Schug Lab
202 posts
Schug Lab
@SchugLab
The Schug Lab studies cancer metabolism with a focus on fatty acids. Our favorite fatty acid...acetate! Reach out if you’re interested in joining us!
Philadelphia, PA Katılım Ağustos 2019
482 Takip Edilen483 Takipçiler
New paper alert! Huge congrats to my graduate student @jn_velascosilva on his first author publication in physiological reports physoc.onlinelibrary.wiley.com/doi/10.14814/p… 1/n
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Schug Lab retweetledi
NEW: Today, I’m releasing a Surgeon General’s Advisory on the causal link between alcohol consumption and increased cancer risk. Alcohol is the 3rd leading preventable cause of cancer in the U.S., contributing to about 100,000 cancer cases and 20,000 cancer deaths each year.
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Happy to announce our collaboration with @Tcellogic on metabolic features of exhausted T cells is now out in @ScienceMagazine. TL;DR they can't use acetate to fuel their function. Great work by Shixin Ma and Mike Dahabieh. science.org/doi/10.1126/sc…
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Our work on metabolism of quiescent cells! A bit of a new area for us in collaboration with the Buckanovich lab
Molecular Metabolism@MolMetab
New research reveals that #acetate drives quiescence in ovarian #cancercells by boosting ACSS2-mediated acetyl-CoA production. High ACSS2 levels are linked to poor patient outcomes and #chemoresistance. Targeting ACSS2 could enhance treatment response! 🔗sciencedirect.com/science/articl…
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Thanks to support from @TheVFoundation, @NanZhangWistar and @AuslanderNoam have been named as V Scholars and awarded $1.2 million in grant funding to support research that aims to improve existing cancer therapies. Our story: bit.ly/4gudEpE
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Excited to share our latest study on ACSS1 and acetate metabolism in cancer, which was spearheaded by two graduate students in the lab. Stay tuned for more exciting news from the Schug Lab!
Cell Reports@CellReports
ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis dlvr.it/TGKcML
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A huge congratulations to Jesse Velasco who successfully defended his PhD thesis today! As my first graduate student this one is really special. Thank you Jesse! @UofUBiochem
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@FrezzaLab Thank you Christian! We should definitely catch up one of these days
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My baby girl came on Monday night and closing the week with a first author paper from @DrRGJonesLab ! What a week!! Many thanks to everyone for all the efforts to get this paper out!!
Journal of Experimental Medicine@JExpMed
Kaymak, Watson @DrRGJonesLab @VAInstitute and colleagues show that production of cytosolic acetyl-CoA by ACLY and ACSS2 links CD8 T cell metabolic state and effector function through effects on #chromatin accessibility. hubs.la/Q02Lzc7r0 #Metabolism #LymphocyteBiology
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No amount of alcohol is safe but the risk of limited consumption is limited but dictated by underlying conditions. This is an excellent summary of meta-analyses @nytimes nytimes.com/2024/06/15/mag…
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New preprint from the lab is online! The product of a stellar collaboration with @Muir_Lab, we explore a chemically defined physiologic media formulation based of the metabolite of tumor interstitial fluid (TIF, or “tumor juice”) and its effects on T cell function! A brief 🧵1/
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Meet Nathaniel W. Snyder @mzspectrum Winner of the 2024 Chemical Research in Toxicology Young Investigator Award! Read our interview here 🔗 go.acs.org/9HM
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Happy to report that our paper, where we grapple with the mystery of ACLY splice isoforms, is finally out!
jbc.org/article/S0021-…
@WellenLab @MarmorsteinLab
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🔬 Excited to share @SchugLab’s latest findings at #ASMS2024! Join me at the poster session where we’ll delve into:
1. Targeted Metabolomics.
2. FASN (Fatty Acid Synthase) and fatty acid biosynthesis.
3. Coenzymes A, malonate, and succinate.
4. Mitochondria (should I add ‘powerhouses’?).
➡️ ThP133, Thu, June 6, 10:30 am ⬅️
See you there! 🌟🧪📊
#TeamMassSpec
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Happy to share our new paper in print today in @ScienceAdvances exploring nutrient utilization by CD8 T effector cells in vivo using infusion of 13C tracers. Great work by Eric Ma, Mike Dahabieh and collaborators at @VAInstitute and @AgiosPharma. science.org/doi/10.1126/sc…
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