Valerio Gristina

791 posts

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Valerio Gristina

Valerio Gristina

@VGristina

Medical Oncologist, PhD. Clinical Research Fellow@University of Palermo. Lung Cancer. Liquid Biopsy and Translational Research aficionado.

Katılım Mayıs 2019
333 Takip Edilen427 Takipçiler
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Roberto Borea, MD
Roberto Borea, MD@RobertoBoreaMD·
⌛️ Such a timely and important paper from the @isliquidbiopsy 🩸#LiquidBiopsy is evolving dramatically fast, and terminology must be updated with the advancements! @UmbertoMalapel1 @ChristianRolfo @drgandara @MJOSESERRANO19 @LuisRaezMD @ReduzziCarol @DrYukselUrun @nicolafusco
ELO@ElJanLe

✨ Excited to share our latest publication in Journal of Liquid Biopsy Harmonizing Definitions in Liquid Biopsy: A Terminology Framework by ISLB doi.org/10.1016/j.jlb.… A key step forward to bring clarity and consistency to a rapidly evolving field 🙏 Grateful to all co-authors

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Roberto Ferrara
Roberto Ferrara@RobertoFerrara_·
Depleting intratumoral Tregs by ADCC with the FC active CTLA-4 inhibitor, gotistobart, potentially interesting but not preventing hyper progressions and crossing of survival curves. #ELCC2026
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Alessio Cortellini
Alessio Cortellini@ACortelliniMD·
Great to see eventually these initial (strong) signals of benefit for gotistobar vs docetaxel in 2nd L SqNSCLC just presented at #ELCC26 A space where we're clearly struggling to raise the bar! Any other CTLA4i believer out there? @IASLC @myESMO
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NEJM
NEJM@NEJM·
RECITE: In a phase 3 trial in patients with persistent chemotherapy-induced thrombocytopenia, 84% of those receiving romiplostim had no chemotherapy dose modifications, as compared with 36% of those receiving placebo (odds ratio, 10.16). Full trial results: nejm.org/doi/full/10.10… Editorial: Thrombopoietin-Receptor Agonists in Chemotherapy-Induced Thrombocytopenia nejm.org/doi/full/10.10…
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Alessandro Russo
Alessandro Russo@Al3ssandroRusso·
Congrats to my friend @UmbertoMalapel1 and all the editorial team! @isliquidbiopsy @ChristianRolfo
International Society of Liquid Biopsy@isliquidbiopsy

📈 A promising milestone for the Journal of Liquid Biopsy (JLB) The Journal of Liquid Biopsy @jlb_islb (Open Access; Elsevier; E-ISSN: 2950-1954) is currently is on track to receive its first official CiteScore. Based on the current CiteScoreTracker 2025, the journal is trending around ~3.6—a very encouraging signal and a great achievement for a young, focused journal in liquid biopsy and precision oncology. A sincere thank you to our authors, reviewers, editors, and the entire ISLB community for helping build this momentum. @UmbertoMalapel1 @ElJanLe @drgandara @MJOSESERRANO19 @ChristianRolfo @DrYukselUrun @ErulEnes @ReduzziCarol @RobertoBoreaMD @jlb_islb @ddemiguelperez @PasqualePisapia @Al3ssandroRusso @eleonora_nicolo @DrMirallas #ISLB #JournalOfLiquidBiopsy #LiquidBiopsy #OpenAccess #Scopus #CiteScore #PrecisionOncology #ctDNA #CTC

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David Gandara
David Gandara@drgandara·
Results of OSI plus DATODXD after PD on OSI are worth pursuing. Nice results although a small study. Needs confirmation.
Aya Mohamed | MSc, MD 🎗@Dr_Oncologista

ORCHARD (Phase II): 🫁 Osimertinib + Dato-DXd demonstrated clinically meaningful activity in EGFR-mutated advanced NSCLC post–1L osimertinib. ORR: 43% (4 mg/kg) vs 36% (6 mg/kg) mPFS: 9.5 vs 11.7 mo mOS: 19.8 vs 26.2 mo (immature) annalsofoncology.org/article/S0923-… @OncoAlert #lcsm

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Alessio Cortellini
Alessio Cortellini@ACortelliniMD·
A topic close to my heart for years... family history in #NSCLC is often underestimated and diffucult to ascertain given the role of other stronger risk factors (smoking/environmental) In FAHIC-Lung, our team at @CampusBioMedico and @PoliclinCampus developed a structured, weighted family history score identifying patients with enriched familial cancer risk, to support targeted referral to genetic counseling & germline testing. Grateful to @FCitarellaMD for leading the effot and to all collaborators for the team effort @RobertoFerrara_ @MassimoDiMaio75 @PCascetta @IASLC sciencedirect.com/science/articl…
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Chul Kim
Chul Kim@chulkimMD·
We continue to uncover rare drivers in NSCLC. An insightful talk by Dr. Politi - RASGRF1 fusion: increase GTP-RAS signaling; sensitive to MEK inhibition in preclinical models. - CLIP1-LTK: 80% homology to ALK; response reported with lorlatinib (case report) #TTLC26
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International Society of Liquid Biopsy
International Society of Liquid Biopsy@isliquidbiopsy·
🇪🇸 ISLB leadership at the XI Liquid Biopsy Symposium (Jan 22–24, 2026 | Santiago de Compostela, Spain) 🎙️ @ChristianRolfo — ISLB Past President & CSO: “Circulating biomarkers for immunotherapy outcomes” (Fri, Jan 23 | 15:15–15:30) 🎙️ @UmbertoMalapel1 — ISLB President: “ESR1 mutation detection at resistance… the role of liquid biopsy” (Thu, Jan 22 | 16:50–17:10) 🗣️ @ElJanLe — ISLB Vice President: Panelist, “What do we expect from the future?” (Sat, Jan 24 | 12:30–13:30) Read more: tacticsmd.net/congreso/liqui… @UmbertoMalapel1 @ElJanLe @drgandara @MJOSESERRANO19 @ChristianRolfo @DrYukselUrun @ErulEnes @ReduzziCarol @RobertoBoreaMD @ddemiguelperez @PasqualePisapia @Al3ssandroRusso @eleonora_nicolo #LiquidBiopsy #ctDNA #CTCs #cfDNA #PrecisionOncology #ISLB
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Xiuning Le MD PhD
Xiuning Le MD PhD@LeXiuning·
📖 New online from our group at @MDAndersonNews Mechanisms of Resistance to Trastuzumab-DXd in #LungCancer 🔬✨ Key findings: 👉 Payload resistance driven by #SLFN11 loss and copy-number gains in the efflux pump ABCC1/MRP1 👉 Secondary #HER2 extracellular domain mutations at the antibody binding site (e.g., D582, F595) 👉 Tumors with acquired payload resistance or domain IV mutations retain HER2 signaling and remain sensitive to TKIs, including #zongertinib and #sevabertinib 💡 🎊 🔥 This is the first comprehensive preclinical and clinical investigation of #ADC #MoR in lung cancer, with direct therapeutic implications. jto.org/article/S1556-…
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Stephen V Liu, MD
Stephen V Liu, MD@StephenVLiu·
Update on CheckMate 77T (addition of perioperative nivolumab to neoadjuvant chemo in resectable NSCLC) @NatureCancer. In stage III N2+ NSCLC: EFS HR 0.46, 1y EFS 70% vs 45%, pCR 22% vs 5.6% - in multistation N2, EFS 0.43! Profound benefit here. nature.com/articles/s4301…
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Annals of Oncology
Annals of Oncology@Annals_Oncology·
🆕Article in press: Germline alterations in patients with #LungCancer 👉#fig1" target="_blank" rel="nofollow noopener">annalsofoncology.org/article/S0923-…
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International Society of Liquid Biopsy
International Society of Liquid Biopsy@isliquidbiopsy·
📌 SAVE THE DATE – 22–23 May 2026 We are excited to announce the upcoming International Society of Liquid Biopsy (ISLB) Workshop, entitled: “The Path to Leading Innovation in Liquid Biopsy” 📍 HABITA79 MGallery Pompeii – Pompei (NA), Italy 🗓 22–23 May 2026 👥 Chairs: @UmbertoMalapel1 & @ChristianRolfo A unique opportunity to explore cutting-edge advances in liquid biopsy, exchange views with international experts, and help shape the future of cancer diagnostics. 👉 More details on the program and registration will follow soon – stay tuned! @UmbertoMalapel1 @ElJanLe @drgandara @MJOSESERRANO19 @ChristianRolfo @DrYukselUrun @ErulEnes @ReduzziCarol @RobertoBoreaMD @jlb_islb @ddemiguelperez @PasqualePisapia @Al3ssandroRusso @eleonora_nicolo #ISLB #LiquidBiopsy #PrecisionOncology #Pompei2026
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Valerio Gristina
Valerio Gristina@VGristina·
Inspiring session with @Al3ssandroRusso brilliantly presenting old and new insights on ALK- and ROS1-positive #NSCLC being at the IV FONICAP–LILT National Congress @MinisteroSalute. 📊 Advancing clinical trials evidence meaningfully supports patient care. 🔬 #LCSM
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@isliquidbiopsy @UmbertoMalapel1 @ChristianRolfo @drgandara @MJOSESERRANO19 @LuisRaezMD @ReduzziCarol @DrYukselUrun