Wei Su

51 posts

Wei Su

Wei Su

@WeiSu19

Postdoctor at stanford university. interest in the interplay of nerve system and immune system in disease contexts

Stanford, CA Katılım Şubat 2019
100 Takip Edilen38 Takipçiler
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Jonathan Kipnis 🟦
Jonathan Kipnis 🟦@jonykipnis·
In this Opinion piece with @boskovic_p and @gao_wenqing we are comparing immune system in the brain to a road construction crew and proposing that cellular immunotherapies may be the solution for neurodegenerative (and maybe psychiatric?) disorders || Will cellular immunotherapies end neurodegenerative diseases?: Trends in Immunology cell.com/trends/immunol…
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Yinpeng Zhan
Yinpeng Zhan@Zhanyinpeng·
One more beautiful work from Chi lab shocked me again 😉😉; they identified a population of brain-resident PD-1+ CD8+T cells that communicate with microglia via the CXCL16–CXCR6 axis, actually 'restricting' Alzheimer’s disease (AD) pathologies in human brain and mouse model. 👍👍👍 nature.com/articles/s4159…
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Nature Immunology
Nature Immunology@NatImmunol·
Chi and colleagues identify brain-resident CXCR6+PD-1+CD8+ T cells that interact with microglia to limit immune-mediated pathology in a mouse model of Alzheimer’s disease. Read it here: rdcu.be/dlBHw nature.com/articles/s4159…
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Wei Su@WeiSu19·
@NeuroSGS Okay! We used beta amyloid mouse models that T cell phenotype is quite unique in mouse brain parenchyma. If focus on human and Tau model, the phenotype could be different. I am looking forward to seeing ur new results. Good luck!
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Sammy
Sammy@NeuroSGS·
@WeiSu19 My work is in humans, with a particular focus on Tau pathology. We want to analyse brain-derived tau in plasma and correlate it with T-cells and markers of neuroinflammation (and assess their circadian regulation).
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Wei Su
Wei Su@WeiSu19·
@NeuroSGS Which AD models do u look at? b-amyloid or Tau? Based on the immune profile by flow cytometry, they are more stem-like memory phenotype instead of exhaustion based on typical flow markers for memory vs. exhaustion from chronic virus or cancer models. Good luck to your findings
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Sammy
Sammy@NeuroSGS·
Very interesting, but the protective role is surprising to me. We know CD8+ T-cells accumulate within the CSF and brain parenchyma, but they tend to correlate with cognitive decline. For part of my PhD, I’ll be looking at the sleep- & circadian-regulation of CXCL16 in plasma in Alzheimer’s patients (along with senescent and exhausted CD8 T-cell phenotypes). Will be more curious of my results now 🤔
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Keşfet

@boskovic_p @gao_wenqing @hongbo_chi @NatImmunol @AlonMillet @Jhledo @SohailTavazoie @ImmunityCP