Sharp Laboratory

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Sharp Laboratory

Sharp Laboratory

@Sharp_Lab

Assistant Professor @USFHealth, Cardiovascular Scientist, #Cardiometabolic Disease, #HeartFailure @ECI_ISHR https://t.co/0hfSNN8buc

Katılım Temmuz 2023
190 Takip Edilen103 Takipçiler
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Sharp Laboratory
Sharp Laboratory@Sharp_Lab·
@EricTopol Reta is the next breakthrough. Synergy btw GCGR agonist and anti-obesity effects of single/double-G is profound. Reta in Ms/Rt obese HFpEF models is promising! Differentially regulating PPAR in an organ specific manner. Reta > PPAR quintuple pan-agonism.
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Eric Topol
Eric Topol@EricTopol·
Retatrutide, a triple receptor drug for GLP-1, GIP, and glucagon, is the most powerful weight loss drug yet. A significant issue is too much weight loss among the trial participants. New randomized trial results announced today with 28% body weight loss. gift link nytimes.com/2026/05/21/sci…
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Sharp Laboratory
Sharp Laboratory@Sharp_Lab·
@DanielJDrucker Reta is the next breakthrough. Synergy btw GCGR agonist amplifies the anti-obesity effects of single/double-G. Reta in Ms/Rt obese HFpEF models is wow! Differentially regulating PPAR in an organ specific manner. Reta>PPAR quintuple pan-agonism. Reta metabolic flexibility king.
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Daniel J Drucker
Daniel J Drucker@DanielJDrucker·
In SURPASS CVOT tirzepatide was associated with a reduced risk of major kidney events driven by a reduction in new-onset macroalbuminuria in PPL with low-to-moderate-risk CKD #T2D and slowed decline in kidney function in high-risk chronic kidney disease. thelancet.com/journals/landi…
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Eric Topol
Eric Topol@EricTopol·
In people with HFpEF (heart failure with preserved ejection fraction) and severe obesity, there is a heart muscle cell defect with sarcomere hyper-phosphorylation. Besides weight loss, sarcomere enhancers (not yet studied) may help. @ScienceMagazine science.org/doi/10.1126/sc…
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Circulation
Circulation@CircAHA·
The rapidly evolving landscape of incretin-based therapies, including GLP1 agonists, necessitates rethinking trial design. Authors present challenges of placebo-controlled trials & potential ways to limit placebo exposure ahajrnls.org/4t0TrPa
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Circulation
Circulation@CircAHA·
Multi-organ physiologic deficits during exercise and their metabolic signatures predict incident HFpEF and HF outcomes ahajrnls.org/41k5Hy2
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ThePeptideList
ThePeptideList@PeptideList·
Everyone's talking about retatrutide for weight loss (28.7%). Almost nobody's talking about what it does to your liver. More than 80% reduction in liver fat. Over 90% normalization rates. In a body composition substudy from the Phase 3 program. 100 million Americans have fatty liver disease. Most don't know it. There's no FDA-approved treatment for it besides "lose weight and hope." Retatrutide's glucagon receptor activation appears to directly target hepatic fat metabolism not just as a side effect of weight loss, but as a primary mechanism. This isn't a weight loss drug that happens to help your liver. It might be a liver drug that happens to cause weight loss. Phase 3 weight loss data drops first half of 2026. Watch this space.
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Eric Topol
Eric Topol@EricTopol·
A new review of the GLP-1 receptor drugs @NEJM nejm.org/doi/full/10.10… surprisingly, the word inflammation only appears once, in this diagram
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Pablo Corral MD
Pablo Corral MD@drpablocorral·
👉 Metabolic Disorders and Cardiovascular Disease: Key Insights 👆 A recent ESC scientific statement highlights the central role of metabolic dysfunction in cardiovascular disease and the therapeutic implications of emerging cardiometabolic therapies. 👆 Key points: 📍 Cardiovascular disease is increasingly driven by metabolic dysfunction—obesity, type 2 diabetes, and dyslipidaemia act synergistically to accelerate atherosclerosis, heart failure, and arrhythmias. 📍 Metabolic disease disrupts myocardial energetics, promoting metabolic inflexibility, mitochondrial dysfunction, oxidative stress, and lipotoxicity. 📍 Modern cardiometabolic drugs provide benefits beyond glucose lowering. SGLT2 inhibitors and GLP-1–based therapies improve cardiovascular outcomes through pleiotropic mechanisms. 📍 Atherogenic risk extends beyond LDL-C, with triglyceride-rich lipoproteins and Lp(a) contributing to residual cardiovascular risk. 📍 Future progress will require a systems-biology approach, integrating multi-organ mechanisms, multi-omics data, and translational research. 👆 Bottom line: Cardiovascular disease should increasingly be understood as a systemic cardiometabolic disorder rather than an isolated vascular pathology. 🔗 Open Access academic.oup.com/eurheartj/adva… @society_eas @escardio
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Eric Topol
Eric Topol@EricTopol·
New ACC/AHA Guidelines published today for lipids address measuring Lp(a) and ApoB jacc.org/doi/10.1016/j.…
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Scott Isaacs
Scott Isaacs@scottisaacsmd·
Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden without sacrificing efficacy. onlinelibrary.wiley.com/doi/full/10.10…
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Daniel J Drucker
Daniel J Drucker@DanielJDrucker·
The BELIEVE study, the efficacy and safety of intravenous bimagrumab and open-label subcutaneous semaglutide, alone or in combination, in adults with #obesity nature.com/articles/s4159…
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