Brown Lab

I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo. A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models. #Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158… a 🧵

Immunoschool opens next week to explore why how well we age is shaped in large part by our immune system and is 🌍, online, FREE & open to all. Don’t miss hearing from the scientists who built the immune aging field & those pushing it forward: REGISTER: eventbrite.com/e/internationa…

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth dlvr.it/TRQrLV

2. Although most work and attention has been on engineering T cells, macrophages are the most abundant immune cells in tumors and many strategies are now emerging to target these cells Reviewed here sciencedirect.com/science/articl…

Online Now: Macrophages: Targets for next-generation cancer immunotherapy dlvr.it/TRB5tg

Our new Nature study, lead by @yuexing identifies a brief early-life window when skin dendritic cells sense common allergens and trigger inflammation right in the skin without migrating to lymph nodes. We define this in-situ activation state as peripheral immune inducer (pii)DC, and show it emerges because of a still-maturing HPA axis and low systemic glucocorticoids. #Naiklab 👉Key takeaways: 1. Early-life immunity plays by different rules. During this window, innate responses to allergens in skin are heighted. 2. Hormones shape immunity in real time. Developmental neuroendocrine states profoundly tune how the immune system reacts, and can set the stage for inflammatory disease. Thanks our incredible collaborators @niroanandalab @EmmaGuttman @kamalkhanna @Teresalu @Amandalund and others. Our funders @NIAIDNews @NIH @DermalCell @SinaiImmunol @MSHSDerm nature.com/articles/s4158…

We're pleased to share this review on current & future macrophage-targeted therapies as a central pillar of next-generation immunotherapy. Written with the fantastic @MatthewD_Park, Brian Brown & Kevin Sun. doi.org/10.1016/j.ccel…

Online Now: Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth dlvr.it/TQX1z9

Out now @Cancer_Cell: armored macrophage-directed anti-TREM2 CAR T cells for solid tumors. Grateful to contribute as co-first & co-corresponding author, alongside back-to-back work from @Brown_lab1 & @MiriamMerad, highlighting the rising momentum of macrophage-targeted therapies.

What if we could turn the tumor’s deadliest tricks against it? New @Cancer_Cell: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Led by @GalYagel, @D_Rimini & @MVLocquenghien (1/15) cell.com/cancer-cell/ab…

We’re very close, and when we reach 2000 signatures, petition will be sent to @GovKathyHochul ahead of her Executive Budget announcement and revision period throughout January! So share with friends & family! c.org/hwy54dWJDb

📣 VIRTUAL TOWNHALL 📣 This Friday. Organized by NY-CURES & postdoc unions ✍️ >>> docs.google.com/forms/d/e/1FAI… Find out how the proposed Empire Biomedical Research Institute can help solve issues NY State is grappling with: affordability, workforce stability and long-term health & economic growth.

New York’s research ecosystem delivered plenty of “nice list” rewards this year. Now we need Albany to deliver EBRI so we can keep that impact growing. Research is the gift that keeps on giving, so for a healthier and wealthier New Year for all New Yorkers, sign our letter to 🎅 >>> c.org/hwy54dWJDb

New York’s own Emerging Technology Advisory Board just released a major report—and its recommendations directly align with the EBRI proposal. If we want NY to lead in biotech, research, jobs, and innovation, this is the moment to show we share their vision and sign the petition >>> c.org/nDnRNSsVcq Dive deeper and read the full Emerging Technology Advisory Board report here: michaeljfox.org/sites/default/… and the “preprint” of the EBRI proposal here: amsny.org/advocacy/state… Both lay out a strong, evidence-driven roadmap for how New York can lead in biomedicine for decades to come. And this is just the beginning. Once the EBRI concept is included for consideration in the FY27 budget, the proposal will be expanded into a comprehensive statewide plan. For opportunities to help shape what is included during the “revise and resubmit” phase, join the NY-CURES coalition > nycures.org

Need more info before signing petition for state-backed research institute? Get the full behind-the-scenes story by @DrShrutiNaik of how the Empire Biomedical Research Institute proposal came to be, what’s needed to move it forward, and how other states can follow suit: keypoint.keystonesymposia.org/home/shruti-na…

Fantastic new 🗞️ in @Gothamist from @clewisreports... Our extra 2 cents for free! The Empire Biomedical Research Institute doesn’t compete with other urgent needs — it equips NYS to meet them. Not funding EBRI now worsens economic pressures; funding it will grow the economy to help fix them over the longer term. The economic impact of biomedical research in NYS can fuel free 🚍 and more @ZohranKMamdani ! gothamist.com/news/ny-medica…

What drives our push for a state-wide funding institute is the recognition that everyone in the biomedical research ecosystem — from students to PIs, critical support staff, and the patients who participate in trials & advocacy — are rock stars. ✍️ & share the petition, lets get to 700 signs tomorrow! c.org/nDnRNSsVcq

Wondering why you should ✍ our petition? In @ImmunologyAAI, founder @DrShrutiNaik reveals why the coalition was formed, why NY needs a state-backed research institute, and how scientists should organize for systemic support — here and nationwide. 🧐 news.aai.org/2025/11/20/ny-…

We’re in a proud, confident and ambitious Empire State of mind! If you believe in building a better and brighter tomorrow, hustle on over to sign and share the petition for an Empire Biomedical Research Institute to fuel the future and the people like you who power discovery 🔗 c.org/hwy54dWJDb

Fabulous comment on the need for a state-wide biomedical research funding institute in New York! Sign & share the petition calling for this - if you live in New York State or nearby - as well as new therapeutics, the economic benefits also spillover! c.org/nDnRNSsVcq