Alex Böcker

My lab is starting at UW-Madison! This is a unique opportunity to contribute to impactful computational neuropathology research in a collaborative environment. Join the Nirschl Lab and help drive discoveries that improve our understanding of neurodegenerative disorders!🧠

Excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons" Now on BioRxiv! biorxiv.org/content/10.110…

Congratulations to Erika Holzbaur for securing a $1,000,000 donation to establish a Huntington’s Disease Research Fund. The donation will be used to support Huntington’s research by three postdoctoral fellows for three years in key University laboratories.

So proud of this beautiful new work from Dan Dou, and so grateful to Virginia Lee for inspiring this study!

Dou, Aiken & @ErikaHolzbaur @PennMedicine show that #Parkinsons disease-associated hyperactive LRRK2 decreases the trafficking of synaptic vesicle proteins within neurons by disrupting the regulation of the synaptic vesicle precursor protein RAB3A. hubs.la/Q02qgtts0

@019_escape Hi Mukaram! Just double-checked and the link seems to be working. Try here: boecker-lab.uni-goettingen.de/wp-content/upl…

📢 Fully funded PhD position available in my lab in Goettingen, Germany If you are interested in cell biology and the pathophysiology of neurodegenerative diseases, we'd love to hear from you! 📅 Application Deadline: Feb 9th 2024 For more details visit boecker-lab.uni-goettingen.de/wp-content/upl…

@Aamirsohailkt Yes, of course!

@caboecker Hello Alex is it open for international students too?

Excited that our paper reporting discovery of TMEM55B, a new downstream lysosomal component of the LRRK2 #Parkinsons pathway, has been published. Congrats @Prosen21, @MattTaylor_69, Yuko Lam, & our fantastic @ASAP_Research collaborators @pfeffersuzanne lab ppu.mrc.ac.uk/news/parkinson…

My last paper from grad school is in press! Please check it out--thanks to good suggestions from reviewers and a lot more work, it has a significantly more detail than the BioRxiv version @ErikaHolzbaur @JCellBiol doi.org/10.1083/jcb.20…

What regulates the transport of autophagosomes along the axon? @sydneycason & @ErikaHolzbaur show that mature axonal autophagosomes are transported by the #microtubule motor #dynein, activated by JIP3/4, & regulated by ARF6 & RAB10 bit.ly/3MrP5Nw #Neuroscience #autophagy

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors biorxiv.org/content/10.110…

📣Take away: OPTN does it differently! 🚨Thrilled to share my latest #notacover piece prepared for @ThanhNguyen_TNN @LazarouLab @martens_sascha @mito911_ on #unconventional #OPTN-mediated #PINK1/#Parkin #mitophagy! sciencedirect.com/science/articl…

@AlvFdezFdez_PhD @DanDou52257793 @ErikaHolzbaur @yourUMG Thanks!

@caboecker @DanDou52257793 @ErikaHolzbaur @yourUMG Congratulations to you all! 👏

Very happy to share our latest work on LRRK2 (and my first paper as co-last author). We find that LRRK2 mutations disrupt a regulatory balance between LRRK2, PPM1H, and ARF6, causing impairment of axonal autophagosome transport. @DanDou52257793 @ErikaHolzbaur @yourUMG

@Luis_BonetPonce @OhioState Congratulations, Luis!!

@purplehaziness @DanDou52257793 @ErikaHolzbaur @yourUMG Thank you, Akshata :-)

@caboecker @DanDou52257793 @ErikaHolzbaur @yourUMG Congratulations @caboecker! Exciting to see your work on this important project.

@TimNFeinstein @aaandmoore @DanDou52257793 @ErikaHolzbaur @yourUMG Thank you!

@caboecker @aaandmoore @DanDou52257793 @ErikaHolzbaur @yourUMG An impactful application of cell traffic with major translational implications. Congrats!

Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes dlvr.it/SnPb92

A threat to all scientists in Germany, particularly to postdocs: On 17 March the German Ministry of Science released a paper on the planned amendment of the German Act on Temporary Scientific Contracts. Contracts for postdocs shall be limited to 3 years - then you are out!.....