Gene Lay Institute of Immunology & Inflammation

The Gene Lay Institute of Immunology and Inflammation was founded on a generous gift @BrighamWomens @MassGeneralNews & @harvardmed. give.brighamandwomens.org/gene-lay-insti…

New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment. nature.com/articles/s4146… @broadinstitute @MGHMolBio @MGBResearchNews

Jon Zurawski & Rob Bakshi had oral talk at ACTRIMS in San Diego integrating 7T LME and cortical lesions with novel CSF proteomic signatures in MS. Here’s link to Jon's talk: tinyurl.com/bmj44587. We also presented data on proteomic signatures in CSF linked to nasal foralumab.

1/2 New paper out now in Cell Systems @CellPressNews describing development of a deep learning framework to predict allergenic microbial proteases! sciencedirect.com/science/articl… @broadinstitute @MGHMolBio @MGBResearchNews

Was in Saudi Arabia in Dec with Saef Izzy & set up joint projects between the Ann Romney Center & KAIMRC. Projects include nasal anti-CD3 for MS, type 1 diabetes & heat stroke plus probiotics for MS. Here’s link to slides Saef showed in Feb in Riyadh; tinyurl.com/ynu23sfy

Published new concept of “Progression Independent of the Triggering Event” in Neurology Neuroimmunology & Neuroinflammation - shorturl.at/x4u5g. Was on cover. Multiple conditions cause CNS damage and trigger common mechanisms that identify common therapeutic approaches.

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases cell.com/cell-genomics/… @CellGenomics @TheXavierLab @broadinstitute

Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis! cell.com/cell-genomics/… #fibrosis #lung #ILD

If you haven’t registered yet, now's the time! Some of the best minds in neuroimmunology, neuroscience, immunology + AI — in one room. RTN2026 | Oct 26–28, 2026 | Weizmann Institute conferences.weizmann.ac.il/RTN2026/ @jonykipnis @QuintanaLabHMS @stevens1lab @RejaneRua @WeizmannScience

TFR cells are a dynamic and plastic cell subset, the differentiation of which is controlled by intrinsic and extrinsic programs that work together to form a feedback loop to control humoral immunity @NatImmunol @TheSageLab @BrighamWomens nature.com/articles/s4159…

New work, now online in @CellCellPress! Using a phased, binder-first strategy, we identified a ligandable pocket on CARD9 and discovered a small-molecule inhibitor of CARD9 inflammatory signaling. (1/7) sciencedirect.com/science/articl…

Online now: Immune-brain plasticity underpins stress and affective behaviors dlvr.it/TPycyb

By reprogramming the tumor microenvironment with an engineered virus, @QuintanaLabHMS boost anti-tumor immunity in a glioblastoma model @NatureCancer. @MGBResearchNews @broadinstitute @harvardmed massgeneralbrigham.org/en/about/newsr…

🌟 Check out new content @NatureCancer by Francisco Quintana and collaborators 👇 doi.org/10.1038/s43018…

🔔 New episode alert! Dr. Ana Anderson (@AnaAndersonlab) from @HarvardMed talks about her work on #ImmuneRegulation in cancer. ▶️ bit.ly/3KzeIOO

Excited to share our review in @NatRevRheumatol is now online where we discuss PD-1, BTLA and TIGIT as promising agonist targets for rheumatic disease. Congrats to Naomi Goldman and Arlene Sharpe for a true team effort! #immunotherapy #autoimmunedisease #rheumatology

Immune dysfunction in Alzheimer disease — a Review by Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay K. Kuchroo, Rudolph E. Tanzi & Howard L. Weiner @OlegButovsky @mejorfi @KuchrooLab @RudyTanzi @weinerlabhms nature.com/articles/s4158…

Thrilled to share our invited Nature Reviews Neuroscience review on the role of peripheral immunity in Alzheimer’s disease. Honored to write this piece with outstanding colleagues @KuchrooLab, @RudyTanzi, @weinerlabhms, Mehdi Jorfi and rising stars from my lab Neta Rosenzweig and Kilian Kleemann. My sincere thanks to Editor Katherine Whalley for the invitation. The time has come to deeply investigate peripheral immunity in AD.

Review @NatRevNeurosci @OlegButovsky Immune dysfunction in Alzheimer disease nature.com/articles/s4158…

Join us next week for an episode with Dr. @AnaAndersonLab from @HarvardMed! Her research focuses on understanding the pathways and mechanisms that regulate the #AntiTumor immune response.

🚨 Join the Butovsky Lab @HarvardMed, @BrighamWomens ! butovskylab.bwh.harvard.edu 📍Boston, MA | 🧪 NIH-funded | 🌎 Collaborative & translational environment 👉 Apply with CV + cover letter + references to obutovsky@bwh.harvard.edu 📅 Start date: Sept 2026 or earlier