Sergio Novi

In 2025, JAMA Otolaryngology marked its centennial with a 7% increase in submissions, an Impact Factor of 5.6, and >6.3 million article views. Read “JAMA Otolaryngology–Head & Neck Surgery—The Year in Review, 2025,” by Jay F. Piccirillo, MD. ja.ma/3Pcb0ga

This review summarizes recent deep learning advances in otolaryngology, including diagnostic models with expert-level accuracy for nasopharyngeal carcinoma and otologic pathology. ja.ma/4jPVxxq

@vsmzin Parabens e boa sorte

Feliz em representar uma organização desse tamanho, ao lado de pessoas cujo estilo de jogo sempre admirei. Pode ter certeza de que vou entregar a minha melhor versão aqui. Lutei muitos anos por uma oportunidade como essa, e ela finalmente chegou. Estou muito feliz em fazer parte disso. Agora é trabalhar, porque temos pouco tempo para treinar e disputar o próximo campeonato. E agradecer também à torcida, que já me apoiava mesmo antes de eu entrar. #GOpaiN @paiNGamingBR

@bryan_johnson Out of curiosity, you mentioned that your body largely operates at elite 18-year-old levels. If you were to take some time off the protocol, how would your body respond? Would the rate of aging temporarily accelerate beyond that of an 18-year-old?

I’m going to try and achieve immortality by 2039. One year of time passes and I remain the same biological age. I invite you to join me. The search for the fountain of youth is the oldest story ever told. It’s been the dream of dreamers for millennia but always painfully out of reach. For the first time in the history of life on earth, in just the past 24 months, the window has opened for a conscious being to realistically strive for this goal. It is an absolutely insane moment. We currently do not know how 2039 immortality will be achieved. There are new, promising therapies that can turn back the clock decades, but they’re buggy. Sometimes they mistakenly cause cancer. We gotta fix that. But we know immortality is possible because nature has already solved it. This isn’t a physics problem like trying to travel faster than the speed of light, it’s a biological engineering problem that evolution has cracked multiple times. The freshwater hydra constantly regenerates its own cells and doesn’t succumb to senescence. It is effectively ageless. The "immortal jellyfish" (Turritopsis dohrnii) can revert its cells back to a youthful state and restart its life cycle indefinitely. Lobsters produce an especially active form of an enzyme called telomerase that preserves their telomeres and keeps their DNA from degrading as they age. We need to port the software to humans. 2039 is a reasonable target because of the accelerated, AI-driven rate of innovation. AI is morphing from assistant to scientist.  It is powering current researchers with previously unimagined capabilities to enhance discovery and development. That, coupled with enhanced biomarker measurement, creates a closed-loop system of improvement that will speed things up dramatically. This is what I’ve been doing for six years. As crude as longevity technology is today, the improvements I’ve personally seen are stunning. I started as a worn-down, inflamed, aged 42 year old who’d broken himself on the rocks of American food slop and entrepreneurship martyrdom. Six years later, my body largely operates at elite 18 year old levels. That includes my cardiovascular system, fertility, strength, and hormones. Not all is well though. I have mild to moderate hearing loss in my left ear that we can’t fix and my brain is anatomically age 42 (I’m 48). Still, unreal results. My team and I did this by following the scientific method. We measured the biological age of every organ. We referenced the best scientific evidence on how to slow aging and rejuvenate.  We methodically completed these protocols and measured again. Rinse and repeat. We could do so much more and faster if we had better measurement and better therapies. Both of which are cooking all over the world right now. To speed things up now, I’m currently having thousands of Bryan Johnson organ clones built in a dish. This will allow me to test drugs and other molecules against my biology to accelerate learning and save my body from potential mishaps. Yes, we’ll make mistakes. Hopefully they won’t be fatal. And of course there’s always bad luck to contend with. But I trust in fate and I believe that destiny is going to grant the human race the pleasure of achieving the ultimate: immortality. While immortality would certainly be cool, the real (secret) objective is to focus our collective attention on a positive goal. Something that helps us feel hope and excitement for the future. I personally love the idea of having a child-like mind, 18-year-old physical vibrancy, and a lifetime of wisdom. This 2039 goal is as much about AI as it is about us humans. It’s about how we survive giving birth to superintelligence. It’s kind of a big deal. We haven’t done it before. A lot can go wrong. I figure that one of the best ways to improve the probability that we build safe AI, and don’t kill each other in the meantime, is to transform our shared aspirations from yolo to don’t die. Right now, we are a suicidal species. We do all kinds of really primitive shit. We unnecessarily kill ourselves with what we eat and how we live our lives. Companies make profits from killing other people with their products. We trash the only home we have. We celebrate these things as virtue.  It’s really fucked up and backward. Soon enough we’ll realize just how infantile we are right now. The 2039 goal points us in the right direction. To say yes to life and no to death. Defiance even. If you’re interested in doing this with me, I’ll continue to share everything I do for free. I’m also going to build this out in Blueprint. We’ll help you do exactly what I’m doing, at a fraction of the cost and effort, alongside an aligned and motivated community. I think this is the coolest goal imaginable. I find it hard to believe that of all the people who’ve lived, it’s us who get the opportunity to have this moment. I pray that we have the courage to appreciate the sacredness of our existence. I pray that we will be brave enough to defend her amidst the onslaught of all the forces that would try to end her. We don’t know, but we may be the only intelligent life to exist in our corner of the galaxy. I pray we will be warriors, caretakers and stewards of existence and honor the gift that has been bestowed on us.

Congrats to @SergioNovi and @NithyaNavarat for this review of deep learning in otolaryngology. Newer models ≠ better clinical outcomes.

This review summarizes recent deep learning advances in otolaryngology, including diagnostic models with expert-level accuracy for nasopharyngeal carcinoma and otologic pathology. ja.ma/49SH9Bu

🤩We’re thrilled to launch the NIRx Learning Center, your new hub for #fNIRS support, training, and fNIRS applications! Supporting your research with accessible, expert knowledge. 🔗 nirx.net/technical-supp…

@Lesealll @Izak_Font @padraonota7 Nesse caso o problema tinha sido dentro da fábrica por um método de resfriamento que nao era permitido.

@Izak_Font @padraonota7 Engraçado que não tiveram problema em divulgar a marca da cerveja Backer em 2020

Por que ninguém fala as marcas das bebidas com metanol? O gin eu sei que foi Tanqueray

Our new paper in AJRCCM shows how AI & 5.5M+ MRI slices from 12K kids can predict brain outcomes in children who snore. Smaller upper airway volume = lower cognition + less gray matter. #ENT #PedsENT #DeepLearning #MedicalAI atsjournals.org/doi/abs/10.116…

Excited to share our new paper using fNIRS to investigate the neural correlates of sleep-disordered breathing in children! 86 patients. A big deal for #fnirs! More to come. Stay tuned!

@IliasTachtsidis @isott2025 @AmalIsaiahMD

Very excited to announce the @isott2025 program isott2025.com/index.php/prog… You still have time to register and to join us at the Meeting of the International Society of Oxygen to Tissue in Greece.

Great talk by our rising chief @sophiaeuddin at @UMMC ENT’s annual Blanchard Kleiman Lectures! A great spotlight on how we’re using #fNIRS to assess executive function in children with SDB.

@ZabucaRodrigo @papini_antonio @george1BR2 Nessa conta, você acabou fazendo a correção do valor duas vezes. Se valia 850 mil no valor corrigido, precisaria dividir pelo valor do dólar atual para fazer a conta em dólar. Se não, você corrige duas vezes o valor. Tmj

Você comprou seu imóvel em 2005 por R$ 850 mil em valores de hoje. Considerando a inflação e as variações do câmbio, vamos estimar o valor em dólares na época da compra. Em 2005, o dólar estava, em média, na casa dos R$ 2,50 (ajustado aproximadamente). Isso significa que, na época, os R$ 850 mil de hoje equivaleriam a algo próximo de US$ 340 mil (850 mil ÷ 2,50). Hoje, em 2025, com o imóvel valendo R$ 1,6 milhão e o dólar a, digamos, R$ 5,50 (uma estimativa razoável com base nas tendências recentes), esse valor se traduz em cerca de US$ 290 mil (1,6 milhão ÷ 5,50). Olhando assim, em dólares, você pagou US$ 340 mil e hoje ele vale US$ 290 mil. Isso mostra que, em termos de poder de compra global, houve uma perda de valor. Claro, você morou no imóvel por 20 anos, o que tem um valor intangível enorme — segurança, lar, memórias —, mas financeiramente, em uma moeda forte como o dólar, o imóvel não se valorizou tanto quanto parece em reais. A desvalorização do real frente ao dólar mascara essa realidade. Eu já fui como você, sabe? Apaixonado por imóveis, achando que eram o investimento perfeito, uma garantia de futuro. Cresci ouvindo que "imóvel nunca perde valor", que é "patrimônio para a vida". Mas com o tempo, comecei a enxergar que essa idolatria cega por tijolo e concreto pode nos enganar. Imóveis têm custos altos — manutenção, IPTU, reformas —, e a valorização nem sempre acompanha outras opções, como investimentos financeiros ou até a inflação global. No seu caso, o "lucro" em reais existe, sim, mas ele é ilusório quando olhamos o cenário maior. A reflexão aqui é: não podemos nos prender só ao que o coração sente pelo imóvel ou ao que os números em reais nos dizem à primeira vista. Ele te deu um lar por 20 anos, e isso é valioso, mas como investimento puro, talvez não tenha sido o pote de ouro que imaginamos. Acho que o segredo é equilibrar: valorizar o que o imóvel nos dá de qualidade de vida, mas sem fechar os olhos para outras formas de fazer o dinheiro trabalhar por nós,o que não é Fácil!

Tem coisa mais patética do que a mentalidade do brasileiro médio?

@FalleNCS Time melhorou demais! Foco total! Boa sorte nas próximas competições

É amigos não conseguimos hoje jogar na mesma altura que jogamos alguns dias atrás - ambiente novo para alguns e adversário que hoje foi muito superior Gostaria muito de ter conseguido entregar uma performance melhor pra vcs que estavam aqui presente e em casa - sinto muito por isso Obrigado a todos pelo apoio absurdo sempre… reconforta muito a todos nos Conseguimos bons avanços nessa competição. Seria maravilhoso ter avançado ainda mais e brigado pelo título mas teremos que nos contentar com as boas exibições da fase de grupo.

@FScholkmann @karnig_kazazian Thanks for sharing it @FScholkmann

fNIRS: A novel tool for detecting consciousness after acute severe brain injury pnas.org/doi/10.1073/pn…

Want to know how you can use functional near-infrared spectroscopy to detect consciousness? Let us show you (no paywall). @karnig_kazazian @MatthewKolisny1 @DebickiDerek @lorettaenorton @SergioNovi pnas.org/doi/10.1073/pn…

@Murilim4i20 @oficialoplano @GoDustyRoots Começou

@oficialoplano @GoDustyRoots Tira o boltz que ainda da tempo

Queda abalou um pouco... Não conseguimos voltar a tempo Perdemos de 9x13 pra @GoDustyRoots 🥲 Obrigado a torcida de todos galera ❤️ Amanhã teremos a segunda chance! #RUMOÀGLORIA

@Eu_Pietroo41 @oficialoplano @GoDustyRoots Começou

@oficialoplano @GoDustyRoots BOLTZ EH HORRÍVEL!

Amazing work led by Dr. @lorettaenorton