Jack Nicoludis

KnotFold enables AlphaFold2 to correct mispredicted connectivity patterns in disulfide-rich peptides by mutating conserved cysteine residues in multiple sequence alignments to simulate protein coevolution. Read the paper: go.aps.org/4f9zmOL #MLSB @workshopmlsb

@sfboehner @Trevor4SF What was factually incorrect? Also, you clearly have never biked in the city. No cyclists is going to bike up the massive hill on dolores (or Church, Guerrero) than on very flat Valencia. Also, Valencia is a major place to shop and eat, cyclists want to go there.

@_jackn_ @Trevor4SF However I agree we need more enforcement for traffic violations.

I’m excited to see a consensus emerging about next steps for the Valencia St Bike Lane! Protected bike lanes with ‘floating’ parklets will ensure safe cycling and allow small business to keep their important outside dining areas. sfchronicle.com/sf/article/s-f…

@sfboehner @Trevor4SF You said church is “safer.” Why is Valencia unsafe for cyclists? Most cycling accidents are caused by drivers not following the rules of the road -> they are breaking the law. Let’s enforce road laws

@_jackn_ @Trevor4SF Breaking the law? What are you talking about.

@sfboehner @Trevor4SF Safety from what? Are you saying it is a cyclist’s responsibility to protect themselves from people breaking the laws? Or should we make laws and enforce them so that people don’t injure others?

@_jackn_ @Trevor4SF From a safety perspective church is the better option.

@sfboehner @Trevor4SF people bike to stores and restaurants on valencia. Church has the muni - muni tracks can be a hazard for bikes. It is also more hilly than Valencia. Why not block Valencia off to cars and have cars drive on Guerrero - it already has two lanes each way and no bike lane.

@Trevor4SF This is still a bad idea, move the bike lane to church it's less busy.

@Shenanigans_ATL @Polonius_SF @Trevor4SF Why can’t Valencia be one way? By not having two way car traffic you could accommodate more parking, have parklets and bike lanes. I guess the struggle would be getting SFFD on board, but they could use the bike lane as they do now. Divert traffic to Guerrero

@Polonius_SF @_jackn_ @Trevor4SF Nailed it. Floating parklets are all about bending to merchants demands of saving every possible parking space which is how we ended up in the center bike lane mess to begin with.

@Trevor4SF I dislike the center bike lane because it has created unusual traffic patterns that encourage bad behavior in both drivers and cyclists. But having cyclists weave between restaurants and the parklets seems like it will discourage cyclists from using it…

@Trevor4SF I’m not sure I understand the “floating” parklets. Does that mean the bike lane will be between the restaurant and the parklet such that pedestrians will be frequently crossing it? That seems dangerous and inconvenient for cyclists. It will make pedestrians angry with cyclists.

@BetterValencia Also noting that the person biking fell into the travel lane where, if there was a car/truck driving there, they would have been run over and potentially killed. Sandwiching people between two lanes of driving cars/trucks is a dangerous idea, and this bikeway should be replaced.

The Valencia center bikeway is causing head-on collisions between people, resulting in serious injuries. Mayor Breed and SFMTA should replace the center bikeway with curbside protected bike lanes or pedestrianization immediately. Please take action now: BetterValencia.com

I’ll be at @workshopmlsb at #neurips2023 this Friday and have a PhD internship position in my group this coming summer. Say hi if you are interested! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…

Can I simultaneously hate the Valencia center bike lane while also doubting that the removal of parking spaces on Valencia caused 80% loss of a business on Valencia? Let’s make Valencia one way with a protected bike lane and lots of parking spaces and loading zones!

Thanks @SFMTA_Muni. Your design is working as intended.

@sokrypton There are open source variant effect predictors that perform worse than AlphaMissense, so wouldn’t the responsible thing be to release the best model to the public?

Interesting excuse... 🤔 hopefully this is not the start of closed source software in the field... "As part of our commitment to releasing our research breakthroughs safely and responsibly, we will not be sharing model weights, to prevent use in potentially unsafe applications."

Ok, so who is going to train OpenMissense to get them to change their (deep)minds about this?

@slushbumps @LukeBornheimer @BetterValencia love this idea!

@LukeBornheimer @BetterValencia Make Valencia a one way with a dedicated pick up lane and parking on both sides with a protected curbside bike lane.

What happens to the Valencia Street center cycle track when a vehicle obstructs the driving lane? Exactly what you expect. This wouldn’t happen with curbside protected bike lanes (@BetterValencia), which are better for safety, business, and climate. Please end the “experiment.”

@drdre4000 @mary_munson4 Christian Anfinsen went to Swarthmore to get a chemistry degree!

I’m trying to come up with a list of well-known chemists who got their undergraduate degrees at PUIs (I can think of Richmond Sarpong and Emily Balskus currently). Can ya’ll comment any you know of?

@jjschultz @gamescan @SFMTA_Muni I don’t have big issues with the idea of a center lane. My issue is the implementation has been horrible, the lane isn’t protected at all, the curbs are dangerous for cyclists, and there’s no engineering controls for drivers who won’t obey rules (left turns, entering bike lane)

@gamescan @SFMTA_Muni the center lane rules! I know it's super fashionable to hate on it, but I bike on Valencia regularly and think it's awesome. Curbed "protected" lanes are more dangerous as pedestrians cross them without looking and cars turn into them without looking.

How much money has @SFMTA_Muni budgeted for lawsuit settlements? Given that multiple experts have cited issues with the design, and SFMTA's lack of effort to keep drivers out of the bike lane, I can only imagine that any injury claims are going to be slam dunks.

SFMTA insists that people on bikes “share the road” with cars on Valencia while SFMTA installs its unprotected center cycle track that’s supposedly “closed.” I followed SFMTA’s guidance; look and see what it got me. The center cycle track is flawed; the rollout is almost worse.