Zippin Lab

We are so excited about the promise of this work for patients with disorders of hypopigmentation such as albinism. Fantastic collaboration of intramural and extramural science. Congrats to Monika Dolinska for leading this study and to all members of the Brooks and Zippin labs.

@WeillCornell @WCMEnglanderIPM @PASPCR1 @ifpcs Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disorders insight.jci.org/articles/view/…

In this paper we also leverage our LC-MS melanin tracing technique to show that ampyrone activates new melanin synthesis within 20 minutes. We are excited to see how this approach will aid in the discovery of new therapeutics for pigment disease.

We excited about our recent publication in JCI Insight. Highlights the power of intramural and extramural collaboration between my lab and the Brooks labs at NEI. Amazing job by first author Monika Dolinska.

@SamCRichard Hi. We do not have a drug ready for human use yet. But the goal is to help those with oca1b. We are developing better drugs for this purpose.

@ZippinLab Is there any way that individuals with oca1b (my infant) can participate in these studies?

Melanin pigmentation of the skin and eyes has an essential role in the development of visual acuity and in preventing skin cancer risk. Inflammatory disorders of skin can cause significant depigmentation.

biorxiv.org/content/10.110… @PASPCR1 @WeillCornell

Thus, we have identified a new therapeutic approach for the treatment of diseases of hypopigmentation including OCA. In addition, we highlight how our LCMS tyrosine tracing technique can be used for in cell drug screening with changes in TYR activity seen in just 20 minutes

@WCMEnglanderIPM @PASPCR1 It’s a fantastic conference for those interested in melanocyte biology. Early bird deadline and abstract submission ends July 20th!!

Our @WCMEnglanderIPM colleague Dr. Jonathan Zippin (@ZippinLab) from the #WCM Dept. of #Dermatology will present on melanocyte biology at the 2024 Annual Pan American Society for Pigment Cell Research (@PASPCR1) on September 9th! Register today: web.cvent.com/event/3f59d26a…

@LyssiotisLab @UMRogelCancer @UMPhysiology @UMICHpancreas Well deserved!

Special thanks to Cis Maisel and the @UMRogelCancer for the honor and reception, as I was inducted as the Maisel Research Professor of Oncology. Thank you so much to the @LyssiotisLab, past and present, mentors, family, and friends for joining in the celebration. I deeply appreciate you all🙏☺️ If you missed it or are dying to relive it (Mom), don't worry, @YouTube has you covered: youtube.com/watch?app=desk… cc: @UMPhysiology, @UMICHpancreas, @MicheleLabUM

We are pleased to support selected trainees and young investigators through travel awards in the amount of $1,000.  A subcategory for DEI travel awards has been established through the generous donation from L’Oreal. Looking forward to seeing everyone this fall!

Registration is required to submit the abstract and attend in person or on-line. TRAVEL AWARDS

Fantastic Meeting in NYC. The PASPCR Annual Meeting showcases the current research in melanocytes, melanoma, melanin and disorders of pigmentation, and we invite you to submit abstracts for the conference being held September 9-12, 2024, in New York, NY, and also online.