Eddie Rashan

As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime doi.org/10.1038/s41594…

@nieminm @tloch_ Congrats, Niemi Lab!! 🥳

New preprint from the lab, led by the ever-talented grad student Tessa Lochetto @tloch_! We find that loss of Pptc7 decreases lean mass, induces skeletal muscle dysfunction, and causes metabolic derangements in adult mice: doi.org/10.64898/2026.… /1

@tloch_ Congratulations, Tessa! Look forward to reading!

I am so excited to see my first, first author manuscript live on bioRxiv! I remember the day I went to my PI's office and said "I want to investigate the skeletal muscles of these mice" without any idea of how to necropy them. Striated muscle physiologist incoming!

The NeoChen Lab is recruiting and will start Oct 1, 2026 in Mol Bio Dept @UTSWMedCenter! Looking for creative+passionate techs, grad students, postdocs. We apply the lens of neonatal medicine to study #peroxisomes #mitochondria to advance the care of neonates and beyond. @BWFUND

New preprint! We find that fatty acid double-bond geometry alters their metabolic fate and ferroptosis sensitivity. Trans fatty acids are metabolized differently from their cis counterparts, reshaping membrane phospholipids and ferroptosis sensitivity. biorxiv.org/content/10.648…

The metabolic basis of regulated cell death dlvr.it/TTXSvs

HHMI released the official 2027 Gilliam Fellowship details, and a lot changed. Deadline's earlier this cycle: Oct 27. Int'l & MD-PhD students now eligible. Stipend up to 50K. New postdoc pathway adds up to 7 yrs of support. No Journal names!!!! yaelcourtney.com/resources-and-…

France v Morocco Quarterfinals but Scotland is still here!

Happy to share our new preprint from @RutterLab. To understand how genes are controlled, we developed a method we call TRoUT-FISH, using CRISPR + RNA-FISH. We found that glycolytic gene expression is fine-tuned by lineage specifying transcription factors. biorxiv.org/content/10.648…

Excited to share our new preprint from @RutterLab, identifying a melanosomal tyrosine transporter! biorxiv.org/content/10.648…

Happy to share our paper about localized signaling from lung cancer to sensory neurons in cachexia together with Michael Cross and @ThalesPapaG at @nyugrossman! Thank you to @dfg_public for funding my journey science.org/doi/10.1126/sc…

Thrilled to share this #lipidtime story in @JCellBiol where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!

Red Line passengers on July 21-30

Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP science.org/doi/10.1126/sc…

Now online! Mechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK dlvr.it/TT5zX0

Excited to share our new bioRxiv preprint! We introduce RIPPLE, a synthetic platform that couples reaction–diffusion circuits with protein condensation to generate tunable sub-cellular architectures. I’m deeply grateful to @MaggieXzj and @CellRaiser_ for their mentorship, collaboration, and support throughout this project. It has been a long but incredibly rewarding journey. biorxiv.org/content/10.648…

There are 19 types of cancer associated with obesity. But only a limited number have a very strong association. Two excellent review papers today @NatMetabolism nature.com/articles/s4225… nature.com/articles/s4225…

So excited our paper on mitochondrial phosphatidylinositol (PI) is finally out and chosen as an Editor’s Highlight in @NatureComms! PI is a known component of mitochondrial membranes, yet how its levels within mitochondria shape core functions, is unknown. nature.com/articles/s4146…

PI is a prominent #mitochondrial lipid but little is known about its regulation and function. In work led by @Zak_Bakes and Rachel Guerra, we discovered that Fmp30p is a PI hydrolase that affects IM protein organization and CoQ production. #HHMInews #WashU nature.com/articles/s4146…

Inflammatory cytokines induce new cancer dependencies @NatureGenet @broadinstitute @MangusoLab nature.com/articles/s4158…