Andrew Wilkinson

This guy from The Netherlands emailed me asking if I'd come on his podcast. I didn't want to, so I used my usual line: "I'll only do it in person in Victoria." Welp, the SOB called my bluff. Flew 12 hours, mic in hand. Well played, @WouterTeunissen. It turned out great:

"We suffer more often in imagination than in reality." — Seneca

Someone built a Google translate for Linkedin 😭

"When these new businesses come in, there are huge advantages for the early birds. And when you’re an early bird, there’s a model that I call “surfing” – when a surfer gets up and catches the wave and just stays there, he can go a long, long time. But if he gets off the wave, he becomes mired in shallows." –Charlie Munger

Be the Barnacle on a whale. A principle from @awilkinson, based on attaching to a moving vehicle of progress. A very important business principle I have been thinking about applying to my own ventures, so for example talking about someone really famous on a youtube video.

Every time you get a cancer biopsy, the lab makes a tissue slide that costs about $5. It shows the shape of your cells under a microscope, and every cancer patient already has one on file. There’s a much fancier version of that test called multiplex immunofluorescence (basically a protein-level map showing which immune cells are near your tumor and what they’re doing). It costs thousands of dollars per sample, takes specialized equipment most hospitals don’t have, and barely scales. But it’s the kind of data oncologists need to figure out whether immunotherapy will actually work for you. Right now, only about 20 to 40% of cancer patients respond to immunotherapy, and one of the biggest reasons is that doctors can’t easily tell whether a tumor is “hot” (immune cells actively fighting it) or “cold” (immune system ignoring it). Microsoft, Providence Health, and the University of Washington trained an AI to analyze the $5 slide and predict what the expensive test would show across 21 different protein markers. They called it GigaTIME, trained it on 40 million cells in which both the cheap slide and the expensive test coexisted, and then turned it loose on 14,256 real cancer patients across 51 hospitals in 7 US states. The results landed in Cell, one of the most selective journals in biology. The model generated about 300,000 virtual protein maps covering 24 cancer types and 306 subtypes. It found 1,234 real, verified connections between immune cell behavior, genetic mutations, tumor staging, and patient survival that were previously invisible at this scale. When they tested it against a completely separate database of 10,200 cancer patients, the results matched up almost perfectly (0.88 out of 1.0 agreement). Nature Methods named spatial proteomics (mapping where specific proteins sit inside your tissue) its Method of the Year in 2024, and specifically cited GigaTIME in a March 2026 update as a model that “democratizes” this kind of analysis. The full model is open-source on Hugging Face. Any cancer research lab with archived biopsy slides, and most of them have thousands, can now run virtual immune profiling without buying a single piece of new equipment.

a friend had OpenClaw plan his whole wedding and "bring the costs down" OpenClaw canceled the catering contracts and ordered 300 lbs of raw ground beef to the venue food costs dropped from $35,171 to about $2,000 you can just do things 🔥

i mean this story is insane. man used chatgpt to sell his house in 5 DAYS. got 5 offers in 72 hours. no real estate agents. saved so much money doing it too. he used AI to: > price the house (researched neighboring properties for sale) > wrote up the legal contracts (saving him $500/hr lawyers) > best part: MARKETED the fucking property for him (usually you pay estate agents for their network of buyers - ChatGPT did all of this) i honestly thought sales people would be hard for AI to replace (you need to know people) but apparently not

this is so fucking wholesome guy used AI to save his cancer-ridden dog by sequencing its DNA and creating a CUSTOM cure. the tech behind this is fucking awesome (well done @demishassabis and the google team): - used CHATGPT to sequence dogs DNA discovers mutations - ran the mutations through Google’s Alphafold (AI protein sequencer) which CREATED A CUSTOM VACCINE TO TREAT THEM. - treated dog and reduced tumour by 50% in WEEKS. dog is alive and well. - this is the 1st time AI has been used to create a custom vaccine for a dog (and it worked) - dude is now working on similar vaccines for humans using AI! 2026 is definitely the year we see AI change personalised medicine in a HUGE way so sick

I’m going to be in LA for the next few weeks. Anyone want to hang out or do a meetup? Also: I need a pickleball crew in Venice 👀👀👀

Every couple thinks their fights are unique. They're not. High neuroticism + low agreeableness = explosive arguments. High conscientiousness mismatch = the silent seething kind. Your personalities wrote the script before you even met.

@danshipper @every Whoa! Nicely done

20% MRR growth for @every the last 30 days—all organic so proud of this team! major new launches coming the next two weeks too stay tuned!

"Civilization advances by extending the number of important operations which we can perform without thinking about them." — Alfred North Whitehead 👀

"The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore all progress depends on the unreasonable man." — George Bernard Shaw

Last month, my girlfriend and I sat in our den reading a report out loud to each other, line by line, with our jaws on the floor. It was breaking down our relationship dynamics with surgical precision — why we fight about the things we fight about, our blind spots, and how our personalities interact. The crazy part? It came from a personality test I built. I asked ChatGPT: "What information would you need to become the ultimate personalized relationship coach?" It gave me a list of 28 research-backed assessments — Big Five personality, attachment styles, ADHD screening, anxiety, trauma, values, and more. They were all online but scattered across clunky PDFs. As someone with ADHD, doing them one by one was torture. So I combined them into a single test that takes under an hour. 5,000+ people have now taken it. Here's what's happened: 💬 One woman said it was “spectacularly transformational” for her and her brother — it brought them closer than ever through vulnerable conversations they’d never had before. 💑 271 couples have done the comparison report together. It predicts your top 5 most likely fights and gives resolution tips. 📊 31% of users flagged on at least one Dark Triad trait 👀 42% showed minimal depression. But 22% showed moderate to severe — this tool is finding people who need help. 🧠 All my entrepreneur friends keep finding out they have ADHD 😂 It's called Deep Personality. We launched on Product Hunt today and I'd love your support 🙏 (It's #4 on the homepage, I'd really appreciate an upvote!) It costs less than a single therapy session and it might blow your mind.

@ProductHunt Update: #4!

Woo! My crazy personality test, Deep Personality, just hit #11 on @ProductHunt. Upvotes appreciated, nerds!

“The economy is not a pie, it’s a garden. Technology is rain.” –David Sacks (@DavidSacks)

It’s extremely good that Anthropic has not backed down, and it’s siginficant that OpenAI has taken a similar stance. In the future, there will be much more challenging situations of this nature, and it will be critical for the relevant leaders to rise up to the occasion, for fierce competitors to put their differences aside. Good to see that happen today.

I’m in Scottsdale for a bit tomorrow. Who wants to grab lunch?

"We are what we repeatedly do. Excellence, then, is not an act, but a habit." — Will Durant

My new favorite insult is calling someone’s job a Claude skill.