Biton Lab

Read the full story here: nature.com/articles/s4159… @NatImmunol Shout-out to the great team and our amazing collaborators who worked on this project over the years @SachaLEBON @bitonm @matanhofree 10/10

Beyond infection, this raises an important possibility: ISC inflammasome activation may shape epithelial remodeling in chronic inflammatory and neoplastic contexts, including IBD and colorectal cancer. 9/

🧵 It’s out 📑 What happens when Salmonella reaches the intestinal crypt, not just the surface epithelium, but the specialized cells that maintain and defend the tissue? Our paper follows bacterial invasion at single-cell resolution nature.com/articles/s4159… @NatImmunol 1/

Our findings uncover a mechanism by which adult stem cells integrate environmental signals to maintain tissue homeostasis. Congrats to @Aviya_HM and the whole Biton lab team!🎉🎉🎉

Excited to share our new @biorxivpreprint from the lab! We show that intestinal Lgr5⁺ stem cells are active luminal sensors that use apical TLR2 signaling to detect microbiota-derived cues and regulate epithelial differentiation and antimicrobial defense. biorxiv.org/content/10.648…

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens. doi.org/10.64898/2026.…

Excited to share our latest preprint with @Sagi_Lab on @biorxivpreprint! The ECM remembers inflammation—forming a scarred niche that reprograms stem cells and drives chronic disease. The ECM isn't passive—it instructs. 🔗biorxiv.org/content/10.110… #IBD #ECM #StemCells #Inflammation

Join us at #IUIS2025 in Vienna, Austria for an exciting plenary on Innate Immunity and Inflammation with speakers, Dr. Miriam Merad (@MiriamMerad, IUIS President) and Dr. Caetano Reis e Sousa (@ReiseSousaLab)! Learn more and register at iuis2025.org!

Happening TOMORROW! Don't miss #IUIS2023 Rising Star Dr. Moshe Biton (@bitonm)'s talk on "Elucidating intestinal stem cell innate immune properties" on Fri, 1 Dec, 10:00 - 10:15 SAST in Auditorium I. Check out this clip to learn more about his research program!

"In the face of darkness, let our voices be the guiding light". A clear message from the @WeizmannScience to our fellow scientists and friends. Thanks for being there for us, we will never forget 🙏📷 #StrongerTogether.

Excited to host Prof. Xavier w/ @BINAWIS1 ! His captivating lecture on Controllers of Barrier Defense and translational clinical research left us all feeling inspired and motivated. Amazing talk ! Thank you for sharing your expertise with us, Prof. Xavier ! @TheXavierLab

Very exciting h trip at #ILANIT2023 conference! Our team rocked the stage with talks from @bitonm, Vlad, and @SachaLEBON, while Carmel and @Aviya_HM wowed us with their poster presentations. So proud to be part of such a talented and innovative group! 🤩🎉👩‍🔬👨‍🔬📊📈

Can't end 2022 without some pictures from our IRB departmental retreat, right?