Sytse Piersma

Using an inducible genetic mouse model, researchers found that during ATP citrate lyase is required for upregulating glycolysis IL-15 priming, NK cell proliferation, cytotoxicity, and activating certain receptors. Read more: ow.ly/z3Tm50XS9Ro.

In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs

@JExpMed @sushantbangru @KalsotraLab @WUSTLmed Honored to be part of this collection!

.@SytseP @sushantbangru @KalsotraLab, Wayne Yokoyama @WUSTLmed et al show that NK cell expansion requires HuR and mediates control of solid tumors & long-term virus infection hubs.la/Q02KkRNm0 From Mechanisms & Models of #Cancer 2024: hubs.la/Q02KjVS40 #cshlcancer24

@Husultan @washupathedu @NateraGenetics @parkerici Congrats Hussein, well deserved!

I am pleased to share with you that my paper has been accepted in Nature rdcu.be/dOPyr This work would not have been possible without the guidance of an exceptional mentor, support of awesome lab members and collaborators. @washupathedu @NateraGenetics @parkerici

Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today cell.com/cell-stem-cell… extensive 15-post-🧵 below

NK cell IFNγ induces resistance of tumors to NK cells by upregulating classical & non-classical MHC-I, where therapeutic combination of monalizumab/lirilumab/DX9 may fully restore the antitumor response across NK cell subsets @capslocked_me @CerwenkaLab jitc.bmj.com/content/12/7/e…

I have waited for this moment my entire PhD for @LabWaggoner to tweet about my work!!

Expression of Ly49A alone on a H-2Dd background restored missing-self target cell rejection, NK cell licensing, and NK cell KLRG1 expression, therefore a single inhibitory Ly49 receptor is sufficient to license NK cells @SytseP #Yokoyama doi.org/10.1101/2024.0…

Cis-regulatory evolution of the recently expanded Ly49 gene family @NatureComms @twang5 @SytseP #Yokoyama @ChangxuFan nature.com/articles/s4146…

NK cells were first described five decades ago and named in 1975. This brief Perspective from Lewis Lanier @UCSF highlights a timeline of a few selected advancements in NK cell biology in each decade. hubs.la/Q02zRMB70 🎥 See video summary: hubs.la/Q02zRKh80

In the mouse, I believe the most NK cell-specific gene is Ly49h. I found its enhancer! Read about my discovery of MAP8 here: nature.com/articles/s4146… Many thanks to @twang5, @SytseP , and Wayne Yokoyama for the tremendous support!

CD8α status identifies human NK cell capacity for IL-15-induced proliferation and metabolism in a time-dependent fashion and exhibits a suppressive effect on NK cell activating receptors @jclinicalinvest @LabFehniger @CeliaCubitt jci.org/articles/view/…

Cryopreservation protocols optimized for T cells kill ~75% of NK cells w/in 24 h of thaw due to leakage of GzmB from vesicles. This is prevented by IL15/IL-18 pretreatment to ⬆️antiapoptotic genes & deplete gzmB containing granules [Berjis & Sheppard] nature.com/articles/s4146…

Trans Antigen Signaling Receptors (TASR) as a new class of NK inhibitory ligands and discovered universal capacity forCD300a to protect allogeneic T cells from NK cells biorxiv.org/content/10.110…

In this article, we provide a brief perspective of the promise of allogeneic cell therapies against cancer. We consider rejection by the recipient as a central pitfall and discuss approaches to reduce this rejection by genetic engineering nature.com/articles/s4157…

@LabWaggoner Thank you for sharing!

Tissue-specific features of ILCs in antiviral defense REVIEW by @SytseP nature.com/articles/s4142…

Online now in Cellular and Molecular Immunology: my review on the role of ILCs in virus infection with a focus on tissue specific features. nature.com/articles/s4142…

ITAM-based receptors in NK cells @oaaguilar503 doi.org/10.1111/imr.13…