Steven Truong

@Shuke_Xiao @NatMetabolism @longlabstanford @DrYongXu1

🐍Excited to share our latest work in @NatMetabolism ! The discovery of pTOS highlights the beauty of looking to nature for answers. A fantastic collaboration between @longlabstanford , @DrYongXu1 , and the Leinwand lab. Team work makes dream work!

@CellCellPress Kudos to the graphical abstract artist 👏

Now online! Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes dlvr.it/TLJNcY

Thrilled to share that my work is out in @Nature. Here, we introduce Peptide Predictor, a tool for identifying new bioactive peptides. Using this method, we discovered BRP, an anti-obesity peptide. Huge thanks to the @SvenssonLab and all our collaborators! nature.com/articles/s4158…

The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. nature.com/articles/s4158… 1/n

Nature research paper: Adipose tissue retains an epigenetic memory of obesity after weight loss go.nature.com/4eJizC8

Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature. Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇

Our latest out today @Nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…

Cool discovery about 🦇 antibodies: temperature fluctuations regulate antigen binding strength and diversity doi.org/10.1038/s41467…

Drugs like Ozempic are great for weight loss, but they make some people feel sick. We discovered that the brain circuits mediating the appetite suppression are distinct from those that mediate nausea – a finding that may be leveraged to develop more selective GLP1-based drugs.

We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today @Nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. tinyurl.com/4a6yeuke. 1/10

In @Nature today, we reported that adhesive implant-tissue interfaces can prevent the formation of observable fibrous capsules on various organs, including the abdominal wall, colon, stomach, lung and heart, in diverse animal models, including rats, mice, humanized mice and pigs. nature.com/articles/s4158…

@LindaGGriffith1 Congratulations! 🎉 You are an inspiration to us all.

Honored to be chosen for upgrading the neighborhood of endometrial organoids to include stromal cells and vasculature, in synthetic ECM, building on the 2017 papers by Turco et al and Boretto et al time.com/6967170/linda-…

@camtflower @MIT Congratulations Cam!!

🎉 Drumroll, please! Meet the 2024 #PDSoros Fellows! 🗽 Selected from 2,300+ applicants, these 30 exceptional graduate students are changing the game in their respective fields. Click the link to get to know these trailblazers! #ImmigrantExcellence 🎓🎉 pdsoros.org/meet-the-class…

Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior biorxiv.org/cgi/content/sh… #bioRxiv

#MysterySolved! Krönke &co show @Nature that glucocorticoids are anti-inflammatory not in a transcriptional manner (🤯), but by boosting the Krebs cycle in macrophages, driving excessive #itaconate that interferes with pro-inflammatory cytokine induction! Doi.org/10.1038/s41586…

Excited to share our latest work revealing the requirements of pyrimidine nucleotides in the control of glucose oxidation and lipogenesis published in @ScienceMagazine. Huge congratulations to co-first authors Umakant Sahu and @VillaElodie! science.org/doi/10.1126/sc…

I am excited to share our preprint: “A torpor-like state in mice (TLS) slows blood epigenetic aging and prolongs healthspan”. Congratulations to @LornaLJayne and big thanks to our collaborators @prof_horvath, @bloodgenes, @VadimGladyshev and others. biorxiv.org/content/10.110…

@WeiWei_Stanford @longlabstanford Congratulations, Wei! It’s been a real honor seeing you realize this story 😊

Very excited to share our recent discovery of a novel taurine metabolism pathway! We identified the orphan enzyme PTER as the predominant taurine N-acetyltransferase/hydrolase that regulates energy balance @longlabstanford biorxiv.org/content/10.110…