Chousterman Benjamin

🧬 Un Australien sans formation en biologie a séquencé l’ADN tumoral de sa chienne condamnée, utilisé ChatGPT et AlphaFold pour identifier des cibles thérapeutiques, et conçu un vaccin ARNm personnalisé depuis son salon. Résultat : la tumeur a diminué de moitié. Rosie est vivante !! FAN-TAS-TIQUE. Je me demande ce que diraient Jenner, Pasteur ou les époux Weissman & Karikó en voyant ça - des décennies de recherche institutionnelle distillées en quelques semaines par un type armé d’un chatbot et de 3 000 dollars. L’IA transforme n’importe quel humain motivé en scientifique. On va guérir tellement de maladies !! 🧬

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Quelle tristesse

Sur instructions du ministre de l’Intérieur, @NunezLaurent, et sous l’autorité du @prefetpolice, un dispositif de sécurité renforcé est déployé autour des lieux de culte juifs et des rassemblements organisés à l’occasion des célébrations de #Hanouka.

Finally online

This was so much fun to write, thank you @SwirskiLab and @FGinhoux !! A summary of the many surprising jobs that immune cells do after hours (and it is more than just cleaning up) Immune system influence on physiology | Science science.org/doi/10.1126/sc…

Which trials registries are acceptable to the icmje.org ? anzctr.org.au AUSTRALIA-NZ clinicaltrials.gov US ISRCTN.org UK umin.ac.jp/ctr/index/htm JAPAN onderzoekmetmensen.nl/en NETHERLANDS eudract.ema.europa.eu EU 1/2

People will tell you CO monitors are at least good for trending (I’ve said the same) What this review supposes is

New 📝 lead by 🌟 fellow @LamarcheRaquel, relevant to anyone who uses minimally/non-invasive CO monitors in patients with septic shock. Open access at @Crit_Care 🎤 drop in the conclusion paragraph!

Benchmarking single-cell multi-modal data integrations👍 nature.com/articles/s4159…

A clinical road map for single-cell omics🫶 cell.com/cell/abstract/…

IVC assessments were the "hot new thing" in POCUS when I was a fellow. Today, it's a minimal component of my practice. There are too many variables involved to help one make a volume status decision based solely on this. 🎩 tip to the authors. eddyjoemd.com/foamed

Assessing shock without pocus is, imo, inadequate.

How do ICU survivors experience their quality of life, beyond functional outcomes, 2 years later? ➡️ Read the original research from Critical Care Medicine: ow.ly/Mc5R50WjmGu #OpenAccess #SCCM #CritCareMed @SCCM

We are rebuilding 💪 nature.com/articles/d4158…

How accurate is point-of-care ultrasound (POCUS) in patients with shock? Very accurate! Our meta-analysis shows point-of-care ultrasound (POCUS) boasts high sensitivity & specificity all shock subtypes as well as the underlying etiology! link.springer.com/article/10.100…

The FUTURE is NOW! 🚨 Whole-Transcriptome Spatial Genomics with OUT-OF-THE-BOX analysis starring @helucro. 🔬 Spatial genomics has now reached FULL-transcriptome resolution, enabling spatially resolved single-cell analysis at million cell scale. With this, we’re rethinking how single cells connect across spatial hierarchies — from, cells to local niches and whole-tissue architecture. 🧬 We combined #CosMx SMI® (@brukerspatial), snPATHO-seq, and digital histopathology across matched human CRC samples (normal tissue, polyps, tumor, lymph node mets) — a unique setup enabling single-cell spatial trajectory reconstruction of epithelial transformation. 📍 Our study bridges classical histopathology and single-cell omics, powered by transcriptome-wide imaging of ~3.5 million cells. This allowed us to map the evolving cellular ecosystem and structural remodeling during colorectal cancer (CRC) initiation and progression. 💡 Highlight: - Defined rare ‘transition crypts’, shedding light on localized transformation. - Identified distinct epithelial transformation paths (🔹LGR5⁺ stem-like cells in tumor cores AND 🔹MMP7⁺ fetal-like cells at invasive fronts). - Discovered concentric tumor microenvironments aligning with malignancy grades. - Traced MMP7⁺ tumor cells and FAP⁺ CAFs to invasion sites and metastases. A shout out to the @cnag_eu Spatial Team led by Pascual Pascual AND our fantastic collaborators at @bruker led by @joebeechem AND the KU Leuven team led by Sabine Tejpar. 📢 NOW out @BioRxiv! Check out the Preprint here: biorxiv.org/content/10.110…

In a pilot RCT with 45 ICU patients with severe brain injuries and MV>48h, recorded family voices supporting weaning trials ("breath in and out", "you can do it") vs sham led to reduced weaning time. academic.oup.com/braincomms/art…

3 weeks into the new editorial board for JACC BTS, the JACC family member for basic and translational discoveries! Please consider JACC BTS for your manuscripts. We do fast, friendly and fair peer review. Because life is short and science is fast ⚡️❤️‍🔥🧠

12 interviews (1 minute each) 12 major trial presented few days ago in Belfast @CritCareReviews @RobMacSweeney1 linkedin.com/company/critic… what did you do? what did you find? what does it mean?