Anna Köferle

Interested in exploiting genetic dependencies for the treatment of cancer? We are looking for collaboration partners! The call is still open until 12th September 2023. opnme.com/opn2experts/cr…

@yogeshgoyallab @arjunrajlab @Nature @pennbioeng @NorthwesternU Very interesting read! Lentivirus will have a preference for inserting itself into open/active regions of the genome. Did you look at the insertion sites of the barcodes and how these may contribute to the "predestined resistant fate" of a given clone? @arjunrajlab

So excited to share our work with @lane_andy on Y chromosome loss in cancer! authors.elsevier.com/a/1hKLcL7PXmcx-

We are looking for collaboration partners! Please submit your proposals for promising tumor-specific genetic dependencies here: opnme.com/opn2experts/cr…

@humantechnopole @martinlukacisin

Best thing about my visit to @humantechnopole so far: bumping into old friends on the shuttle bus

On my way!

New paper with @idmehta @naar_k @David_J_Adams in @trendscancer. We review methods for identifying synthetic lethal interactions between paralogs in cancer and discuss some of the challenges of exploiting them for the development of targeted therapeutics sciencedirect.com/science/articl…

Looking for a Research Laboratory Scientist to join our team @Boehringer (Vienna, Austria). Target identification. Cancer drug discovery. Great work environment. Please apply via tas-boehringer.taleo.net/careersection/… (and spread the word)

Happy to share! ARTi - a new method for highly stringent target validation overcoming limitations of traditional RNAi and CRISPR. Big thanks to @johannes_zuber for a fantastic collaboration! Precision RNAi using synthetic shRNAmir target sites biorxiv.org/content/10.110…

Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling. nature.com/articles/s4301… Thanks to a fantastic team! #teamscience #Her2

Excited to share our latest work on the control of ribosomes that is out today in @Nature. We found that osmotic stress leads to phenotypic diversification of yeast populations through an intron in a ribosomal protein gene. @UniCologne, @ISTAustria. nature.com/articles/s4158… 1/n

Happy to share! Paralog genes in cancer. Experimental validation of paralog pairs (RPP25/L, DNAJC15/19, DDX3X/Y and more): Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes cell.com/cell-reports/f…

Latest pre-print just out on bioRxiv "Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sex chromosome encoded genes" biorxiv.org/content/10.110…

This simple #SARSCoV2 saliva test costs $1, gets results in <1 hour, and can be performed anywhere without electricity medrxiv.org/content/10.110… by @PrakashLab Why isn't there US support to get rapid validation of such tests and provided to every household?

altmetric top 100 articles for 2016: altmetric.com/top100/2016/

Our current top 3 downloads: Epigenomics, NGS technologies & transposable elements go.nature.com/2g62Zny

this must be one of the coolest projects ever! kickstarter.com/projects/27673… @TeamFoldscope

bmcgenomics.biomedcentral.com/articles/10.11… twitter.com/JavierHerrero7…

@biotop_co pnas.org/content/113/34…