AK

to strive to master what will be contradicted the next day, to fear and hope intensely on shaky evidence, is surely an ill use of the mind

Today’s KRAS win didn’t start today. It took decades. Daraxonrasib nearly doubled survival in pancreatic cancer. That’s extraordinary! But lets zoom out for a sec: ▪️KRAS was called “undruggable.” ▫️NIH quietly poured ~$172M behind it. ▫️Funding grew 9x. 💡One insight (Shokat lab, 2013) changed everything. This is how breakthroughs are supposed to work: public money → basic insight academic labs → first leap industry → drug + survival curve Today’s headline has MANY authors. Congrats to @Revolution_Med and every scientist who stayed on KRAS when it looked impossible. 🎈this is what compounding science truly looks like = = = = = Source: NIH RePORTER via @Jori_health = = = = =

@LocasaleLab My wife was on this trial. Stage 4 panc cancer, 40 years old. She was in this trial and lived 18 months after chemo stopped working. We took trips to Spain, Disney, Jersey Shore. She got two more birthdays with our kids. Shove your hype and misrepresentation up your ass.

Finally, best news of the morning (and something you didn't expect so soon)... Revolution Medicines $RVMD daraxonrasib Ph3 results in second-line pancreatic cancer. Median overall survival in ITT patients (KRAS mutants + wild type combined) Dara 13.2 months vs chemo 6.7 months. OS Hazard ratio 0.40

The NYT published a link to critical original reporting on Iran 45 minutes ago. A good, fair story. They have 53m followers. The engagement metrics you display say they got 94 likes and 33 retweets out of that. Is that accurate? And if so, shouldn't you work on a better algo?

@Proofbytweet Brutal work life balance

What is a real estate novelist

@TheStalwart It feels hard to imagine now but, a lifetime ago, when Twitter still ran on a social graph of sorts and before the TikTok “revolution”, you could scroll to the end of your feed and get a message saying “that’s it, you’re all caught up for today”.

This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.

My favourites are the names Miranda (must be admired or wondered at) and Amanda (must be loved).

!!!

not surprising but a good illustration politico.com/news/2026/03/2…

Exciting data for sure. The caveat is that most of these pts probably did have significant atherosclerosis, since anyone who has had T2DM for 10 years likely does, but imaging to detect athero was not part of the study. Still, impressive result.

Lower, lower, lower, lower

same

Just some innocent Jewish shepherds tending to their flocks, connecting to the Land of Israel, imbibing the spirit of the forefathers in Judea and Samaria, and engaging in traditional Shabbat activities just before their seudah shlishit (Mukhmas, Saturday 29th March, 2026)

what are you doing with your unemployment? says: you know, running, making dinner, reading does:

My most popular Sora video was “an Elaborate regency romance where everyone is wearing a live duck for a hat (each duck is also wearing a hat), a llama plays a flute, prestige drama” I am not sure why OpenAI has decided their compute has more valuable uses. Really a mystery.

The $PFE/ $VALN Lyme vaccine was a product for which there was a lot of hope. Results today show OK efficacy. Vaccine efficacy landed at 70%; investors hoped for 80% but thought as low as 60% would be relevant. But the bigger issue is a statistical one. The main goal of the study included a specification on the lower confidence interval -- basically an estimate of the lowest the efficacy could possibly be -- and it missed. That could lead FDA and other regulators to demand another trial. The companies say they will submit anyway. But that's why Valneva shares are down 30%+. Given all the dynamics around RFKJr, the FDA, and the CDC, this will be a very interesting story to watch. I just updated our story with a quote from the noted vaccine expert Kathy Edwards. She calls the study "encouraging news" but said the study was "underpowered and the confidence intervals are wide." She's not sure what regulators will do. statnews.com/202623/lyme-di… via @statnews

INSANE: CCTV footage shows hundreds of Israeli settlers storming the village of Jalud in the West Bank before launching their pogrom, attacking Palestinian homes and setting them on fire in an attempt to burn people alive.

The FDA's Deputy Director of the Gastroenterology Division in CDER's Office of New Drugs Juli Tomaino is leaving too—after 13 yrs at FDA during 4 different administrations incl POTUS's 1st term. $IBB $BBC $XBI

Justice for Marty