Muir Lab

We at @PanCAN were pleased to see the release of the updated @NCCN Pancreatic Adenocarcinoma Guidelines.

I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara! We took a first principles approach to evaluating #ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. biorxiv.org/content/10.648…

Announcing our 2026 CMH Postdoctoral Rising Stars Symposium on Wednesday, September 2! To apply for this opportunity, scan the QR codes on the flyer or visit our track links: Metabolism (shorturl.at/rjV1N) and Health Behaviors (shorturl.at/ayq8p). Help spread the word

Thrilled to share our work in press @jclinicalinvest where we modernize a hallmark experiment originally performed by the Coris by performing intra-operative metabolite sampling in lung cancer patients jci.org/articles/view/…

Excited to announce that registration is officially open for #METPHYS2026! All meeting details can be found here: sablesys.com/metphys-the-me…

Out today 🙌 new work from the lab in which we show that p53-driven senescence enables phospholipid headgroup recycling to help sustain the increased synthesis of membrane phospholipids of senescent cells #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4155…

I love this concept. Although framed around #aging research, I think it can extend beyond that. We can use a synthetic approach, to study basic principles of cell biology and potentially mitigate human disease by engineering unique bacterial enzymes. science.org/doi/10.1126/sc…

New! Online now: A metabolic atlas of mouse aging dlvr.it/TPSYYS

New @CR_AACR study by @Cosimo_Commisso The Aging Microenvironment is a Determinant of Immune Exclusion and Metastatic Fate in #PancreaticCancer aacrjournals.org/cancerres/arti…

🗽Save the date! March 24, 2026 Cancer Metabolism and Signaling Symposium @NYASciences co-organized by @LyssiotisLab @RichPossemato Speakers: @lab_manning @bensahralab @MarcusDGon @airdlab @KanarekNaama @JaviGBermudez @SantoshVardhana Josh R, Erika P +short talks from abstracts!

Happy to share our new review (featuring Joe Longo and McLane Watson) on how T cells use nutrient allocation to optimize immune responses. @VAIMetabolism @VAInstitute sciencedirect.com/science/articl…

Big news from the #Glytsoulab today!✍️Our research on drug resistance in leukemia is published in @ScienceAdvances. Targeting OPA1 can help overcome therapy resistance in AML, including the most challenging cases. 📖 science.org/doi/10.1126/sc…

@glytsou @ScienceAdvances Congrats! Very cool!

Our new work in @Cell_Metabolism by @ArtemAKhan describes three new SLC transporters, including SLC25A45, a mitochondrial transporter for methylated amino acids that is essential for carnitine synthesis and fasting adaptation. @RockefellerUniv cell.com/cell-metabolis…

This cool @ScienceMagazine paper links extracellular pH milieu (acidosis) to an intra-cellular oncogenic signaling pathway & metabolic rewiring in #PancreaticCancer. Acidosis orchestrates adaptations of energy metabolism in tumors science.org/doi/10.1126/sc…

Wonderful talk by @DebVendramini @HenryFordHealth on adaptation & plasticity of the stromal and #CancerAssociatedFibroblasts microenvironment in driving immune suppression in #PDAC #AACRPan25 @RAFrancescone

Location, location, location! Now out in @NatureCancer, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation in pancreatic cancer as a clin. relevant example: nature.com/articles/s4301…. (1/3)

@OlzmannLab @Aiims1742 @ColinSh21573670 Thanks James!

@Muir_Lab @Aiims1742 @ColinSh21573670 Exciting work! Congrats! 👏

Super excited to share our new preprint from @ColinSh21573670 on how the tumor microenvironment causes drug resistance in pancreatic cancer: biorxiv.org/content/10.110…

@schwoerersimon Congrats!!

Excited to share the lab’s first pre-print! Here we investigate how #nutrient availability regulates #ECM composition, mechanical properties and biological activity. biorxiv.org/content/10.110…