Gene Lay Institute of Immunology & Inflammation

The Gene Lay Institute of Immunology and Inflammation was founded on a generous gift @BrighamWomens @MassGeneralNews & @harvardmed. give.brighamandwomens.org/gene-lay-insti…

The Hemberg Lab is looking sharp in their new Gene Lay Institute jackets! 🔬 Proud to see our researchers repping the Institute while driving discoveries in immunology and inflammation. #GeneLayInstitute #Research #Immunology

🎉 Celebrating 3 Years of Impact! 🎉 On June 26, The Gene Lay Institute proudly celebrated its 3rd anniversary alongside our valued members. This milestone reflects the dedication, collaboration, and shared vision of everyone who has been part of our journey. #GeneLayInstitute

Congratulations to the Anderson and Kuchroo Labs on two back-to-back papers advancing our understanding of Th17 biology and autoimmune disease. Proud of our investigators and trainees driving immunology forward. Read more: cell.com/immunity/fullt… cell.com/immunity/fullt…

What an incredible day at the @GeneLayInst 's inaugural retreat on April 27, 2026! 🎉 Watch the retreat highlights below! 🎥⬇️ #GeneLayInstitute #Immunology #Research #LifeSciences #TeamScience #ScientificCollaboration

Join us and @GeneLayInst on July 31st for the Annual Symposium! This year's speakers include Marco Colonna, Shimon Sakaguchi, @stefanispranger, and @victora_lab. Register using the QR code in the flyer! #inflammation #immunity #disease #genelayinstitute

Phase 1 trial of nasal Protollin (TLR adjuvant) in AD published in Nature Aging. tinyurl.com/4f2r9tec Enhances monocyte Aβ phagocytosis/dampens CD8+T cells. No toxicity. Clears brain Aβ in animals. Now AD phase 2 trial. Long road to translate-1st published in 2008. Never quit.

My book THE BRAIN UNDER SIEGE translated to Chinese by Mao Ying, Dean of Huashan Hospital Fudan Univ: tinyurl.com/64ydhdc2. On the cover: “How to tame an invisible killer more cruel than cancer” and “Achievements of 30 years hard work.” Very gratifying. Disease is universal.

Online now: A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state dlvr.it/TT1F78

Online now: Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity dlvr.it/TT1JQ4

These findings could help address steroid resistance of Th17 cells frequently seen in the clinic & constrains the efficacy of this mainstay of treatment for autoimmune flares. @GeneLayInst @MGBResearchNews @HarvardMed @BroadInstitute @WeizmannScience 3/3

2⃣IL-23 switches on a pro-inflammatory Th17 state by stabilizing RoRgt & impairing GC sensing, via epigenetic & transcriptional regulation. @AnaAndersonLab @YosefLab. 2/3 cell.com/immunity/fullt…

💫Back2back papers in @ImmunityCP led by #DandanYang: multi-omics studies reveal how the gluococorticoid (GC) pathway restrains Th17 cell pathogenicity. GC steroid synthesis & sensing maintain the homeostatic state of Th17 cells. @AnaAndersonLab 1/3 🧵 cell.com/immunity/fullt…

IL-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity @ImmunityCP @KuchrooLab @nir_yosef1 @WeizmannScience @harvardmed cell.com/immunity/fullt…

Yesterday, the inaugural Gene Lay Institute (GLI) retreat was held at Harvard Business School. It was a pleasure to join the gathering of all GLI scientists. @GeneLayInst

A new Science #Immunology study addresses recent, conflicting findings on the role of #IL17 in #MultipleSclerosis, showing that IL-17A and IL-17 drive disease in EAE mouse model. @KuchrooLab scim.ag/3OtoiF7

An adaptive source of IL-17A/F is indispensable for EAE development! And B cell-derived IL-17 induces IL-23 signaling required to convert stem-like Th17 cells to encephalitogenic Th17 cells. @GeneLayInst @MGBResearchNews @HarvardMed @BroadInstitute science.org/doi/10.1126/sc…

Review @NatImmunol @QuintanaLabHMS Astrocyte-driven immunosuppression in the brain tumor microenvironment nature.com/articles/s4159…

B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis @SciImmunology science.org/doi/10.1126/sc… @KuchrooLab @BrighamWomens

Review @JExpMed @Vignali_Lab @aamirbkbz @KuchrooLab Inhibitory receptor agonists: Emerging strategies in immune modulation rupress.org/jem/article-ab…

Tim-3 restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway @NatureComms @KECKSchool_USC nature.com/articles/s4146…