Dr. Ana Nikolic

Tempered Optimism: Advances in the Precision Medicine Era for Pediatric Low-Grade Glioma academic.oup.com/neuro-oncology…

How do you publish this tree and claim it's a success???!!!

Great points here, emphasizing the various degrees of cognitive engagement with AI/LLM use.

We have performed germline MLH1 hypermethylation testing for Lynch syndrome in >400 individuals. Using long read sequencing, we have identified MLH1 promoter mutations associated with Constitutional MLH1 promoter hypermethylation in one of the largest studies to date!

Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies dlvr.it/TSX1Ys

Presented at #ASGCT2026: A neuroepithelial tumor occurred in a child who had previously received AAV gene therapy for mucopolysaccharidosis type I. Analysis of tumor tissue showed the integration of rearranged AAV vector elements in the gene PLAG1. Read the full report: nej.md/4cXAAPt @ASGCTherapy

Physician-scientist pipeline is a retention problem, not a recruitment problem. We lose people in years 5–6 when revisions stack and RVUs absorb protected time. This month's JCI editorial names the connective tissue departments don't fund. doi.org/10.1172/JCI206…

Nature research paper: Synthetic super-enhancers enable precision viral immunotherapy go.nature.com/4cuHuLA

PLOS Biology: Formalizing our commitment to code sharing journals.plos.org/plosbiology/ar…

(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇 biorxiv.org/content/10.648… biorxiv.org/content/10.110…

In 1999, Tom Maniatis discovered something remarkable: neurons achieve self-avoidance via stochastic methylation of the protocadherin gene cluster. We've just discovered this locus is an evolvable in-vivo barcode across the human tissues: biorxiv.org/cgi/content/sh… 🧵

Ten simple rules for teaching data science arxiv.org/abs/2602.02874 1: Teach data science by doing data analysis 2: Use participatory live coding 3: Give tons of practice and timely feedback 4: Use tractable or toy data examples 5: Use real and rich, but accessible data sets

This is devastating news - Mike was a kind and generous human and classmate and incredibly talented clinician.

@sarthak_s @HotchkissBrain @UCalgary @jeffbiernaskie Congrats!

2 patients. Same surgery. One goes home same day. The other needs APS, admission, multimodal analgesia beyond opioids, and slower return to work. Why? One answer may be RUNX1 genetics. Our collab @HotchkissBrain @UCalgary with Dr. Tuan Trang and @jeffbiernaskie shows that RUNX1, via microglial regulation, shapes opioid analgesic response, withdrawal and links biology to real world perioperative pain variability. Big step towards predicting opioid responses and developing personalized pain plans!

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element biorxiv.org/content/10.648…

The @ENCODE_NIH Phase 4 Registry of candidate cis regulatory elements (ccREs) (2.37 million human and 967,000 mouse cCREs) is officially out screen.wenglab.org nature.com/articles/s4158… Congrats to @MooreJillE @ZhipingWeng & everyone else. Lots more incoming ...

What method should you use to track migrating cells? Read "Methods to analyze cell migration data: fundamentals and practical guidelines" to find the best cell tracking tool. Download the paper here: nature.com/articles/s4159…

🎉 Our systematic benchmark of spatially variable gene detection methods is out in @GenomeBiology! link.springer.com/article/10.118… We compared major methods so you don't have to. Hope this helps guide your spatial analysis or inspire better methods! Huge congrats to the amazing team 🙌

Get your abstracts in by Friday if you want to be eligible for a talk! We also have many poster prizes that we award and the abstracts also need to be submitted by Friday. The poster sessions are always exciting and buzzing with energy!