Roya Bashier

@flscientist @aaronmring I’d be interested to see what the downstream effects are of those off-target effects. Something Olink would be really good for

@bashier_roya @aaronmring It is but at the same time I’m not surprised considering the limited validation of newly generated antibodies outside the target it is intended to bind to

Fantastic work 👏 from @aaronmring lab showing specific binding of FDA-approved tx antibodies to unintended targets in 28% of Abs tested. E.g Pembrolizumab doesn’t bind PD-1 only but TDGF1 surface protein. This could lead to unexpected toxicity or mecanism of action.

If you’re looking for an Assistant Professor position, in immunology, metabolism, and aging- come join us in Madison! The metabolism community is outstanding and spans the entire campus. jobs.wisc.edu/jobs/immunolog…

Complex de novo structural variants are an underestimated cause of rare disorders | Nature Communications nature.com/articles/s4146…

Nature Neuroscience is happy to now offer Transparent Peer Review, in which authors can choose for us to publish details about the peer review process (including reviews, rebuttal letters, and editorial decision letters). More info at the link below: #transparent-peer-review" target="_blank" rel="nofollow noopener">nature.com/neuro/editoria…

I am often asked what the one skill is that young scientists should work on the most. My answer: your storytelling via presentations. The better you present, the more your ideas travel, the more doors open, and the more people want to work with you. A few tips: Have one clear storyline that you want people to remember. Repeat it. Build your talk around it. Your slides are there to support you, not to talk for you. Think about the best TED Talks...if a slide has more than 10–15 words, it’s a distraction. Engage the room with confidence. Don’t hide behind the podium. Stand in front of your audience, make eye contact, and own the stage. A strong talk is a multiplier for everything you do. It helps you get published, win grants, and get hired. What is your single best tip for a memorable scientific presentation? hashtag#ScienceCommunication hashtag#PhDLife hashtag#Postdoc hashtag#PublicSpeaking hashtag#AcademicChatter hashtag#Leadership

@GarryPNolan Listening the episode it as I saw this come up in my notifications list 😁

I had a great conversation with Joe on the "Joe Rogan Experience" this week. First off, Joe is a consummate gentleman, and his staff at the studio were a lot of fun to talk to before and after the show. Second, the art and paraphernalia in the studio, which represent the years of interviews he has given, were like being in a museum of eclecticism. So much cool stuff, with, I am sure, a fascinating story behind each. We talked about my lab's work in cancer research at the immune-tumor interface, AI applications in cancer (and the direction of AI in general), and then the scientific way to approach the "reality" or not of fringe topics (reclaiming the work), such as non-human intelligence (AI amongst them). It was a discussion centered on ideas —not conclusions. And how science should be done in frontier realms. Thank you, Joe, for the opportunity! It was a joy from beginning to end. open.spotify.com/episode/5rCPRn… youtube.com/watch?v=B7y3qc…

Wordle 1,509 5/6 ⬛🟨⬛⬛⬛ 🟩🟩🟩⬛⬛ 🟩🟩🟩⬛⬛ 🟩🟩🟩⬛⬛ 🟩🟩🟩🟩🟩

These situations are so frustrating!!! A legitimate multi-year study with substantial funding for a project looking at recovering hearing loss was terminated because the PI/grant is part of an ‘increasing workforce diversity’ initiative. How is this not covert discrimination?

Apply today and be part of inspiring science! Deadline July 23rd! #Proteomics #Postdocs

Check out the News and Views from Marina Terekhova and myself discussing the very cool paper explicitly unlinking aging and inflammaging: nature.com/articles/s4358… Here is original paper by Franck et al: nature.com/articles/s4358…

@Crazymoments01 @realDonaldTrump Propagandist

@realDonaldTrump Describe President Trump in one word?

“THE ONE, BIG, BEAUTIFUL BILL” has PASSED the House of Representatives! This is arguably the most significant piece of Legislation that will ever be signed in the History of our Country! The Bill includes MASSIVE Tax CUTS, No Tax on Tips, No Tax on Overtime, Tax Deductions when you purchase an American Made Vehicle, along with strong Border Security measures, Pay Raises for our ICE and Border Patrol Agents, Funding for the Golden Dome, “TRUMP Savings Accounts” for newborn babies, and much more! Great job by Speaker Mike Johnson, and the House Leadership, and thank you to every Republican who voted YES on this Historic Bill! Now, it’s time for our friends in the United States Senate to get to work, and send this Bill to my desk AS SOON AS POSSIBLE! There is no time to waste. The Democrats have lost control of themselves, and are aimlessly wandering around, showing no confidence, grit, or determination. They have forgotten their landslide loss in the Presidential Election, and are warped in the past, hoping someday to revive Open Borders for the World’s criminals to be able to pour into our Country, men to be able to play in women’s sports, and transgender for everybody. They don’t realize that these things, and so many more like them, will NEVER AGAIN happen!

@LeNaeGoolsby @BernieSanders Not all of them are elitists. And its policies help allow that that are being targeted.

@BernieSanders Cry me a river—Harvard & Columbia elitists ‘cave’? Trump’s DEI cuts skip them (NYT, Apr 5). Respect’s just fine; they’re teaching grit, not groveling. Souls? Elitists don’t have ‘em

The function of higher education is the pursuit of truth. Universities like Harvard & Columbia aren’t only losing their souls when they cave to an authoritarian president — they are sacrificing the international respect they’ve earned & teaching their students a very bad lesson.

So we’re essentially cutting funding for research and medicines that could help in a relatively short term to those in need for the potential for longer survival primarily benefiting the elite? @elonmusk

It appears that US Space Force isn't taking a DOGE like cut as the other agencies are. On Friday it announced three big contracts. The biggest: $6 billion to Elon Musk's SpaceX spaceforce.mil/News/Article-D…

Dear scientists, physician scientists, post-doctoral fellows, technical staff, etc, this time in history is not business as usual! We need to stop posting our paper was published in journal X without telling the American people how our work will help them & our society!

I get a lot of questions on the #NIH #K99 #postdoc to faculty transition award. Decided to pen my thoughts and experiences towards receiving the K99/R00 - hoping it would be helpful for the community. Please find article link at - debosardarlab.org/blog

Postdoctoral position available in my group at @Stanford to study #environmental influences on the human #epigenome we have several projects looking at chemical, climate change and social exposures. #postdoc #PhDchat #AcademicTwitter #epigenetics med.stanford.edu/cardenas-lab/t…

Consider joining our growing comp bio team in the Olayan Center for Cancer Vaccines @MSKCancerCenter!

The whole notion of "Write, Read, Edit" as some great driver of progress in biology is incredibly misguided. Yes, DNA sequencing and synthesis costs have fallen rapidly. What have we gotten for it? The vast majority of strains we make don't work, because we don't understand the underlying biology. Scale is still a major issue, too. And just as the Human Genome Project failed to live up to its grandiose expectations, the same is true of many claims made today about cheap genome sequencing. Tools to study and manipulate DNA are one small part of the path toward biological superabundance. DNA is not some master blueprint of the cell, and controlling that DNA will not solve all cellular problems. We also need tools to delicately control protein complexes, intercellular signaling, cellular delivery, and more systems-level operations. And then there are the training issues. It's still way too difficult for students to enter biotechnology as a career. Very few undergraduate programs have curriculums for biotechnology (in the U.S.) Companies still gatekeep people who don't have a Ph.D. The timelines here are way too long. Better tools to read, write, and edit DNA will not lead to biological superabundance. DNA sequencing is absurdly cheap already (fractions of a penny for 1 million bases). So is DNA synthesis. These don't seem like the relevant bottlenecks to be talking about, and yet I hear it all the time in essays, podcasts, and so on. If we want to actually accelerate progress in biotechnology, then we need to understand the cell, build models to drastically shrink engineering timelines, and solve the training bottlenecks. That is the route to a $20 trillion+ bioeconomy.