Bo Anderson

@beastiewifhat @rn_flex Not AI, but I guess I'll work on writing better if it sounded like it. Thanks for the feedback

@boanderson @rn_flex ai slop

Sept 23 2023. That's when I took my first dose of retatrutide. Nearly 1000 days ago. I had no idea how much it would change my life that day. I'm now 30% lighter. My asthma & fatty liver disease are long gone. My chronic achilles tendonitis disappeared 3 months into the trial.

@getfitwjessic Stop guessing and start knowing is exactly it. "Fine" on paper while feeling off is the whole reason to track your panels over time, not just read them once.

Stop guessing & start knowing! Sure "bloodwork" comes back "fine" and yet you still feel OFF, so is it really fine? As someone who's lost a 180lbs and has dealt with PCOS & low testosterone levels I highly recommend knowing your panels If you don't...

@PeptideJourney Smart to confirm it with bloodwork first instead of guessing. Now that it's in the stack, keep the labs and how you feel on the same timeline. The next pull will tell you what that addition actually did.

Comprehensive bloodwork completed confirms I’m extremely low testosterone so I’ve adding that to my stack of peptides. I’ve done more to improve my health without a doctor than any of my docs have done in decades!

@chancedite The labs telling a different story than the mirror is so common. Low melatonin, congested liver, low T, none of it shows up until you test and then track it over time. Getting it all in one place is exactly why I'm building @getjoust. Glad you caught yours.

A few years ago I looked like the answer to the question people were asking. High output. Built physique. Running a water company. Externally crushing all areas of life. The labs told a different story. Leaky gut Low melatonin Congested liver Low testosterone Woman level estrogens Stage three Adrenal fatigue A biological foundation quietly coming apart beneath a surface that looked completely intact. The gap between what was visible and what was measurable was the thing that changed everything. Not because the gap was embarrassing. Because it was instructive. The highest-performing version of the body I had built was still operating on a compromised foundation. Function had adapted around the dysfunction so well that the dysfunction was invisible, even to me. That is the most dangerous version of the problem. Not the kind you can feel. The kind that looks exactly like health while the foundation erodes. The labs do not care how you look. They report what is actually happening. That is why they exist.

@drjaminb Appreciate a doc saying this. Full workup first, then track symptoms over time before reaching for a script. A lot of what looks like low T moves with sleep and stress. Baseline plus a clear timeline beats a one-time number.

Low testosterone is real. But it's also massively over-diagnosed. If someone is trying to sell you T without a full workup — bloodwork, symptoms assessment, ruling out other causes — get a second opinion.

@MrAcezzz Good point. In range but still soft, foggy, low drive happens a lot, and it lives in how you feel day to day, which never shows on a single panel. Tracking symptoms next to the labs is the only way I've found to catch it.

Your testosterone can be fine and u can still be estrogenic. Nobody talks about the liver. congested liver means poor hormone clearance. Estrogen recirculates. Builds up. Your bloodwork looks decent and ur still soft, foggy, low drive. Kefir daily. Bile flow. Real food. Let the liver do its job. The problem was never production, it was clearance.

@drmarlonperalta Good framing. The two paths usually look different in the data, energy, sleep, and training, not just the scale. Watch only the weight and you can't tell if you're building the engine or just under-eating.

Use reta to eat like a toddler for 6+ months, feel like shit, then blame it on the drug. OR Use retatrutide to build an engine that processes massive amounts of food to give you unlimited energy

@mannyjplays Subtle but noticeable is the hardest kind to judge. That's where logging it daily next to sleep and resting HR pays off. A few weeks in, the subtle stuff usually shows up as a real trend instead of a maybe. Curious how it reads for you over a full cycle.

🧪 Time for my daily 1mg SS-31 dose 🧪 My sweet wife organized our syringes and alcohol wipes in this handy basket ❤️ My experience with SS-31 so far has been subtle but noticeable. SS-31 is a mitochondria-targeting peptide designed to help support cellular energy production by binding and repairing cardiolipin, a key lipid found in the inner mitochondrial membrane that regulates the electron transport chain. By supporting mitochondrial function, it may help cells produce energy more efficiently and reduce oxidative stress. I’m about halfway through my 30-day protocol before I anxiously jump into MOTS-c. During the first week or two, I actually felt more fatigued and weaker in the gym than before starting. However, over the past week, my strength has started climbing back up and my running pace has improved. My personal theory is that the initial fatigue may have been related to underlying cellular and mitochondrial repair processes that were temporarily demanding additional energy. Overall, I’m glad I’ve experimented with SS-31 and I’m looking forward to running another cycle at a higher dose in the future. 🏃‍♂️💪🔬 As always, this is just my personal experience and not medical advice 🏥 If you’re interested in trying SS-31 for yourself or looking to restock your supply, check out GlacierAminos.shop 🧪 They offer competitive pricing, thorough 7x testing, and fast shipping. They’re also running a sitewide 15% off sale this weekend, and you can stack an additional 10% off with code MANNY 💰 Happy researching! 🔬

@bourboli This is the way. Labs only mean something when you line them up against what changed in the protocol. Slightly skewed but still optimal, A1C improved, tolerating it well...that's a clear read because you've got the last pull to compare to. Nice work

This weeks labs came back. Values I checked were all very slightly skewed from last labs as expected with current protocol vs trt only last time. Still in the very good-optimal range for me. A1C was improved. So looks like I can tolerate current protocol well. Health phase soon.

@MeadowRainRun This is a great log. Sleep fine under 100mg caffeine, energy up, anxiety slightly up. That's exactly the stuff that's easy to forget by next month. I keep notes like that on the same timeline as the dose so the pattern shows up when I titrate again.

Titrated up from half a mg of retatrutide to 1 mg after 4 weeks. Appetite suppression is real now Sleep is fine as long as caffeine kept to 100 mg or less Energy is crazy. Walking lots to keep up. Anxiety slightly up

@Lee_Maasen Agreed. And outcomes aren't just the scale. Sleep, resting HR, and HRV tell you what the protocol is doing to your body, not just your weight. Hardest part is getting it all in one place so the data actually means something.

Excuses don't change results. If your peptide protocol isn't working, it's not because you're busy or stressed, the compound doesn't care. You either get results or you don't. Data over feelings, every time. Stop searching for reasons, start tracking outcomes.

@_9th_Life_ Enclomiphene as the on-ramp makes sense, lower commitment than jumping straight to TRT. The people who do well with it seem to be the ones actually tracking their labs and how they feel, not winging the dose. Good read on where this is heading.

Most people I know irl are still on the fence about peptides, but the overall vibe on optimization is quickly evolving... One thing I am seeing commonly among the general fitness population is enclomiphene as a jumping off point into hormone optimization I have also noticed when most guys actually go do their bloodwork and see their test in the lower range, they become way more interest in TRT The curiosity around peptides is at an all-time high. - GLP1s, Lots of hype around Reta specifically. But in the non-fitness space, I am seeing a ton of attraction towards Tirz. Especially on the female side of things. - BPC157/Wolverine stack is probably #2 on peptides. Once people starting using a GLP1 (and learn more about peptides in general), get results from weight loss, the question becomes "what else can peptides do for me?" and in many cases people have a bad shoulder/knee they are willing to experiment on. - GHKCu is getting really popular across the board, probably due to the looksmaxxing movement, but this one seems less gender specifc. Both guys and gals alike are taking notice. - MOTS-C seems to be picking up some steam as well in the biohacking/longevity/fitness space, the results from this one in particular are felt immediately so the hype is growing. - HGH/GH secretagogues seem to be more fitness/bodybuilding adjacent. But I predict this will change. I can feel the momentum building here. This isn't just a niche bodybuilding/biohacking thing anymore. It's cross pollinating across many different populations.

@olavson75543 Sleeping better on the lower dose is interesting. I'd want that on the same timeline as the switching schedule, just to confirm it holds over a few months. Are you seeing it in your actual sleep data or more in how you feel?

I've observed that switching between Tirzapetide and Retatrutide every other week seems to reduce tolerance, thus keeping a low dose and sleeping better.

@iliveulongtime Smart getting the baseline first. Most people skip it and then can't tell what actually moved. I keep labs on the same timeline as the protocol so the next pull tells a clear story. Following to see where that number goes.

Got my bloodwork before starting peptides. Total T came back at 487 — "in range" according to the lab but that's average for a 50 year old, not a 34 year old. Running enclomiphene 12.5mg daily + kisspeptin 500mcg every other day. Enclomiphene blocks the estrogen brake on testosterone production. Kisspeptin stimulates GnRH at the top of the chain. Two different mechanisms, both pushing natural production — no TRT, no shutdown, no dependency. Targeting 700-800+ in 8-12 weeks. Retesting to confirm. Full fertility preserved.

@a7las1984 Wild how everyone runs a different dose and gets a totally different number back. That's why I keep my dose and my labs side by side. Your own response gets obvious instead of comparing to someone else's units.

Sister and brother in-law were over and we got to discussing TRT. We're both on TRT. My sister is a nurse and shares his blood work with me as they were surprised I am taking 200mg per week (puts me at 930 Total and 160ish free) I asked his dose and he said he takes 20 units 2x per week, of course he didn't know the mg 🤦‍♂️ I assume it's 80mg per week. Either way, whatever the dose, it puts him at 358 Total T doc didn't even order Free T 🤦‍♂️ Doctor was happy with 358 because it's "in range" He said his doctor was worried because his hematocrit was high. Checked his bloodwork and it showed 51... 51 isn't high in a TRT context. What are we doing guys? I've been on TRT for 1 year and know this is wrong... My advice was to: - Talk to his Doctor about increasing his dose - Increase the frequency of injections - Improve hydration

@BadTechBandit A 65 to 80 resting HR jump is the kind of thing you only catch when sleep and RHR sit on the same timeline as your doses. This type of analysis is why I'm building @getjoust. Curious what the Ipamorelin does to your HRV over the next few weeks.

Been on reta cycle for 3 month (lost 25 pounds doing maintenance dose at around 2 MG a week) As expected my resting heart rate (RHR) jumped from around 65 bpm closer to 80 bpm and stayed there. Last week I started on Ipamorelin before bed And I've noticed a pretty major change in my RHR, it's back down into the 60s again... has anyone else noticed this when adding GHRP (Growth Hormone Releasing Peptides) while on Retatrutide? Wondering if growth hormone secretagogues with Reta is the way to fight elevated heart rate side effect 🤔

@ElevateBiohack Bromantane's a fun one. With cognitive stacks I wish people tracked the boring stuff alongside it - sleep, HRV, etc. The on/off cycling makes it so easy to fool yourself about what's actually working.

Amazed that in 2026 people are still sleeping on Bromantane + TAK-653. I’ve been running this stack on and off for so long now, (often with a bit of flmodafinil) and it’s been outstanding. Clean motivation that actually lasts, laser focus without the wired feeling or afternoon crash, and a real sense of drive that sticks even on tough days. Here’s why it hits different in my opinion, bromantane ramps up your body’s own dopamine production by boosting tyrosine hydroxylase and dopamine synthesis in the brain. It’s not just flooding receptors like a typical stim, it helps your system make more naturally while also acting as a solid adaptogen for stress and fatigue. TAK-653 then layers on strong AMPA receptor modulation. It fine-tunes glutamatergic signaling to sharpen cognition, speed up learning, and support actual neuroplasticity without the overstimulation you get from racetams or heavy stimulants. Together they create this balanced dopamine-glutamate synergy that feels like optimized mental performance instead of forced stimulation. Motivation, focus, and resilience all improve in a way that compounds over weeks. If you’re already deep into nootropics or peptides and haven’t researched this combo yet, you’re missing out. Educational/RUO only. Get bloodwork, respect your baseline, and lock in fundamentals first. Questions or protocol notes? Drop them below or DM. Use code ELEVATE with trusted research vendors like Kimera Chems. Level up your mind. #ElevateBiohacking #RUO #Bromantane #TAK653

@ogsvg "Research use only… but here's a human dosing guide" is the whole gray area. That's why your own data matters most tracking your dose next to your actual vitals + sleep. If you're going to "research" then it should be backed by data.

Another thing I cannot wrap my head around are RUO vendors that publish blogs on their site about the different use cases in humans about peptides they’re selling. Studies, articles, etc about the different benefits of peptides. 🤦‍♂️ From a risk/reward perspective you’re killing your entire defense of being RUO by implying human use with articles you’re posting on your own site. What’s the upside? Maybe a few conversions??? reptides is different because we aren’t affiliated with anyone nor do we sell peptides. we’re just writing about the market editorially and surfacing literature and evidence. When all of this is said and done the FDA, DEA, and whatever regulatory bodies get dragged into this are going to have a field day…

@ThePepGuy Solid five. BPC-157 + TB-500 is the combo I get asked about most. How are you tracking response - sleep, HRV, recovery - and not just "feel"? The recovery peptides are the easiest to fool yourself on. Selank's the sleeper here.

My Top 5 Peptides (no particular order) BPC-157 🩹 TB-500 (TB-4) ⛑️ Tesamorelin 💪🏼 NAD+ ⚡️ Selank 😎 Honorable mentions: Semax 🧠 GHK-Cu 💙 Didnt realize how difficult it would be to choose only 5! 🤣 How we feeling about this? Whats your top 5? Drop em below 👇 - ThePepGuy🔋