Matthew Lalli

Our new single-cell CRISPR-based functional genomics paper is live @genomeresearch! Thanks Denis Avey, @joeddougherty @CarpeRibosomam, Jeff Milbrandt, and Rob Mitra and all my fantastic colleagues @WashuGenetics glimpse.link/l/OjUpUw9

Today, I am thrilled to introduce @PerturbAI_Tx, a company I co-founded to rethink drug discovery. Biology is complex, and disease unfolds across genes, cell types, and tissues. We’re powering AI with the causal logic of human genetics: perturb.ai

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Bioeng Custom Lab Hardware Turn Key Genetic Design Please RT 💚

Ever wondered how mechanical forces contribute to early cell fate decisions in development? Congratulations to Jiwon Jang and his lab at POSTECH on their beautiful work. nature.com/articles/s4155…

Does anyone have a reference for interference between Ef1a and U6 promoters? @JohnDoench, maybe?

Making it easier than ever to get started, @Addgene has now released the reagents as a kit- addgene.org/kits/mitra-bar… Many thanks @Addgene, and again thanks to everyone involved in this work! @UrvashiThopte, @arnavm1

An exciting day for barcoded calling cards! Our new method lets you simultaneously measure transcription factor binding sites and gene expression changes- academic.oup.com/nargab/article…

@jennieerinsmith matthew.lalli@mssm.edu

Happy to share this new paper on published in @AJHGNews from the Commission on #Neurodevelopmental #CNVs. Such gratitude to all the commission members! @Ring14USA is a founding member along w/@chromosome8p and @dup15q Link: tinyurl.com/CNVRoadmap.

Very happy to share our recent publication on the functional mapping of non-coding variants in human neurons ⁦@CellReports⁩. Very proud of my wonderful students and postdoc, Carlos Sanchez-Priego, Ruiqi Hu, Linda L. Boshans ⁦@SWilliNeuro⁩. cell.com/cell-reports/f…

A recent publication from our lab with great collaboration from @emukamel & @DrachevaStella teams! Quantifying major drivers of #RNAediting variability in the human brain. Congrats to all, including @CuddlestonRyn @aMattScientist and all co-authors! nature.com/articles/s4146…

Please register to hear about the latest progress in identifying common pathways affected in autism. I'm psyched and humbled to be a part of this amazing line-up of scientists!

An improved version of our barcoded calling card method is now available. Special thanks to the new contributors Allen, Arnav (@arnavm1) and my extraordinary research associate Urvashi (@UrvashiThopte)! biorxiv.org/content/10.110…

We are committed to eliminating barriers and increasing access to education and careers among students groups that are under-represented in science 🔬 and medicine 🩺 or are from economically disadvantaged backgrounds. 💰Learn more & donate to support: giving.mountsinai.org/goto/Seaver

The @BBRFoundation selected 2 #SeaverTeam members to receive 2021 Young Investigator Grants! These grants support work of early career investigators with ideas for groundbreaking neurobiological 🧠research. 🎉👏Congrats @aMattScientist & @KeerthiRajaman1! bbrfoundation.org/sites/default/…

Congratulations to @SeaverAutism awardees @KeerthiRajaman1 and @aMattScientist! 👏

The #BrainFoundation selected #SeaverTeam Director, @buxbaum_joseph, as a 2021 BRAIN Research Awardee!🎉🧠 His team will identifying shared pathological pathways of #autism-linked genes & search existing compounds that have potential to revert altered pathways to healthy states.

Interested in #epitranscriptomics #RNA in #CNS cells? Check out our new preprint by @CuddlestonRyn Junhao Li & Sinja Fan with Alexey Kozenkov @aMattScientist, Shahrukh Khalique, Stella Dracheva & @emukamel: Cellular and genetic drivers of #RNAediting variation in the brain 🧠👇

This work builds upon the brilliant pioneering efforts from the Mitra and Dougherty labs (@CarpeRibosomam) led by @arnavm1 and @AlexCammack. #SRT sciencedirect.com/science/articl… pnas.org/content/117/18…

Studying a transcription factor and want to know its genomic binding sites and which genes it regulates? Our new method lets you do both, at the same time! biorxiv.org/content/10.110…

Read below to find out how @aMattScientist can revolutionize your favorite method, Calling Cards, to become much more time, personnel, and cost effective, and honestly just way cooler!! Congrats to Matt, and collaborators at Mitra lab! biorxiv.org/content/10.110…