Tonya Zeczycki

Working on some manuscripts and grants right now. Needed to see this.

Abbvie @abbvie announces that their once-daily drug, tavapadon, improves #Parkinsons patient mobility in late-stage study reuters.com/business/healt…

Check out the 2024 Emerging Investigators Issue for @J_ASMS. The future of mass spectrometry is definitely in good hands!! pubs.acs.org/toc/jamsef/35/…

@neely615 @Wybenga_Groot @UCDProteomics OH MYLANTA I have NO CONFLICTING MEETINGS. I'm locking my office door and ignoring any knocks, cries for help, or fire alarms. It has been too long.

Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out @NatureBiotech ! Read here👉: doi.org/10.1038/s41587… 🔬 Highlights: - Uses an experimental library of peptide markers integrated with a structural proteomics workflow. - Probes the assembly state of hundreds of protein complexes simultaneously across conditions directly from whole cell extracts, informing on binding interface occupancy. - Supports the structural modelling of protein complexes and the design of compounds targeting them Congratulations to shared first authors @CathyMarulli and Christian Dörig and thanks to our collaborators @LabBarral and @TorstenSchwede lab @ETH_en #Proteomics #PPIs #SystemsBiology #LiPMS #teammspec #DrugDiscovery

Rethink the analysis of DDA data! Blurring the boundary between DDA, WWA, and DIA, #MSFragger-DDA+ Enhances Peptide Identification Sensitivity with Full Isolation Window Search. Fully integrated in #FragPipe, simply annotate your DDA files as DDA+ and RUN. biorxiv.org/content/10.110…

The synuclein seeding assays are not enough to diagnose Parkinson and to differentiate it from PSP and MSA. Dr Edwin Jabbari @ucl makes a convincing argument that kinetics matter and combination assays will be the path forward. A combo assay that includes a 4R Tau assay has great potential. 1/3 of LRRK2 negative cases w/ current synuclein assay and also over 7% completely negative. Congrats on junior MDS award. #mdscongress #parkinsom

Working with my lab peeps and collaborator this week has, once again, reminded me why I love what I do and that I truly have the best "job" in the world.

I try not to brag about our papers when they come out, but for this one I make an exception. It is a clinical trial showing that our new drug combination is effective in pain patients. It will be published in Frontiers in Pain Research. @ECUBrodySOM @ECUResearch @RLSFoundation

@neely615 @MagnusPalmblad @ProteomicsNews This is why it was so much fun to do!

We are thrilled to share our latest preprint on the Anti-Müllerian Hormone and its unique signaling pathway. Our first ever cryo-EM structure represents a breakthrough over 40 years in the making. 🧬🔍 (@drewhow66) Check out our findings here: biorxiv.org/content/10.110… 1/10

👋A.M.A.Z.I.N.G. 👋 Refresher paper on Understanding isotopes, isomers, and isobars in mass spectrometry: #f0015" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl… Checkout! #isotope #isobar #isomer #massspec #metabolomics #multiomics #proteomics

@neely615 @ProteomicsNews This is making me realize I need to get....a passport. I know I know.

@neely615 Crap..yah sometimes it's later....

@neely615 What about the Biophys Society? (Note it is a big one) biophysics.org/2025meeting/pr… Protein Society is a little too late (june)

Very excited to see work from Hanna Budayeva included in this special issue of @JProteomeRes. Hanna has done a fantastic job leading our chemoproteomics efforts over the last few years - this story is just one of the exciting things her group is working on! Check out this issue!

@UCDProteomics Hmmmm....maybe there is a special test to establish this? Rack 5 boxes of tips in under a minute. Estimate the mM NaCl concentration in a saline solution to the nearest hundredth by taste. Strike fear in collegues with an eyebrow raise.

Curious how one becomes a "bona fide" researcher. Is there a o-link probe for this? I'd watch out for hook effects on this one. Maybe you could be so "bona fide" it comes back negative?proteomicsnews.blogspot.com/2024/07/41000-…

@UCDProteomics Ohhhh maybe I will jump over and give it a try.

@Zeczycki_Lab No, but the new version is great for taking notes

I'm loving the new version of paperpile! Honestly I think it's totally worth paying for especially since it's less than a vending machine candy bar around here per month paperpile.com

Important to de-stigmatize mental health efforts for Graduate Students. How PhD students and other academics are fighting the mental-health crisis in science nature.com/articles/d4158…