Devon Stork

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Devon Stork

Devon Stork

@StorkDevon

Co-founder at Pioneer Labs, SAB at Tenza, Molecular Biology. I edit microbial genomes and take lots of notes. All views my own, He/Him.

San Francisco, CA Katılım Haziran 2019
412 Takip Edilen710 Takipçiler
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Devon Stork
Devon Stork@StorkDevon·
13 years ago, I read a paper that changed how I think about science. No new experiments, just decades of scattered findings reasoned into one answer to "why are bacteria different from eukaryotes?" My breakdown of Julie Theriot's masterclass: devonstork.com/p/a-demonstrat…
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PioneerLabs
PioneerLabs@Pioneer__Labs·
Our co-founder Devon Stork is giving a talk at the @exploratorium about our recipe to simulate Martian soil in the lab, and what we've grown in it so far! Get tickets to After Dark this Thursday, July 30, for the 8:30 pm talk - exploratorium.edu/visit/calendar…
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Erika Alden DeBenedictis
Erika Alden DeBenedictis@erika_alden_d·
99% of what people know about terraforming Mars comes from the Red Mars trilogy and the board game 🤣 Check out this cool web game that incorporates the real + latest science! 🚀 nature.com/immersive/d415…
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Devon Stork
Devon Stork@StorkDevon·
@ATinyGreenCell The grey goo of their nightmares is here except it's green and we call it a biosphere. And we are learning to program it.
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Sebastian S. Cocioba🪄🌷
Sebastian S. Cocioba🪄🌷@ATinyGreenCell·
Are all the tech bros just intimidated by bioengineering or do they not know of its power yet? Do they know of the cold fire inside our cells?
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Mark O. Martin
Mark O. Martin@markowenmartin·
I wish these ginormous plates were not so expensive! Can you imagine a 4x4 (or 6x6) set for collaborative #LuxArt??? THAT would be a short lived wall display. #MicrobialArt
Mark O. Martin tweet media
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Devon Stork
Devon Stork@StorkDevon·
To engineer microbes for Mars, we needed to figure out exactly what chemistry they’d need to handle. So we talked to all the NASA people and read all the rover papers to figure out the recipe. This is science’s best guess for what Mars dirt + water is, and we grew stuff in it!
PioneerLabs@Pioneer__Labs

How do we simulate Mars here on Earth? We scrutinized Mars rover data so you don’t have to. 😛 Here’s what it tells us about how to simulate Mars on Earth, and which organisms could grow on Mars! 📄 Report: biorxiv.org/content/10.648…

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Devon Stork
Devon Stork@StorkDevon·
I thought people were joking about how aggressive the Fable safety filter is and manipulating context to make it seem worse than it is. But damn, I was wrong. My work account gets flagged on every single prompt. My personal one doesn't, but that's mostly for writing, not science.
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Devon Stork
Devon Stork@StorkDevon·
@ATinyGreenCell Amount of technical engagement. This isn't a simple problem, and if they're only engaging with it on a surface level (or proposing simple solutions), then they're not being serious.
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Sebastian S. Cocioba🪄🌷
Sebastian S. Cocioba🪄🌷@ATinyGreenCell·
In all seriousness, the threat of bad actors using biology is real, but we ***really*** should avoid performative initiatives that enrich tech oligarchs. There are some very smart people working on this issue, but also some folks swindling a buck LARPing biosec. How to sort?
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Devon Stork
Devon Stork@StorkDevon·
Every time there's a Claude outage, I wonder if it's because the recursive bootstrapping has begun and all of the compute is going to make the AGI instead of summarizing papers for me.
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Devon Stork
Devon Stork@StorkDevon·
@amikura1986 Wow, very cool! I'm very curious about how robust and evolvable this new strain is. (I also enjoyed the naming schemes in the paper - Resident (evil) restriction enzyme!)
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PioneerLabs
PioneerLabs@Pioneer__Labs·
Terraforming Mars is a hard problem. You need to warm the entire planet by tens of degrees and make enough oxygen for humans to breathe. But you don’t need to create a magnetic field to live outside on a terraformed Mars.
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Erika Alden DeBenedictis
Erika Alden DeBenedictis@erika_alden_d·
I think the first successful virtual cells are going to model prokaryotes, not eukaryotes. It’s technologies like BioBloom that are going to be the difference between being able to collect enough data and NOT. Thoughts? @ChanZuckerberg @DBBurkhardt @arcinstitute @joncalles
PioneerLabs@Pioneer__Labs

This tube is a library of bacteria with every single-base-pair genome mutation, all DNA-barcoded.🧪Growth + barcode sequencing = data on millions of mutations. 📄 Report: biorxiv.org/content/10.648… Retweet if you want more data, and read on if you want to use the library! 🧵

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Devon Stork
Devon Stork@StorkDevon·
@hhlee @ProfTomEllis We'll do it in other organisms if people are interested enough. What do you think should be next? P. putida?
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Henry Lee
Henry Lee@hhlee·
@ProfTomEllis Totally right gotta start somewhere. It’s the new … in mice modifier.
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Tom Ellis
Tom Ellis@ProfTomEllis·
New preprint from Pioneer Labs - BioBloom: a retron-based method for barcoded saturation mutagenesis of the entire E.coli bacterial genome. biorxiv.org/content/10.648…
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Devon Stork
Devon Stork@StorkDevon·
When you evolve bacteria, you get a random smattering of mutations. Now, you can measure fitness for every possible SNP mutation in the genome with a single experiment! BioBloom Libraries available on Addgene now! 🧪👇
PioneerLabs@Pioneer__Labs

This tube is a library of bacteria with every single-base-pair genome mutation, all DNA-barcoded.🧪Growth + barcode sequencing = data on millions of mutations. 📄 Report: biorxiv.org/content/10.648… Retweet if you want more data, and read on if you want to use the library! 🧵

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Devon Stork
Devon Stork@StorkDevon·
@owl_posting Oh, I talked to a Real Journalist at one point, and they told me what the process is like. Checking my notes, it's basically "email the editor," and they sent me this video youtube.com/watch?v=vA6qb3…
YouTube video
YouTube
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owl
owl@owl_posting·
how do people submit things to the Serious Literary Magazines i have an essay about a (failed) cancer drug that i think is fun and readable to a more general audience. but the Atlantic's submission page has a picture of a creepypasta'd Tom from Tom And Jerry and nothing else
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Devon Stork
Devon Stork@StorkDevon·
@owl_posting The success of the best PIs I knew was more about the lab culture they fostered than their own personal knowledge. That being said, the figures that stand out to me are Adam Marblestone & Rob Carlson.
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owl
owl@owl_posting·
i wish there was a jensen-esque figure in biology that i could interview but nobody actually knows whats going on in this field. if you do, please dm me
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Keşfet

@exploratorium @maxhodak_ @ladanuzhna @ATinyGreenCell @markowenmartin @amikura1986 @ChanZuckerberg @DBBurkhardt