arnavm.bsky.social

I hadn't seen a version for genomics yet.

Here's the thing. We have **NO IDEA** how to pick good graduate students. I served on admission committees for 10+ years, and chaired a few, and what I learned is that all the spreadsheets of grades and test scores and recommendations and essays and publications and interview rubrics are just an elaborate ruse to pretend we know what we're doing when we simply don't. Many of the most highly ranked applicants to our "top" program flamed out quickly, and tons of the students we summarily rejected have turned into amazing scientists. But in the name of creating meritocratic seeming rankings that are more about creating a workforce than great scientists (a system that anyone paying attention knows is bullshit), we've created a homogenous process adopted by nearly all institutions that has stamped out the one thing we should be striving for - given our lack of any clear understanding of what leads to success - a wide range of difference talents and experiences.

Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. biorxiv.org/cgi/content/sh…

Haven't been as productive academically lately due to being back in residency, but here's a GitHub-style heatmap of how times I've been paged each day.

Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…

I just wrote a review on transcriptional regulation and I want to talk about something that has been bothering me for 5 years, which ended up changing how I think about science in general. A brief thread: authors.elsevier.com/sd/article/S09…

“The question was, would lessons in a field far from their own make them better at the observational and diagnostic skills that lie at the core of ophthalmology? And the answer is that it did, substantially.” aaojournal.org/article/S0161-…

New achievement unlocked: survived my first overnight call!

@morris_lab @NatureBiotech @DrawImpacts @kjkjindal Yay, congrats!

CellTag-multi is finally out in @NatureBiotech nature.com/articles/s4158…. We didn't make the cover this time, but I love what we put together with @DrawImpacts! Here's our fun vision of CellTag cell barcoding and capture across single-cell RNA-seq and ATAC-seq @kjkjindal

@jcdelo The original peer-to-peer

Napster was first, then KaZaA, then LimeWire. Get it right.

I don’t know what I was expecting

A lab member is trying to establish a timeline for enhancer studies covering discovery, identification, activity, & enhancer-gene connectivity. Are we missing something that we must add to the timeline? @generegulation @AllAboutTFs @ChromatinHaiku #epigenetics #Chromatin

We present: 'Multispectral live-cell imaging with uncompromised spatiotemporal resolution'. biorxiv.org/content/10.110… 1/16

@arjunrajlab To be fair, I asked for an answer in miles

Nice try

Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/

@jaredvgoodman @WashUDPS @NIH @NIAIDNews @MS_ResearchDoc @WashUNeurology @wusm_pathology Congrats!

@arjunrajlab I'm a sucker for historical perspectives, so this was a delightful find: ncbi.nlm.nih.gov/pmc/articles/P…

I knew that WNT = wingless + integrin, but didn't think that was the reason we say "wint" instead of "double-eww-en-tee"—makes sense! Is is generally the case (for genes) that we say the individual letters of acronyms, but try and wordify ones that come from, well, words?

A reminder of what Twitter used to be like nytimes.com/2024/05/26/nyr…

Why is pooled oligo synthesis so expensive? What are the current bottlenecks to cheaper oligos?

Do you really need to spread plasmid libraries on mountains of plates to get uniform growth, or can you just dump them in a flask and call it a day? We make huge plasmid libraries in the de Boer Lab, so we tested whether culture method really matters. 1/ biorxiv.org/content/10.110…