Nick Hand, PhD

@karenlytle711 @McJesse ...to see the manager?

There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at @Columbia & academic career... 1/🧵

Straight up. Trump is a traitor & He is Putins Bitch. That’s it. That’s the tweet.

🟪NEW Article in press❕ Deep metabolic phenotyping of humans with protein-altering variants in TM6SF2 using a genome-first approach 🔓#OpenAccess at 👉jhep-reports.eu/article/S2589-… #LiverTwitter #MASLD #MASH

@TGTatum4_3 @LASHYBILLS 100% falls under "fighting words". Lawsuit isn't going anywhere.

@LASHYBILLS Assault and theft nice lawsuit coming his way, all because words hurt his little feelings.

Happy #FluorescentFriday! This micrograph of the mouse small intestine is a finalist in the #Proteintech microscopy image contest. Voting opens on Monday! #FluorescenceFriday #microscopy #sciart #histoart #pathart #bioart #intestine

@ElieNYC Definitely cause for thanksgiving.

Friends, I got through a 1500 word article and two interviews talking about major news involving the country of Turkey and made not one poultry related pun. Tell 16yo me that we have grown up and are officially ready to be a citizen of the world. :)

@Erik_Thomas82 @PHLEaglesNation Yeah, I thought it was just me

@PHLEaglesNation Did anyone else notice some of the Saints Players jersey numbers were a different shade of gold???

Goodnight to everyone except Khristian Boyd and Trevor Penning. 🤡🗑️

Important and be forewarned. Trump said this to crowd tonight: “Get out and vote! Just this time. You won’t have to do it anymore. Four more years. You know what? It’ll be fixed! It’ll be fine!…In four years, you don’t have to vote again.”

@BenBCDE @sirDukeDevin @MissesBun Big Star Wars fan, bad at spelling?

@sirDukeDevin @MissesBun Why Jimmy Hamel? Make it make sense please

OK this is just getting weird now 👇

@JustVent6 @RonFilipkowski He used @RocketMoneyApp to save $45 million a month?

@RonFilipkowski 🤣🤣🤣🤣 but he did, he unsubscribed

😂😂😂OMG I’M DYING!!!😂😂😂

@blekhman You seem... upset

having a hard time bringing myself to fully support kamala, mainly because of her position on venn diagrams

@NuckChorris16 @NotTonkaToy_1 Only Zuul.

@NotTonkaToy_1 There is no Brenda. 😉

Brenda younger, pudgier, and with fewer scars.

@acnewsitics She "immigrated" from San Diego, California, wherever that is.

It looks like MAGA didn't know J.D. Vance's wife was a brown immigrant and they are having a hard time accepting it.

This is the worst SNL cold open ever #Debates2024

Fun fact about the debate: It’s the first time the Secret Service has allowed a convicted felon to get this close to the President of the United States.

So it’s guy lying super loud versus guy telling the truth super soft.

@breakliquid @plasmidsaurus Next: quantum sequencing results delivered before you even start an experiment.

What just happened here, sequence results in 6hrs?! @plasmidsaurus FTW!

Exercise may be the single most potent medical intervention ever known. Its benefits in prevention outstrip any known drugs: 50% reduction in the risk of cardiovascular disease, 50% reduction in the risk of many cancers, positive effects on mental health, pulmonary health, GI health, bone health, muscle function. You name it. Exercise helps. In fact, the ability to exercise over long distances was likely key to our evolution as a species because the availability of densely caloric foods due to persistence hunting allowed our energy-avid brains to enlarge. And yet, we have had very little insight into the molecular basis of these magical effects...until now! Published in yesterday's Nature and featured on the cover was work from our consortium that represents the culmination of a couple of decades of pitching ideas to the NIH, forming a consortium, planning experiments, executing those experiments, and analyzing data at unprecedented scale, all aimed at enhancing our understanding of the molecular transducers of exercise. It was a major effort from so many in our consortium (playfully named MoTrPAC) and is the first landmark paper of many more to come. This first paper focused on the multi-tissue, multi-omics of treadmill exercise in rats. Specifically, we report the effects of eight weeks of treadmill running on the transcriptome, the epigenome, the proteome, the metabolome, the lipidome and the immunome of a broad range of tissues (in fact, 9,466 assays across 19 tissues, 25 molecular platforms, and 4 training time points). The result is the most comprehensive molecular map of exercise ever created. At Stanford, my colleague @MWheelerMD and I co-lead the bioinformatics center and it was our team's duty and privilege to ingest the data, QC the data, help analyze the data, and make the data available to the world. Various tools available at our data hub allow you to explore the data, visualize it, and download it for your own use. Have fun! And stay tuned for human data that will be coming. So many people to thank who made this possible (see the paper for details). Special shout out to the primary analysts and authors: David Amar, Nicole Gay, & Pierre Jean Baltran. Paper: nature.com/articles/s4158… Data hub: motrpac-data.org

@ElieNYC Bring me a shrubbery!

Question: If I write "strange women lying in ponds is no basis for a system of government"... does anybody under 40 know what I'm talking about? Do I have to cite it lest someone thinks I made that up myself? Should I just give up because I am old and need to be put in a home?