Tilmann Schober

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Tilmann Schober

Tilmann Schober

@TilmannSchober

Pediatrician & Infectious diseases specialist, Husband & Father, Hiker & Cyclist, Reader & Gardener

Munich, Germany Katılım Mart 2020
153 Takip Edilen442 Takipçiler
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Tilmann Schober
Tilmann Schober@TilmannSchober·
What are the actual benefits of testing for respiratory viruses in the ED? Does testing change patient management? Does it reduce antibiotic use? Our systematic review and meta-analysis – just published in @JAMAInternalMed jamanetwork.com/journals/jamai… 🧵1/13
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Brad Spellberg
Brad Spellberg@BradSpellberg·
I can’t believe no one’s made a gif of this one yet. I’ll quote the great 20th century philosopher, Dirty Harry. “Excuses are a lot like assholes. Everybody has one.”
Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟@ABsteward

@DiorIzzy @BradSpellberg @DrToddLee Well They will always find an excuse You know the exclusion criteria Eg: atients with severe immunosuppression, foci requiring prolonged treatment, single cultures with possible contaminants, or cultures yielding Staphylococcus aureus #idxposts

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Tilmann Schober
Tilmann Schober@TilmannSchober·
Hello everyone! Dear #IDtwitter! I also have an account on the other side 💙, please follow me there if you want to keep in touch: @TilmannSchober.bsky.social. I will stay here for a while, but will not not be as active
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Tilmann Schober
Tilmann Schober@TilmannSchober·
Clinical research as it is supposed to be 👇
Todd C. Lee@DrToddLee

Speaking of S. aureus! @snap_trial passed 3500! Writing papers: cefazolin (MSSA) and penicillin (PSSA) vs (flu)clox Recruiting: Adj clinda vs not (all) Adj cefazolin vs not (MRSA) Oral switch vs IV (all) cefazolin +/- Erta/Placebo (MSSA) Dapto vs Vanco (MRSA, starts tomorrow!)

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Brad Spellberg
Brad Spellberg@BradSpellberg·
Hey @DrToddLee, do you like this one? See highlighted mortality result. Compare to conclusion: "Rezafungin was well tolerated and efficacious..." Do people not peer review things anymore?
Brad Spellberg tweet media
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Our World in Data
Our World in Data@OurWorldInData·
HPV vaccines offer a rare opportunity to effectively eliminate cervical cancer. By taking this opportunity, it’s possible to save the lives of hundreds of thousands of women each year.
Our World in Data tweet media
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Tilmann Schober
Tilmann Schober@TilmannSchober·
Comprehensive study on unconditional cash transfers. TLDR: "Overall, the negative effects on labor supply do not appear to be offset by other productive activities" More in the well-written🧵👇
Eva Vivalt@evavivalt

We are happy to release the first results of a RCT of a US program that provided $1,000/month unconditionally for 3 years to 1,000 individuals in the treatment group, with a group of 2,000 people receiving $50/month serving as the control. These are sizable transfers. 1/ 🧵

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Michael Calderwood, MD, MPH
Michael Calderwood, MD, MPH@CalderwoodMD·
More is not always better. Adding vancomycin to cefazolin as surgical prophylaxis in patients undergoing arthroplasty does not improve outcomes in patients not known to be MRSA colonized. Outcomes WORSE for knee arthroplasty. Just don't. nejm.org/doi/10.1056/NE… #IDWeek2024
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Tilmann Schober
Tilmann Schober@TilmannSchober·
@apsmunro You have seem to have an extremely nerdy social media bubble 🤓 I think I have committed all these sins at some point during my career...
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Alasdair Munro
Alasdair Munro@apsmunro·
A list of statistical sins in order of severity, according to social media: - Doing analysis in Excel - Doing analysis in SPSS - Not doing analysis in R - Testing for normality - Not testing for normality - Being a frequentist - Mentioning p values - DAGless regression
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IDWeek
IDWeek@IDWeekmtg·
A seven-day course of antibiotics for hospitalized patients with bloodstream infections is just as effective as a 14-day course, according to new findings presented at #IDWeek2024. Learn more: idsociety.org/news--publicat…
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Tilmann Schober
Tilmann Schober@TilmannSchober·
I ❤️ it, we need more of this stuff: pragmatic, open-label RCTs with meaningful primary outcomes. 🇩🇰 leads the way...
Tor Biering-Sørensen, MD, MSc, MPH, PhD@TorBiering

DANFLU-2 update 🚨 We have today, after 3 weeks of recruitment for this flu season, randomized >116000 Danish citizens. We are getting very close to the total number of 340000 randomized over 3 seasons of recruitment. Very proud of my @CTCPR_ team! 👏🙌👍 @SSI_dk @BiomedUCPH

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Tilmann Schober
Tilmann Schober@TilmannSchober·
🔥New antiviral (Ziresovir) in hospitalized infants with RSV Infection. nejm.org/doi/full/10.10… -0,8pts in the 12pt Wang bronchiolitis score at day 3. I am not impressed. In fact, most antivirals for acute infections suck. Let's rather invest in vaccines! 💉
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Casanova Lab
Casanova Lab@casanova_lab·
1/ We are excited to share our report in #JEM that about 10% of severe tick-borne encephalitis (TBE) cases, triggered by the TBE virus (TBEV), are due to pre-existing auto-Abs neutralizing type I IFNs (doi.org/10.1084/jem.20…).
Casanova Lab tweet media
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Petter Brodin
Petter Brodin@BrodinPetter·
Passive immunity from mother to offspring is important for protecting against infections early in life but can also hamper immune responses to vaccines in newborns. This is why some vaccines are not given as early after birth as we'd like (ex measles). New interesting work from @katha_lahl lab & @TheYuanLab show that de novo immune responses are in fact delayed, but not blunted by maternal abs with B cell responses traced back to original infection by lineage tracing. Nice work! biorxiv.org/content/10.110…
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John Mandrola, MD
John Mandrola, MD@drjohnm·
The sky is blue and yet another cooling RCT is negative 👇🏻 But. It doesn’t matter, people will still do it. I’m not sure there is an intervention more resistant to negative trials.
𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊@PulmCrit

preventative Arctic sun in ICU pts with stroke: -less fever -more shivering -no improvement in outcome I think we under-estimate how uncomfortable external cooling is. Imagine that your body wants to spike a fever (so you feel cold), but you're trapped in a 5C water bath🥶 #1/2

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Tilmann Schober
Tilmann Schober@TilmannSchober·
@FReichert667 I think maternal vaccination + mRNA vaccine at 6 month would have been a great combination...
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Dr. F. Reichert
Dr. F. Reichert@FReichert667·
@TilmannSchober However -will it still be needed after nirsevimab and the possibility of maternal vaccination?
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Keşfet

@BradSpellberg @DrToddLee @apsmunro @holz_hannes @katha_lahl @TheYuanLab @elonmusk @BarackObama