Dr M V Srinivas

Vitamin C is more than just "immune support" Neurons accumulate vitamin C to approximately 10 mM intracellularly, roughly 200 times the concentration found in plasma. This gradient is maintained by SVCT2, a sodium-dependent transporter expressed almost exclusively in neurons in vivo. The brain is also the last organ to be depleted during deficiency. In guinea pigs (which, like humans, cannot synthesize vitamin C), the brain retained 24% of its vitamin C stores after 14 days of zero intake, while the adrenal glands dropped to 4% and the spleen to 3%. The body prioritizes the brain above everything else. The adrenal glands are the other major site of accumulation. Vitamin C is a required cofactor for two enzymes central to the stress response: 11β-hydroxylase, which catalyzes the final step of cortisol synthesis in the adrenal cortex, and dopamine β-hydroxylase, which converts dopamine to norepinephrine in the adrenal medulla. Padayatty et al. (2007) measured this directly in 26 human patients. After ACTH administration, adrenal vein vitamin C concentration surged from 39 to 162 μmol/L within 2 minutes, while cortisol did not peak until 15 minutes. The adrenals released vitamin C before they released cortisol. This sequence suggests ascorbate must be mobilized for steroidogenesis to proceed. This doesn't mean mega-dosing vitamin C will improve your stress response. Most of this work describes what happens during deficiency or acute demand, not supplementation above adequate intake. But it does reframe what vitamin C actually does in your body: it's not primarily an antioxidant or immune molecule. It's a required manufacturing input for cortisol and catecholamines, concentrated exactly where those hormones are made. Harrison & May, Free Radic Biol Med, 2009. Padayatty et al., Am J Clin Nutr, 2007. Bornstein et al., Endocrine Research, 2004.

@MangaloreCity Not driver fault

🚨 CCTV captures a shocking accident in Bantwal: A 48-year-old woman was hit by a car while crossing the Melkar–Mudipu highway at Dasaragudde. The impact flung her several feet. She is hospitalized in Mangalore and police have registered a case.

Today is the last day of the Income Tax Act 1961. A 65 year old law dies tonight. From tomorrow your salary slip changes. Your basic salary must be minimum 50 percent of your CTC. Companies kept it artificially low for years to reduce your PF. That ends tonight. Your PF goes up. Take home may drop slightly. Retirement corpus grows significantly. If you resign your company must settle full and final within 2 working days. Not 30 to 90 days like before. Form 16 is replaced by Form 130. Bengaluru, Hyderabad, Pune and Ahmedabad now get 50 percent HRA exemption. Same as Mumbai and Delhi. Tax slabs unchanged. Surveillance gets tighter. Tomorrow I will break down exactly what this means for your pocket. Save this. Share with every salaried man you know.

@thesneha_ Funny thing is whey protein which is from milk kept under animal sources but again milk kept under vegetarian sources. 🙏

Protein source ratings : Animal sources : • Eggs - 10/10 • Chicken breast - 9/10 • Whey Protein - 10/10 • Whole chicken - 9/10 • Goat meat - 10/10 • Liver - 9/10 • Fish - 9/10 Vegetarian sources : • Milk - 8.5/10 • Curd - 9/10 • Greek yogurt - 9/10 • Low-fat paneer - 9/10 • Soy chunks - 7.5/10 • Tofu - 8/10 • Tempeh - 8/10 • Edamame - 7/10 Vegetarian (carb heavy) : • Dal - 5/10 • Chickpeas -5/10 • Lentils - 5/10 • Green peas - 5/10

@conductr_ Gain full knowledge where u feel insecure.. Later u wil get peaks of confidence. Work honestly to gain that knowledge.

People who went from insecure to genuinely confident, what was the one shift that actually changed everything for you?

@autocarrrot Unboxing video is not proper.

Unboxing evidence shows a total security failure: Outer bag was sealed, but internal GPU box arrived with heavy physical damage. Manufacturer seals were SLICED open and taped over. Fake aftermarket barcode "X002IVLPDX" slapped on the front.

Scammed for ₹2.9L on @AmazonIN. Ordered a GIGABYTE RTX 5090 for our startup, received 1kg of Ghadi detergent. This was "Fulfilled by Amazon" (FBA), meaning it was stored and shipped directly from an Amazon warehouse. @AmazonHelp #AmazonScam #ConsumerRights [more in thread]

“The quality of the saliva, regulated mainly by the thyroid hormone, is the main factor in dental health.” — Ray Peat — Ord and Gimlette recognized tooth loss as a sign of hypothyroidism in the late nineteenth century. — Hashimoto’s patients “experienced xerostomia (chronic dry mouth), and their salivary flow rate was diminished.” — Hypothyroidism causes dry mouth and changes in the composition of oral microbiota. — Reduced saliva increases “the chance of developing dental caries, demineralization of teeth, tooth sensitivity, and/or oral infections.” — During development, hypothyroidism can cause “delayed tooth eruption, enamel hypoplasia, micrognathia, and anterior open bite.” — A 2023 paper reported “an underlying association between thyroid and salivary gland dysfunction resulting in oral dryness and high dental caries experience.” — Causality is demonstrated in a number of animal studies: “For example, desiccated thyroid (containing thyroid hormones) added to the diet of rats significantly reduces the dental caries experience while thiouracil (which lowers thyroid hormones) significantly increases their dental caries. Furthermore, when thyroid funetion was destroyed by the administration of (radioactive iodine which destroys the thyroid) a similar increase in rat dental caries was found as was noted with the administration of thiouracil... These observations lend credence to the hypothesis that the salivary glands are directly involved in the thyroid-dental caries relationship.” Ref: The effects of thyroid function on periodontal status: a systematic review and meta-analysis Xerostomia (Dry Mouth) (ADA) Evaluation of Xerostomia and salivary flow rate in Hashimoto's Thyroiditis Association between dental caries experience and salivary profile among autoimmune thyroid disease subjects - a cross-sectional comparative study Relationship of thyroid function to dental caries experience in salivary-adrenectomized rats

@shakilED @usernamee389 @DrAkhilX In the 4th slide - LT symptoms of cdi - is it hyper or hypotension?

@usernamee389 @DrAkhilX CDAD.

Classical finding on colonoscopy. Patient with pneumonia admitted to icu developed diarrhea and pain abdomen. Probable diagnosis ❓️

@lowmegatron Better take selenium directly in capsules form to avoid metals exposure in Brazil nuts.

One Brazil nut per day almost doubled thyroid hormone in hemodialysis patient. Thyroid hormone increased from from 27 to 50 ng/dL in the patients, all of whom were found to be selenium deficient. Selenium is required for the conversion of thyroid hormone, and it protects the thyroid gland. A deficiency can lead to hypothyroid symptoms, even if hypothyroidism is not diagnosed. This is because it affects thyroid hormone conversion, which is rarely tested. Selenium calms autoimmune thyroid processes, Hashimoto’s, Graves’, and thyroid eye disease, and it can accelerate the normalization of thyroid hormone levels during extreme stress. “Increasing Se levels via Brazil nut supplementation was associated with improvement in thyroid hormone levels in HD patients, although the amount of Se given was not able to restore T3 to normal levels.” Ref: Effect of selenium supplementation via Brazil nut (Bertholletia excelsa, HBK) on thyroid hormones levels in hemodialysis patients: a pilot study It’s best to check your selenium intake before supplementing using something like cronometer to make sure you aren’t already getting a lot. While many people get very little, some get a lot and an excess of selenium is also to be avoided. It's easy to do with Brazil nuts.

Important Information 🚨 If money is accidentally transferred to the wrong account while making a payment through UPI or Internet Banking, you should immediately register a complaint on the RBI toll-free number **1800-120-1740** as per RBI guidelines. This increases the chances of getting your money refunded. First, report the issue on the above number. Then visit your bank branch and submit a written complaint by filling out the required form. If the bank refuses to help or delays action, you can file a complaint against the bank at **bankingombudsman.rbi.org.in**. As per Reserve Bank of India guidelines, if an online payment is mistakenly credited to another person’s account, the bank must review the complaint and process the refund within **48 hours**. Always keep the SMS you receive after making a UPI or net banking payment. It contains the **transaction/PPBL number**, which is required while filing a complaint. In case of a wrong transaction, call the bank with all details and visit the branch within **3 days** to submit a written complaint. While filling the complaint form, make sure to include the **transaction reference number, date, amount, and the account details where the money was mistakenly sent.**

If a dog bites then next steps: Dog bite. Vaccination status unknown. Treat it as rabies exposure until proven otherwise. 1) Start with the wound. Immediately. •Wash under running water + soap for at least 15 minutes •Do not be gentle. Mechanical washing saves lives •Apply povidone-iodine or chlorhexidine after washing •Avoid tight suturing unless necessary (and preferably delayed) 2) Assess exposure (this decides urgency) Category II – scratches, minor bites without bleeding Category III – bites that break skin, bleeding, saliva on mucosa Unknown dog = assume Category III if any doubt 3) Rabies prophylaxis (do not delay) Rabies vaccine (PEP) Start immediately, day 0. Common schedule: •Day 0, 3, 7, 14 (± day 28 depending on protocol) Do not wait for symptoms. Once symptoms appear, rabies is almost always fatal. Rabies Immunoglobulin (RIG) : for Category III •Infiltrate into and around the wound •Any remaining volume IM at a distant site •Given once, on day 0 This provides immediate passive immunity while vaccine builds response. 4) Tetanus prophylaxis •Give tetanus toxoid if not up to date •Add tetanus immunoglobulin if high-risk wound and uncertain history 5) Antibiotics (dog bites are dirty wounds) Common choice: •Amoxicillin-clavulanate Covers: •Pasteurella •anaerobes •skin flora 6) Observe the dog (if possible) •If the dog remains healthy for 10 days, rabies risk is low •If the dog becomes ill or dies → continue full treatment without hesitation 7) What NOT to do •Do not ignore “small” bites •Do not rely on home remedies •Do not delay vaccine waiting for lab confirmation Bottom line In suspected rabies exposure, time = survival. Wash aggressively. Start vaccine immediately. Add immunoglobulin when indicated. Everything else is secondary

Shocking Incident!! This is a dark chocolate from NOICE. Do you notice anything unusual? Look closely... a piece of glass One of my followers @Pras_SwiftMojo ordered this dark chocolate from Instamart (Swiggy’s brand NOICE). While he was eating it, he broke a piece to give to his child. The child immediately returned it, saying something had pricked him. To his absolute shock, there was a piece of glass embedded inside the chocolate. This is extremely concerning and unacceptable; food safety should never be compromised. Shameful

Things that can safely lower thyroid antibodies: —Near infrared light, properly dosed (TPOAb ↓50%, TGAb ↓37 %) —Vitamin D (TPOAb ↓30%, TGAb by ↓25%) —Selinium (TPOAb ↓20%) —Vitamin C (TPOAb ↓20%) —Testosterone, in men with low testosterone —Levothyroxine. I am not aware of good research on T3 or NDT. For a minority: LDN, removing gluten, or removing dairy can help. Sources: Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis The effect of testosterone on thyroid autoimmunity in euthyroid men with Hashimoto's thyroiditis and low testosterone levels The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto’s Thyroiditis and Normal Vitamin D Status The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto's thyroiditis. Long-term follow-up of antithyroid peroxidase antibodies in patients with chronic autoimmune thyroiditis (Hashimoto's thyroiditis) treated with levothyroxine. One-year prophylactic treatment of euthyroid Hashimoto's thyroiditis patients with levothyroxine: is there a benefit?

Understanding Anemia Through CBC Markers Anemia is a condition where your body doesn't have enough red blood cells to carry oxygen to the tissues. There are many type of Anemia, but the most common ones (deficiency related) are 1. Iron deficiency Anemia 2. Folate/B12 deficiency Anemia ▶️ Hemoglobin: Low Hemoglobin is the hallmark of Anemia. It indicates reduced oxygen carrying capacity Men: Above 13.5 Women: Above 12.5 ▶️ Hematocrit: Hematocrit is the percentage of Red blood cells in the total blood volume. Low Hematocrit can indicate Anemia. Men: 40-50% Women: 38 -45% ▶️ RBC: Low RBC count suggests insufficient red blood cells production or excess loss. Men: Above 4.7 Women: Above 4.2 When all these parameters are on the lower side, it points towards Anemia. To differentiate between the 2 types of Nutrition deficiency based Anemia, you need to reply upon on a few other parameters in the CBC. ▶️ Means corpuscular volume (MCV): It is a parameter that determines the average size of the Red blood cells. If MCV < 80 fL, it suggests Iron deficiency Anemia (& some other conditions). It is also called Microlytic Anemia. If MCV > 100 fL, it suggests Folate/B12 deficiency Anemia (& some other conditions). It's also called Macrolytic Anemia. ▶️ MCH, MCHC: Both of these important parameters in the CBC. MCH is a measure of the average amount of Hemoglobin in each RBC. MCHC is the measure of the average concentration of Hemoglobin in given volume of RBC. When both of these parameters are on the lower side, it points towards Iron deficiency anemia & when on the higher side towards Folate/B12 deficiency anemia. Reading these Markers in conjunction with others like Iron panel, Serum B12, Serum Folate etc will give a proper picture about the nature of Anemia you are suffering from. In many cases, a person may suffer from both Iron & B12 Deficiency & you can spot patterns of both in the CBC. ⚠️ There are many conditions where your Parameters might be off. So self Diagnosis without the right knowledge might not be appropriate.

I was forced to train an intern. Spent 6 months teaching him everything I knew - every system, every client quirk, every shortcut I'd learned over five years. They made him my boss yesterday. Double my salary. Everyone in the conference room stared, waiting for a reaction. I just smiled and congratulated him. The next day, everyone froze when they opened my company-wide email. It said, "Effective immediately, I will no longer be providing training, guidance, or assistance to management. My role description does not include mentoring supervisors." HR called me into a meeting within an hour. My new boss looked panicked - he had no idea how to do half his job without me. Management tried to guilt me, saying I was being unprofessional and hurting the team. But here's the thing. I'd been doing two jobs for years. Fixing everyone's mistakes. Staying late while others went home. And for what? To watch someone I trained get the promotion I deserved? Now my boss keeps showing up at my desk with questions, and I redirect him to HR every single time. The tension is unbearable. My coworkers are divided - some think I'm brave, others say I'm being petty. ------ This is called performance punishment. You’re getting punished for being good at your job. And here is the part that makes it worse. When that promotion time comes around, they don’t promote you because you are too valuable exactly where you are. “We can’t afford to move you. You’re doing the work of three people.” So they promote the mediocre employee who has time to network and play politics because they are not buried under the workload that you created by being competent at your job. So stop being the best performer — start being strategic. Do your job well, but not exceptionally, because exceptional work gets you more work, not more money. And if they want exceptional performance, they can pay exceptional rates. Otherwise, you’re just working yourself into exhaustion while someone else gets your promotion.

@AmazonHelp @Trade_Shark Is this jus a statement or you guys really working in the background to fix the issue? More than 24hrs its gone. Very bad.

@Trade_Shark Hello! We’re sorry that some customers may be experiencing issues. We appreciate your patience as we work to resolve the issue. -Sandra

@AmazonUK getting this screen when I’m trying to order anything, no matter if I use my phone or laptop. All apps fully updated

Man to Man: ▪︎ Wake up early whether you like it or not. Sleep is a luxury you earn. ▪︎ Cut porn. It's frying your discipline and making you soft. ▪︎ Lift heavy weights 4 to 6 days a week. Track numbers. If they're not going up, you're lying. ▪︎ Eat boring food. Same meals. Protein first. Pleasure later. ▪︎ Stop explaining yourself. Explanations are for people above you. ▪︎ Learn one high-income skill and go all in. No backup plans. Backups make cowards. ▪︎ Kill useless friendships. If they don't push money, discipline or growth, they're dead weight. ▪︎ Get comfortable being alone. Loneliness is training, not a problem. ▪︎ Read contracts, finance, power, psychology. Fiction won't save you. ▪︎ Build an emergency fund. No one rescues grown men. ▪︎ Stop chasing women. Build a life that attracts them accidentally. ▪︎ Control your temper. Emotional men get manipulated. ▪︎ Dress clean and simple. No logos. No noise. Let silence flex. ▪︎ Learn to say no without guilt. ▪︎ Track your time like money. Wasted hours are stolen years. ▪︎ Fix your posture. Weak body language bleeds into weak decisions. ▪︎ Quit alcohol if you can't control it. If it controls you, it owns you. ▪︎ Learn how to fight or learn how to run fast. Ideally both. ▪︎ Pay your debts aggressively. Owing money kills respect. ▪︎ Keep your mouth shut about plans. Execute first. ▪︎ Accept that no one cares about your struggles. Act accordingly. ▪︎ Build something that pays you while you sleep. If not, you're replaceable. ▪︎ Call your parents. One day you won't be able to. ▪︎ Stop waiting for motivation. Operate on schedule. ▪︎ Become physically dangerous but mentally calm. ▪︎ Respect yourself so hard the world has no choice but to adjust. That's it. No inspiration. Just work.

I have seen intelligent people destroy their careers by never learning to play dumb. Showing your full intellect in every interaction signals a threat to those above you. They will become defiant. They will resent you. Strategic ignorance, however, lets others feel superior. They relax. They reveal information. Then you are free to act on what you learned, while they underestimate you. Ask clarifying questions you already know the answer to. Intelligence is power.

@Raghu610 Cinema etthipothala pathakam.. 😛

Nee dabba sodhi vinadaniki janalu ready ga leru gani cinema meeda concentrate chey

@HumanGopolitics @DrAkhilX 😂 😂 🤣

@DrAkhilX Really sad. Were the worms sterilised and released back on the same location or not ?

70-year-old man from China underwent cholangioscopy to investigate blockage of bile duct. During the procedure, five live Clonorchis sinensis flatworms (liver flukes) were discovered and removed from his biliary tract. NEJM-DOI: 10.1056/NEJMicm2304237