Sondos Zayed

SBRT (50Gy/5fx, MR adaptive) in locally recurrent PDAC. N=46 (7 w prior RT). 1 year LC 73%, median OS 19 mo. Ablative RT = feasible, safe in locally recurrent setting & can confer long term dz control. Great to see this data published - congrats @adapthyun & team! @OncoAlert

What are the outcomes associated w/ re-irradiation for meningiomas? This systematic review and meta-analysis identified 16 studies with 385 pts who received re-☢️ for meningioma. 🔘 Median time from initial RT: 38 mo 🔘 Re-☢️ techniques used: SRS (43%), FSRT (21%), particle therapy (28%) 🔘 Pooled rate of Local Control: 53% (95% CI 48-58%) 🔘 Pooled rate of Overall Survival: 73% (95% CI 67-78%) 🔘 Pooled rate of Symptomatic RT Necrosis: 8% (95% CI 5-11%) 🔘 Pooled rate of Acute Toxicity: 22% (95% CI 17-28%) 🔘 Pooled rate of Chronic Toxicity: 16% (95% CI 11-21%) 🔗 - tinyurl.com/4s2jdw2z @ASTRO_org #radonc #bcsm

Announcing Vol 1 of the #SBRT special issue! Issue online at: redjournal.org/issue/S0360-30… Podcast with host @drdavidpalma at: redjournal.org/audio-do/red-j… also Apple, Spotify, YouTube, Buzzsprout @machealthsci @FabArcidiacono8 @BCCancer @karolinskainst

Adaptive radiotherapy involves modifying treatment plans to account for changes in anatomical geometry that are not adequately mitigated with changes in alignment. Online adaptive radiotherapy capitalizes on advances in image guidance, real-time tumor tracking, and the enhanced speed of multiple steps in radiotherapy planning and delivery workflows (seen in image). Learn more in the Review Article “Effects of Radiotherapy in Normal Tissue” by @DeborahCitrin, MD, and Robert D. Timmerman, MD (@BobTimmermanMD), from the National Cancer Institute and @UTSWMedCenter: nejm.org/doi/full/10.10…

Want to try Sim-Free RT for palliative cases? Some recommendations here, led by @Melissa_O_Neil ⬇️⬇️⬇️

Here's a new RCT led by our PGY-5 resident @drviviantan, called PPI-PROTECT! 👇👇👇

@drviviantan @drdavidpalma @DrDanBreadner @goodmanC_MD Amazing work Vivian!

Excited to accrue the first patient on PPI-PROTECT 🛡️ This is a pragmatic randomized 1:1 clinical trial investigating the role of prophylactic PPI to prevent esophagitis in #lungcancer patients undergoing radiation 🫁☢️ #radonc #oncology #medtwitter

🌟🚨 CATNON final results – Practice-changing data Concurrent + adjuvant temozolomide in 1p/19q non-codeleted anaplastic glioma (EORTC 26053-22054 | The @TheLancet Oncology) 🔹 Key results ✔️ Overall survival benefit with adjuvant temozolomide ❌ No OS benefit from concurrent temozolomide alone 🧬 IDH-mutant tumors derive the greatest benefit 📊 Long-term follow-up confirms durability of effect 🔹 Why this matters • Establishes adjuvant TMZ as the critical component • Refines treatment sequencing in WHO grade 3 glioma • Supports molecular stratification (IDH status) in decision-making • Direct impact on daily neuro-oncology practice @DrNeuroOnc @RishiLullaMD @DrPrados @WellerMichael @robertjenkinsmd @DrKesari @joergchristiant @NaderSanai thelancet.com/journals/lanon…

Great presentation on advancements in RT for liver metastases. Ablative RT can be curative, non-invasive, & efficient. No better person than @MikeChuongMD to highlight the evolution & potential of innovative RT technologies in this space. #GI26

Art of Oncology The Power of “I Don’t Know” @JCO_ASCO doi.org/10.1200/JCO-25… 😄I fully agree... @myESMO

SOFT study: 141 elderly (70+), chemo-ineligible pts w locally advanced rectal cancer. Short-course RT → delayed surgery achieved 94% R0 resection & 5% local recurrence. A v reasonable, low-burden strategy for older pts w competing risks. @OncoAlert sciencedirect.com/science/articl…

Does organ preservation after cCR with TNT🧨 affect distant metasases rate in rectal ca? Results of NO-CUT🚫🔪trial @TheLancetOncol show 26% of pMMR/MSS pts achieve cCR and distant RFS 95% in nonop group vs 74% SOC @OHSUKnight @tsikitis @HKennecke sciencedirect.com/science/articl…

New today in #PracticalRO: First clinical guideline from ASTRO focusing on radiation therapy for patients with gastric (stomach) cancer. Recommendations outline radiation therapy’s role in multidisciplinary care. #RadOnc #GastricCancer #StomachCancer ow.ly/AFwV50XtM8Z

Big news: the Anatomy and Radiology Contouring Bootcamp is now FREE! 🧵🧵🧵with photos of your attendings when they were residents... arcbootcamp.com

Celiac plexus ablation⚡️! Never seen one? Check out how it's done and maybe suggest it next time for your pancreas patient with intractable pain! econtour.org/cases/172 And you know it's good cuz @NiuSanford reviewed the case! Thanks Peter Lee, MD @FoxChaseCancer for the case

Review your pancreas "Triangle Volume" with this great case, submitted by Serena Moa, MD, PhD from @JohnsHopkins w/ special shout-out to @MikeChuongMD for reviewing! PS: don't forget to check out the dose constraints for this SBRT case! econtour.org/cases/168

Thanks to @MikeChuongMD for a masterclass on ablative pancreas RT! Agree we are just seeing tip of iceberg for settings where ablative RT can improve OS or QOL in pancreas cancer. 🤞 for additional studies assessing expanding indications as summarized below. #ASTRO25

It’s out!!! 🔥🔥🔥 The PREOPANC-2 is in @TheLancetOncol Neoadjuvant FOLFIRINOX 🤜🤛 Gemcitabine based chemoradiotherapy in resecatble / BR ⚖️ No difference in overall survival 😰 Serious adverse events 40% 👍 Both regimens may be considered thelancet.com/journals/lanon…

NRG-GI011 (LAP100) has enrolled & randomized its 1st patient (U Cincinnati)🙏 355 to go. The lead enroller will get dinner on me at ASCO/GI ASCO/ASTRO 😀

Among adults with spinal cord injury, intermittent catheterization was associated with >2x the likelihood of regaining volitional bladder control within one year compared to indwelling catheterization. ja.ma/44FZYVH