@johncumbers If he’s successful, there’s zero chance it’ll cost $100.
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J.W. Simpkins
796 posts
J.W. Simpkins
@SimpkinsBooks
Writer and reader of all things fiction.
Katılım Kasım 2024
178 Takip Edilen87 Takipçiler
David Sinclair is on a mission to turn age reversal into a $100 pill.
Right now, his gene therapy costs roughly $10 million to manufacture and requires a direct injection into whichever organ you're targeting.
That's not going to work for 8 billion people.
So Sinclair's team made a breakthrough. They found that the three age-reversal genes aren't the only path to resetting cells.
They discovered CHEMICALS that do the same thing.
In mice, they can now give an animal a liquid - not genes, not injections, a drink - and rejuvenate tissues in 4 weeks.
Sinclair says it's now normal for his students to casually report: "We just rejuvenated the ear. We just rejuvenated the skin. We just cured ALS (motoneuron disease) in these animals."
He calls his lab "Willy Wonka's chocolate factory" because the discoveries blow him away every week.
But he wants one molecule that does everything. So they used AI to screen 8 BILLION candidates. They're now down to three molecules that work. And they're using AI to try to combine all three into one.
The gene therapy could cost over $100,000 per treatment. Sinclair's goal: "What if it could be $100 instead? That's what I'm working for. I want to democratize this technology so anyone even in Kenya can take these medicines."
They should know within a year or two if the molecules work in mice.
The gene therapy is the proof of concept.
The pill is the endgame.
David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging.
If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room.
Link for tickets below.
— @davidasinclair
John Cumbers@johncumbers
The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."
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@JosephKahn @AVARY Now imagine the impact AI is going to have on the film industry.
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It's underestimated how much digital cameras commodified filmmaking and collapsed the industry. With film stock, there was a barrier to entry because the technical limitation was dangerous: to store, use, and develop it took care and time. Apprenticeships in the camera department took sweat labor from the loading of mags to the threading of heavy cameras. Now it's wysiwyg monitors, lower powered lights, and more critically - infinite takes. It's easy to become a DP as the image can be checked in monitor and you don't have to wait 24 hours to see if the film comes back black...so you can gamble with newbies. The financial pressure of selectively shooting within allotted film stock is lifted. Now directors can just do piss takes forever, which accounts for the rise of improvisational acting styles.
I'm actually pro digital cameras. I shot film for years and I prefer the freedom that digital gives me. However it has obliterated foundational crew heirchies such as how the 2nd AC now just passed off cards to the DIT instead of loading mags. Filmmaking lost its magic secrecy and now everyone sees the magician's hands and sleeves. The production process is like a Burger King where everyone can see you make the burger, and the customer thinks it's easy. They just want their Whopper, no onions.
It feels less surprising when someone moves up the chain and becomes a cinematographer or director. It also feels less surprising when a director or DP quickly flames out and goes back to another day job. The hard career ladder was time, respect, camaraderie, and a sense that the person paid dues. The disadvantage was it was harder to gain those positions. The advantage was once you had them, you were more secure in them.
Experience still counts though in ways that most newer people surrounding production may not understand. Everything from resource management to effective decisions as the clock clicks on an expensive shoot day. Again I love digital cameras and I'm actually one of the first to switch over all my work to digital. It's obviously served me well. But there is a piece of me that misses the old Hollywood of filmstock, even though I fucking hated shooting it (and I'll never go back). How's that for conflicted!
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@InterstellarUAP I’ve seen plenty of stories of young people who’ve had an NDE.
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🚨 The shocking truth behind why some see the afterlife during NDEs... and others see NOTHING!
A woman who crossed over after a massive stroke explains: “Anybody like middle age or younger will see nothing because if they see anything they won’t come back again. That’s our home.”
“The second you catch a glimpse it is almost like a craving... think of the most intense craving you’ve ever had and you just want to go there.”
She says we choose human amnesia at birth so we forget the other side past age 3-5... unless your soul is old enough to remember.
This changes everything about soul ages and why we’re here.
What do YOU think happens when we die? Have you (or someone you know) ever had a near-death experience? Drop your story or thoughts below 👇
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@InterstellarUAP We break out of the "simulation" when we die.
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🚨 Roman Yampolsky: "We are DEFINITELY living in a simulation - the probability is pretty close to 100%" 😱
AI safety legend Roman Yampolskiy just broke it down: “I know never to say 100% but pretty close to that.”
He’s got the paper too “How to Hack the Simulation.” His big question: Can superintelligent agents jailbreak out of their virtual box?
Elon Musk’s one question to AGI? “What’s outside the simulation?”
What if this whole reality is just a test… and the real challenge is realizing the world isn’t real?
Have you ever felt the glitches?
Do you think we can actually escape?
What would YOU ask once you broke out?
Drop your wildest theory below 👇
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@Zedzies Is staring out a window, eating fake food, and shitting in a box really living?
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People are so confused about this tweet, so let me elaborate.
Yes, AI will eventually create art that is as good or even better than humans.
But, humans will not care for it, beside an initial curiosity, because art is not about art.
It’s about the humans who created it and their stories. Art it’s an exploration of human limits.
Humans are fundamentally not interested in what other species do, think or feel.
How many people watch AI play chess?
Matteo Pellegrini@matteopelleg
Nobody wants to read AI-generated books, watch an AI-generated movie or listen to an AI-generated song.
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@norabird “There are three rules for writing a novel. Unfortunately, no one knows what they are.”
― W. Somerset Maugham
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So many classic novels break this. There really are no rules
Joel Brigham@joelbrigham
Writers: try to avoid ANY flashbacks, info-dumps, context-building, or stage setting in at least the first chapter, but preferably the first two or three. There are good reasons for this:
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@neuralamp4ever @johncumbers They have been, and they'll keep investing more with each passing year.
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@johncumbers $100M is pocket change to $100B+ US billionaires. What's stopping them from investing in age reversal?
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A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies.
The US government BLOCKED it.
The reason? They classified the technology as too dangerous to fall into foreign hands.
Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research.
When asked if it was China, his response: "I won't say more. It's sensitive."
But here's what he DID say:
Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech.
He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change.
Sinclair believes the technology is very powerful and that society should start preparing now.
Because as he put it: "It's not an if. It's a when."
David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging.
Link for tickets below.
— @davidasinclair
John Cumbers@johncumbers
The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."
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@eVennFul_com @johncumbers I'm not afraid of dying. I am, however, afraid of getting old and decrepit.
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@johncumbers Utterly foolish and bs behavior. People are outrageous bc they are afraid of death. Take away that fear for everyone alive now and we'll all be planting rose gardens in gutted missiles.
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@thebluebonsai @joelbrigham It's when you read a newspaper while sitting on the toilet.
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Writers: try to avoid ANY flashbacks, info-dumps, context-building, or stage setting in at least the first chapter, but preferably the first two or three. There are good reasons for this:
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@bigsexyklaus @CryptoMikli What about people who've experienced an NDE?
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@CryptoMikli Bollocks. He was just high. You cannot experience reality outside of your own brain.
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Bryan Johnson explains the most unimaginable experience he felt after trying 5-MeO-DMT
“You basically experience raw consciousness and intelligence. When I say these words, multiply it by 1,000 and then move out into infinite depth, width, and dimensions. That gives you kind of a rough map of the size and space that you deal with, and it was incredibly hard because you get blasted into a space that is so foreign you don’t even know what’s happening”
“You either panic because you feel like the gates of hell are going to open and the stream of existence is going to tear you to shreds and break your brain. In that moment, you have to decide, do I try to wrestle this and wait it out until it’s over, or do you just relent and say yes. You have to be in that moment and fully say yes”
“You have to release all attachment, all preconditions, all desire. You have to release self, ego, control. You have to just relent entirely, and then it opens up this unimaginable bliss and euphoria”
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How does this bastard look better at 95 than most men do at 60?
William Shatner@WilliamShatner
At 95, I'm still smokin'! 😝 I’ve learned two things: Never waste a good cigar. Never trust anyone who says you should ‘act your age.’ 😉👍🏻
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@SophiaLiam25212 I got into writing because I can't sing or dance.
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Authors and writers!
What got you into writing in the first place?
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@AnthonyKaneEva1 @BeckyLTuch A washing machine manual?! The AI would end up writing some seriously clean prose.
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@SimpkinsBooks @BeckyLTuch I believe it trains from everything. Even your washing machine manual.
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The thing is, writers can create original work that sounds just like AI. This is a problem. If we read it, we absorb it.
I just had this experience:
A writer submitted an essay to me. I asked her if she used AI because it read like she did. She said Yes. I asked her to please rewrite the piece in her own voice. She thanked me for the encouragement, and did so.
When she came back with the revised draft, it STILL sounded like AI. I asked for another revision.
This time, she said she couldn't take it any further. It WAS her own voice, in this later draft. She didn't know how to make it sound more like herself.
I believe her. I just think her "own voice" unwittingly imitated AI in this later draft.
Point being, this is quite messy & complicated business.
Read great literature, so you absorb that, and not the slop everywhere. (Though the slop is legit hard to avoid!)
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@OldHeadHST @kc_btl84 I grew up watching the Lakers vs the Celtics and the Bulls vs the Pistons in the 80s and 90s. The NBA today pales in comparison.
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AI data centers can use up to five million gallons of water each day. Am I the only one concerned about how this could pose a serious threat to our farmers and our food supply? What happens when these centers seriously strain our aquifers and dry up irrigation systems? Is it really worth it?
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@Degen_CPA Or you could stop caring what other people think and pursue your own interests.
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If youre training to compete in powerlifting or weightlifting, you should stop immediately.
Becoming as aesthetic as you can be has much higher benefits. I competed in powerlifting mainly, with this being over 10 years.
Noone cares how much you squat, at all, theres no money in it.
If youre putting in al lthis effort, you should be training for aesthetics, being lean 12% bf, and still muscular in an aesthetic way, will have much higher benefits than you try to competition max for a "sport" no one cares about.
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About to start Blood Meridian for the first time.
Give me all your best advice.
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