Tirosh Lab

Registration for the Gordon Research Conference (GRC) in Single-cell cancer biology is now open! It will take place March 22-27, 2026, in Ventura, CA. For more info and registration: grc.org/single-cell-ca…

Congrats Alissa!! Highly recommended for students

👉The Curated Cancer Atlas. Impressive: “124 scRNA seq datasets for >40 cancer types, with improved data annotations, visualizations and exploration”. From Michael Tyler and @TiroshLab @WeizmannScience nature.com/articles/s4301…

Important publicly available resource from @TiroshLab @WeizmannScience in @NatureCancer The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution nature.com/articles/s4301… 124 single cell datasets across 40 cancers, >2800 samples.

1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @M_Nomura, Kevin C. Johnson and Luciano Garofano, which was published @NatureGenet! nature.com/articles/s4158…

1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! nature.com/articles/s4158… , nature.com/articles/s4158…

Now online in @CD_AACR: #Glioblastoma-Cortical #Organoids Recapitulate Cell State Heterogeneity and Intercellular Transfer - by Vamsi Mangena, @RChanoch, Paola Arlotta, @tiroshlab, @MarioSuva, & colleagues doi.org/10.1158/2159-8… @broadinstitute @weizmannscience @MGHCancerCenter

A wonderful collaboration with @MarioSuva lab, @MarianNeidert, co-led by @alissacg, @GaliliNoam and @RouvenHoefflin, with thanks to all authors for their contributions! #spatialbiology #GBM #Visium #CODEX #PhenocyclerFusion #hypoxia 13/end

The layers model is consistent with histology and IVY-GAP annotations but provides further granularity, dissecting the cell state and cell type composition of classical features and exposing the long-distance effects of hypoxia. 12/

Excited to share our new paper in @CellCellPress on spatial organization in glioblastoma authors.elsevier.com/c/1izT9L7PXqQI9. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal five-layer organization of cellular states and a role of hypoxia as tissue organizer. 1/