Luke Harvey

Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.110…

Very excited to see our study on a case of ALL to AML switch after CAR-T treatment out in @NatureCancer! Using deep genome sequencing, we show the cancer switched cell types to escape therapy. @broadinstitute @sangerinstitute @getz_lab Thread below 🧵 nature.com/articles/s4301…

June really appears to be my lucky month - our new preprint is out on @researchsquare! 😍 Together with @doctor_msc, @andrewrjlawson and many others we looked into the life history of mitochondria in the human haematopoietic system researchsquare.com/article/rs-308…. [1/x]

@AndyRusss Awesome work Andy!

Single-cell or spatial? Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics ➡️ doi.org/10.1101/2023.0…

@M_B_Miller @BWHPath @BrighamWomens @harvardmed @harvardbrainsci @BWHNeurology Congratulations! Looking forward to more great work!

I am excited to announce the opening of the Miller Lab focused on #neurodegeneration research from the perspective of #SomaticMutations and #SingleCells! Find out more at: mbmillerlab.org @BWHPath @BrighamWomens @harvardmed @harvardbrainsci @BWHNeurology

➡️Delighted to share our latest work (read n’ share, it’s open access!): "Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells" #Cancer #ageing #polyposis @NatureComms nature.com/articles/s4146… 🧵[1/]

If you are interested in somatic mutations in non-neoplastic diseases, please check out our latest preprint in which we characterise the somatic mutation landscape of psoriatic skin medrxiv.org/content/10.110…

Amazing to be at #EACR2022 in person! Beautiful city & exciting science ahead. Very happy to represent the @imartincorena and Campbell groups @sangerinstitute together with super⭐️ @_Luke_MRH_. If you are around, would be fantastic to see you join for our talks on Wednesday 🥰

Amazing work by Alex and Adrian asking fundamental questions about somatic mutations and ageing. A privilege to have a played a small part in this great story.

Delighted to share our latest work in its final form (and open access!). Here, we studied the rate at which somatic mutations accumulate in different species to address some long-standing hypotheses. 🧵… 1/ nature.com/articles/s4158…

@CamCompOnco @CRUK_CI @gladyspoon1 @mireiacrispin @paulpharoah @bioinpharmatics @MarioniLab @markowetzlab Looks great! Do we need to register?

THJE COUNTDOWN BEGINS ... The Cambridge Comp Onco Community meets on March 25th at @CRUK_CI Talks by @gladyspoon1 @mireiacrispin @paulpharoah Come and join us! Organisers: @bioinpharmatics @MarioniLab @markowetzlab

Delighted to share our new pre-print: ➡️Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells⬅️ #Cancer #polyposis #ageing #Genomics biorxiv.org/content/10.110…

Out today @Nature! Human tissues accumulate cancer-driver mutations with age, yet tumor formation remains rare, why!? We show that mutant clones in the normal epithelium can have a tumor-protective role by outcompeting and eliminating nascent tumors. nature.com/articles/s4158…

Delighted to share our paper ➡️Increased somatic mutation burdens in normal human cells due to defective DNA polymerases go.nature.com/3kUQVJy Implications for our understanding of cancer risk and the somatic mutation theory of #ageing 🧵⬇️

How does a single cell generate different organs and tissues of the human body? Do early cells contribute equally? Do embryonic patterns differ between people? Sequencing normal cells reveals the developmental stories hidden in their DNA @NaturePortfolio nature.com/articles/s4158…

Thrilled to share our paper on the mutational landscape of human somatic and germline cells @Nature. We integrated histology and genomics to explore the genetic diversity that develops within our bodies as we age. nature.com/articles/s4158… An illustrated tweetorial… [1/15]

I am incredibly excited to share our preprint ‘Somatic mutation rates scale with lifespan across mammals’In this paper we provide an unprecedented description of somatic mutation across mammals. biorxiv.org/content/10.110… An illustrated tweetorial…[1/17]

#GenomicsLite is back this week, look at how cancer is researched in the lab - from tumour to treatment. We'll be joined by @PJaaks and @_Luke_MRH_ from @sangerinstitute. Sign up: bit.ly/GL-6May

A tour de force of insights into immune cell development by @heatherEmachado

So proud of this new study. We developed naive and memory B and T single-cell expansion protocols and produced lymphocyte and blood stem cell genomes, from healthy individuals aged 0-81. I am still stunned at the biological insights revealed. [1/10] biorxiv.org/content/10.110…