi
Vol63 Issue8 #JCIM #Bioinformatics
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Jeremy Schmit retweetledi
Fun collaboration with @SchmitBiophys - I learnt a lot in process and our discovery opens the door for many more experiments!
The Science of Parkinson's@ScienceofPD
New paper from @PernillaWittung et al explores elongation kinetics of #Parkinsons-associated α-synuclein with Thioflavin-T fluorescence & solution state NMR spectroscopy, & finds elongation of synuclein amyloids involves distinct kinetic regimes cell.com/biophysj/fullt…
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Jeremy Schmit retweetledi
Interested in designing ligands to optimize phase separation of scaffolds in condensates? With @SchmitBiophys, we dived into this problem using designed tetraubiquitin ligand hubs, and combined theory and experiment to uncover molecular rules - learn more: biorxiv.org/content/10.110…
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@ruthhook_ More like Robin Hood, tbh, although I see how you had to claim the eponym.
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also if you ever need a paper behind a paywall that's not on scihub- dm me- I have journal access, a family of NAS professors who raised me to hate elsevier, & a friend circle of researchers who all support open science- am more than happy to be captain hook the science pirate
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Jeremy Schmit retweetledi
Missed The @FASEBorg Nuclear Bodies Conference this year? Read the Meeting Report in the FASEB Journal doi.org/10.1096/fj.202…; then sign up to be notified of the next conference, bit.ly/37LRHog.
#NBSRC22 #GeneControl #RNAmetabolism #PhaseSeparation #Genomics #Cancer
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Thanks to @OASaleh and Fyl Pincus for a great visit to UCSB. And to all the physics and BMSE students for their fantastic questions. It's amazing how much the place has grown since I was there!
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Afternoon fun at the Protein Folding #GRC with Ed O'Brian, @fried_lab, and @SulkowskaL. Not shown: @davethirum
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Getting an early start on #GRC Protein Folding Dynamics. Looking forward to seeing everyone in Ventura!
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@RangachariL Soon (hopefully)! As soon as I get the file from @IDPseminars I'll post it.
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Thanks so much for the opportunity to speak!
IDPseminars@IDPseminars
@SchmitBiophys showed how the network structure encode the functional properties of condensate to give unique structure/function properties. He also reminded us that about the limitations of condensates as reaction crucibles: Slow diffusion. ⬇️ doi.org/10.1101/2022.0…
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@DavidWSanders2 A common thread in some of my best papers is that I look back and marvel at how naive I was. I'm not sure I would have attempted them if I knew what I know now.
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Today I learned that the more you know about a topic, the more difficult it is to communicate your scientific rationale. Well this certainly explains a lot about academia.
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Jeremy Schmit retweetledi
Assistant professors wanted! Come to join us at Johns Hopkins School of Medicine Biophysics! apply.interfolio.com/110326
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@alain_andre @SpruijtLab @OodlesOfYewdall @KnowlesLabCamb came to the same conclusion with poly-A condensates. Interesting that you are seeing it more on the NPM1 side than with the RNA.
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Have you ever wondered how #crowding can influence #PhaseSeparation? Our (@SpruijtLab @OodlesOfYewdall ) latest results indicate that PEG is not an ideal crowder and induce phase separation of NPM1-rRNA #condensates by co-condensation. (1/4)🧵
biorxiv.org/content/10.110…
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Jeremy Schmit retweetledi
After a brief break, we are happy to announce our program for the coming months featuring:
@BoeynaemsSteven, @DrJoanShea @ioana_ilie_UvA, @SchmitBiophys, @savitski_lab, @Nicolas_Fawzi, @daviddesancho, Frans Mulder, @jrkumita and Christine Keating.
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Special thanks to lead author @PhanBioPhys for doing all the hard work and @HalfmannLab for helpful discussions. 9/9
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Our result explains co-aggregation data in length variants. Since amyloid nuclei only involve a few amino acids from each chain, they are relatively insensitive to sequence or length differences. Differences are more important during elongation. 8/9
science.org/doi/full/10.11…
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Announcing the latest from the Schmit group: a special treat for the amyloid afficionados in the Twitterverse (I know you're out there!) A look at nucleation of the aggregates driving diseases like Alzheimer’s and Huntington’s. 1/9
doi.org/10.1016/j.bpj.…
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