Scientists at Stanford Medicine have proposed an explanation for the rare cases of myocarditis that can occur after mRNA COVID-19 vaccination. The research points to a two-step inflammatory process involving the cytokines CXCL10 and IFN-gamma.
According to the study, vaccine-activated immune cells, particularly macrophages, produce high levels of CXCL10. This molecule then stimulates T cells to release IFN-gamma, creating a potent inflammatory signal that can damage heart muscle cells. The team confirmed this pathway through experiments using human heart tissue models, immune cells, and mice.
Importantly, blocking CXCL10 and IFN-gamma reduced signs of heart injury in laboratory models while largely preserving the protective immune response generated by the vaccine. The researchers also tested genistein, a natural compound found in soybeans, which showed anti-inflammatory effects in the models, though further clinical studies are required.
Myocarditis following mRNA vaccination is very rare, occurring in approximately 1 in 140,000 people after the first dose and 1 in 32,000 after the second, with higher rates observed in young males. Most cases are mild and resolve with full recovery. The study notes that COVID-19 infection itself carries a significantly higher risk of myocarditis, roughly 10 times greater than vaccination.
This work may inform the development of safer future mRNA vaccines while underscoring the established benefits of current ones in preventing severe COVID-19 outcomes.
[Cao, X., et al. (2025). Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination. Science Translational Medicine, 17(828)]
@BillyNotWillium@Pirat_Nation Do they make anything else? I mean there's a reason my town's video game store has a whole section for EA for $1 a piece.
@Pirat_Nation How is EA games not bankrupt yet?
I'm actually not even sure what they have in their library at this point that keeps them going? I might be outdated, but when I think EA, I think of its shit sports games
Xbox has reportedly canceled its planned Game Pass Family Plan.
The subscription would have allowed up to four users to share access to the full Game Pass library at a discounted rate.
It was tested in countries including Ireland and Colombia but was ultimately dropped after EA strongly opposed the shared library concept and its impact on game sales.
@IceIceBrand0n@Pirat_Nation Why that much cheaper? Sure you don't get something to physically hold in your hands but there's advantages too. A digital game can't be lost, chewed up, or stolen (easily). Not to mention it stays on your account if you want to play on another console. It should be $10 cheaper.
@Pirat_Nation Nintendo greedy asses should've been doing this the entire time.
Buying a "digital game" & not owning the physical copy of a game should be $20 cheaper.
Nintendo is going to charge less for digital Switch 2 games
Beginning in May 2026, and starting with preorders for Yoshi™ and the Mysterious Book, new Nintendo published digital titles exclusive to Nintendo Switch™ 2 will have an MSRP that is different from physical versions.
@xMBGx As someone who has both the regular and the Pro, gotta say it's not worth it. It's a tad faster and has a bit better ray tracing for $250. Totally not worth it especially because the disc drive is sold separately.
The PS5 Pro has been out for nearly 1.5 years, has over 100 Pro Enhanced games with more coming and has received a major upgrade with PSSR2.
Do you think it's been worth it so far or do you still think the Pro was a mistake?
@VivziePop I'd like to join the Hazbin Hotel discussions and receive news but it says I need approval. I'm a big Hazbin Hotel fan, even have the songs added to my list of music I listen to daily.
@Chime am I going to get my direct deposit tonight? The app says there are delays in deposits and if I don't get paid today, my credit score lowers because I won't be able to pay my bill.