Jakob Weiss

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Jakob Weiss

Jakob Weiss

@_JakobWeiss

DPhil student in Genomic Medicine & Statistics @UniofOxford by way of @broadinstitute and @bostoncollege. Amateur marathoner.

Oxford, England Katılım Ekim 2024
16 Takip Edilen11 Takipçiler
Jakob Weiss
Jakob Weiss@_JakobWeiss·
Delighted to share our @NatureCancer paper, out today, on determinants of ICB response in GBM (link in 🧵) With bulk and single-nucleus genomic profiling of 181 ICB-treated tumors, we found that tumor RNA subtype (and not TMB!) predicts survival and shapes acquired resistance.
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Jakob Weiss
Jakob Weiss@_JakobWeiss·
@GongDennis Nice work—another confounder that’s often overlooked is time of day the blood sample was taken. Lots of proteins vary in a circadian way and it can be predictively useful to look at deviations from the circadian prediction (see e.g. sciencedirect.com/science/articl…)
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Dennis Gong
Dennis Gong@GongDennis·
Overall, careful inspection of data can provide much more than naïve ranking by raw p-values. The full paper with more details (or if you just want to look at volcano plots for some common diseases) is linked here: docs.google.com/document/d/e/2… Lots more to discover.
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Dennis Gong
Dennis Gong@GongDennis·
A year ago, the UKBB released >53k plasma proteomes, allowing cross sectional analysis across hundreds of diseases and traits. Using a 2920-plex panel, we can quantify thousands of potential biomarkers. What is the best way to analyze this dataset?
Dennis Gong tweet media
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Jack Ghannam
Jack Ghannam@JackYGhannam·
Excited to share some of my PhD work out today in @NatureCancer! Integrating bulk and single-nucleus genomic approaches, we identify distinct determinants of survival and acquired resistance to ICB versus standard chemoradiation in glioblastoma. #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4301…
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Emilie Wigdor
Emilie Wigdor@EmilieWigdor·
📣 Preprint 🧵: we profiled post-mortem human BA22 (speech cortex) in autism across 100 donors using single-nucleus multiomics (~500,000 nuclei), integrating RNA + chromatin accessibility. Shout-out to my co-first authors @VarunSuresh007 and @YUHANHAO2: biorxiv.org/content/10.648…
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Barney Hill
Barney Hill@_barneyhill·
multi-omics is perversely selected for current academic incentives. you have large funding need (funders happy), you can produce multiple complex figures regardless of findings (journals happy) and you can naturally spread results across N papers (profs happy)
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JB Alberge
JB Alberge@JbAlberge·
1/ 🧵Check out our new study in @NatureGenet, which examines how precancerous conditions (MGUS/SMM) evolve into Multiple Myeloma, and offers new computational methods to predict progression risk and model cancer evolution. doi.org/10.1038/s41588…
JB Alberge tweet media
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Jakob Weiss
Jakob Weiss@_JakobWeiss·
@signulll US Bank Altitude Reserve has been a great daily use card. It’s closed to new applications but I’ve loved - 3% back on mobile pay and travel - $325 annual travel credit to offset $400 fee - PP lounge access, esp when abroad - 1.5x bonus when redeeming for travel - no balance min
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signüll
signüll@signulll·
2025 credit cards: - amex platinum for travel & lounges. - us bank 4% cash back for everything else. is there a better more simpler combo?
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Jakob Weiss
Jakob Weiss@_JakobWeiss·
@TimCoorens @emblebi Congrats Tim! Well-deserved. Hope I can visit sometime—do say hi if you're ever in Oxford.
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Tim Coorens
Tim Coorens@TimCoorens·
Very happy and excited to announce that I'll be starting my own research group at @emblebi! The group will focus on lineage tracing, somatic evolution and the origins of cancer. Interested in doing a postdoc in the group or know someone who is? Please reach out!
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