Tyler Heiss

I'm thrilled to share that I've been awarded an NIH NRSA F32 fellowship through the NCI to support my postdoctoral studies at Rockefeller! Beyond thankful, and looking forward to tackling unsolved problems at the interface of chemical and cancer biology over the next three years

Super excited to see my most recent work (and first paper!) from the @KapoorLab_RU online @J_A_C_S! By taking advantage of electrophilic 'scout fragments', we identify allosteric inhibitors of helicases, enzymes that have been challenging to target. pubs.acs.org/doi/epdf/10.10…

Our latest review, written by graduate student Natalie Jones, is online! Click below to learn how genetic approaches can help us more effectively use chemical probes and test therapeutic hypotheses: authors.elsevier.com/a/1hIt7,LqArQC…

We have an open position for a Postdoctoral researcher in Chemical Biology with Synthetic Chemistry experience! If you are interested in chemical biology, proteomics, and protein degradation, please reach out to me (vinograd(at)rockefeller.edu)! jobrxiv.org/job/the-rockef…

Red-Shifted Coumarin Luciferins for Improved Bioluminescence Imaging @UCIrvine @UCIChemistry @theNCI @ASUBiodesign @ASU_SMS #Redshifted #Coumarin #Luciferins #Bioluminescence #Imaging pubs.acs.org/doi/10.1021/ja…

@SouthwestAir Our flight from IAD —> ATL for 12/27 was just cancelled. Any update for folks on this flight?

We continue to experience high call and social inquiry volumes. Please check your flight status and explore self-service options here: swa.is/Dec2022

I am thrilled to receive the NIH Director's New Innovator Award for a conceptually novel method called GO3D single-cell spatial multiomics. My lab is hiring postdocs and students in this direction. Please email me if you are interested or have great candidates to recommend 🏆!

Excited to share that I will be joining the Department of Biochemistry and Molecular Biology in the Rutgers Robert Wood Johnson Medical School this October! My lab will focus on single-molecule approaches to understanding the dynamics of ribosome biogenesis in health and disease.

doi.org/10.7554/eLife.… @eLife Please check out our paper on the AAA ATPase Mdn1! Mdn1 drives ribosome biogenesis by extracting ubiquitin-like domain proteins from 60S precursors. Have a read to see how intramolecular tension and catch bonds play into this essential process!

@XiaoyuShi2 @UCIBioSci @UCIrvine Congrats, Xiaoyu! Well deserved!

Delighted to share that I've been selected for an endowed research fellowship from the Hellman Foundation! This brings pilot funding for an exciting new direction "regulatory mechanisms of ageing and cancer". @UCIBioSci @UCIrvine news.uci.edu/2022/07/08/sev…

@_carlabeth @jenn_prescher Wonderful! Congrats, Dr. Brennan!

@BeattyLab @J_A_C_S Love this suggestion, Prof. Beatty! The produced fluorophores are readily translatable to 2-photon imaging, and we leverage this capability in the manuscript. Completely agree there's more expts. to be done here!

Thrilled to see this story finally out today in @J_A_C_S. Here, we pioneer a first-in class fluorescence "turn-on" reaction of cyclopropenones and phosphines for multicomponent, real-time imaging in live mammalian cells. (1/4) tinyurl.com/Heiss-JACS-2022

@mrityug @J_A_C_S Thanks, Jay! Good luck w/ finishing up at UCI. I'll keep an eye out for Spitale lab manuscripts from you!

@BrianDNA @J_A_C_S Thank you for the feedback, Brian! Hope all is well at UCI!

@TylerKHeiss1 @J_A_C_S Beautiful chemistry, Tyler! Congrats!

@LabRullo @J_A_C_S Thank you, Anthony!

@TylerKHeiss1 @J_A_C_S Now this is clever !

#ASAP #JACS #J_A_C_S #ACS #chemicalbiology #bioorthogonal #bioorthogonalchemistry #AcademicChatter #AcademicTwitter #BiologicalChemistry #Bioorganicchemistry #fluorogenic #fluorescence #fluorophore #Science #lipidtime

Because of the high fluorescent enhancement, biocompatibility, and multicomponent imaging capabilities, we anticipate that fluorogenic cyclopropenones should enable a broad range of biological pursuits. Congrats and many thanks to my advisor at @UCIChemistry, @jenn_prescher!