Sheldon Rowan

Our paper in @Nature today 🥳 We tracked 6,438 mice from puberty to death and mapped the genetics of *when* you die, not just whether a gene associates with lifespan. nature.com/articles/s4158… 59 loci. Two decades of data. Thread 👇 #Longevity #Aging #Genetics #Healthspan

What are GLP-1s actually doing? In my latest for the @nytopinion, I explore how patients experience these drugs & why the story may be more complex than many assume. nytimes.com/interactive/20… feat. insights from @DanielJDrucker @seeleyrj @BevTchangMD among many others #glp1

🦔A researcher invented a fake eye condition called bixonimania, uploaded two obviously fraudulent papers about it to an academic server, and watched major AI systems present it as real medicine within weeks. The fake papers thanked Starfleet Academy, cited funding from the Professor Sideshow Bob Foundation and the University of Fellowship of the Ring, and stated mid-paper that the entire thing was made up. Google's Gemini told users it was caused by blue light. Perplexity cited its prevalence at one in 90,000 people. ChatGPT advised users whether their symptoms matched. The fake research was then cited in a peer-reviewed journal that only retracted it after Nature contacted the publisher. My Take The researcher made the papers as obviously fake as possible on purpose. The AI systems didn't catch it. Neither did the human researchers who cited it in real journals, which means people are feeding AI-generated references into their work without reading what they're actually citing. I've covered the FDA using AI for drug review, the NYC hospital CEO ready to replace radiologists, and ChatGPT Health launching this year. All of that is happening in the same environment where a condition funded by a Simpsons character and endorsed by the crew of the Enterprise was being presented as emerging medical consensus. The people making these deployment decisions seem to believe the pipeline from research to AI to patient is more supervised than it actually is. This experiment suggests it isn't supervised much at all. Hedgie🤗 nature.com/articles/d4158…

Earthset. The Artemis II crew captured this view of an Earthset on April 6, 2026, as they flew around the Moon. The image is reminiscent of the iconic Earthrise image taken by astronaut Bill Anders 58 years earlier as the Apollo 8 crew flew around the Moon.

Will cell reprogramming with stem cell factors reverse aging? A pilot trial in eye disease will soon be the first test at the tissue level. nature.com/articles/d4158… Feature @Nature by @heidiledford @altos_labs @lifebiosciences

an exciting new #phd opportunity in collaboration with @CampagnoloLab funded by @fightforsightUK on #circadian coupling between #pericytes and #endothelial cells of the #retina findaphd.com/phds/project/r…

So the question is not only: where do resident macrophages come from? It is also: when does self-maintenance become durable, and when does it fail to do so? That is the problem Establishment Kinetics is meant to solve. Full paper in Advances in Immunology sciencedirect.com/science/chapte…

Please enjoy the latest publication from our lab "Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice"

@LammingLab Awesome study! I also really appreciate the insights this work has in sex differences!

Malia Edwards et al from Wilmer Eye Institute @HopkinsMedicine describe choroidal vascular findings in a case of multifocal geographic atrophy using histology & immunohistochemistry & correlating the findings with multimodal clinical imaging @AMD_histo_lab doi.org/10.1167/iovs.6…

We are excited to share that our team's paper is published in Immunity: "Resident tissue macrophages maintain intraocular pressure homeostasis." This work grew out of a collaboration between glaucoma clinician-scientist Katy Liu MD PhD, glaucoma physiologist W. Daniel Stamer PhD, and immunologist Daniel Saban PhD, bringing together clinical, physiological, and immunological expertise to tackle a long-standing question: does the immune system directly regulate intraocular pressure? The answer is yes. authors.elsevier.com/a/1mkeB3qNrV3V… #Glaucoma #Immunology #ResidentMacrophages #Ophthalmology #Immunity #CellPress cell.com/immunity/fullt…

"A daily multivitamin slows biological aging." That's the headline from a new Nature Medicine paper. From a randomized trial! But when you actually read the data, the vitamin is doing just about nothing. Thread.

@EricTopol If anybody is wondering about omega-3 supplements for prevention of cardiovascular disease, the NIH has an amazing summary about this. Eric is 100% correct, but something to think about for those that do not eat fish or seafood. ods.od.nih.gov/factsheets/Ome…

Q—What supplement should you take for heart health? A—None washingtonpost.com/wellness/2026/… "The American Heart Association concluded that there is not enough evidence to support the use of any supplements to prevent cardiovascular disease." “There are no adequate data that support cardiovascular benefit for supplements in healthy people who eat a healthy diet" (—me)

Hi Friends! Did you hear about STAT Madness? Not enough space to explain now😀, but check it there: statnews.com/feature/stat-m… and VOTE for DSK lab! We’re competing with a project studying how lipid supplementation may improve aging vision. Thank you for your support!!! #aging #AMD

@DrDorotaSK Dorota, you totally have my support. And that's a tough first round match against my colleague at Tufts University!

Excited to share our new manuscript from the Yoshimatsu and MacDonald labs. biorxiv.org/content/10.648…. We found that my favourite glial cells can regulate local retinoic acid signalling to specialise cone photoreceptors for high acuity vision.

New @NatureMedicine A randomized trial of antibody vs activin type II receptors with or without semaglutide (Ozempic). The antibody, bimagrumab, promotes muscle growth. Marked weight loss with the combination nature.com/articles/s4159…

@YoniFreedhoff Yes, yes. But... If you look at the fat/protein content, it should pretty effectively counteract the high glycemic index of the corn starch. If it's an improvement on the original and people were going to eat it anyway... Also has lower sodium.

Don't know if they are, but I am at least

Over a decade ago, BrightFocus Foundation grant recipient, Dr. Ilyas Washington acted on an unconventional hunch that enriched vitamin A could stop toxic buildup in the eye, a hallmark of macular degeneration. His research led to an oral pill that is now in clinical trials showing promise for slowing vision loss in rare and age-related forms of macular degeneration. Early-stage research funding is how we turn scientific hunches into breakthroughs that preserve sight. Explore the research. ↘️ brightfocus.org/news/early-res…

Below is the story of the first patient treated with a prime-edited therapeutic, developed by @PrimeMedicine in a trial led by Dr. Élie Haddad and his team at CHU Sainte-Justine. This teenager suffered from chronic granulomatous disease (CGD), an immunodeficiency, and now—10 months after treatment—the patient is healthy, stable, and living with a functioning immune system. Tracy Attebury, whose story was previously told by @ginakolata @nytimes, was the second patient treated with a prime-edited therapeutic. cihr-irsc.gc.ca/e/54638.html