Michael Morelli@morellifit
There's a question that keeps coming up: is retatrutide better than tirzepatide?
In my experience, this is the wrong question.
It's like asking whether steak or chicken is better.
Steak is arguably more nutrient-dense, but some people do better on chicken, and there's no reason you wouldn't vary your protein sources.
It's the same with GLPs. It's not either/or, you have to experiment.
> Tirzepatide is a dual agonist. It hits GLP-1 and GIP receptors.
> Retatrutide is a triple agonist. It hits GLP-1, GIP, and glucagon receptors.
That glucagon piece is the key difference. It changes how your body uses fuel in a way tirzepatide simply doesn't.
In clinical trials, retatrutide produced 24% average weight loss in 48 weeks.
Tirzepatide produced 21% in 72 weeks.
Reta produced better results in almost half the time. The glucagon receptor drives thermogenesis and fat oxidation, which you don't get with a dual agonist.
But retatrutide comes with a tradeoff.
It raises resting heart rate by 5-10 BPM, driven by the glucagon receptor, and happens at every dose level. Reta peaks around week 24 and reverses when you stop.
This doesn't happen with tirzepatide.
And that's exactly why you shouldn't be on either of these indefinitely.
The problem is that most people are scared to cycle off because they've heard the horror stories about weight rebound. As a result, they stay on way too long.
This isn't medical advice, but I believe the right approach is to be 12-16 weeks on, 8-10 weeks off. You cycle, monitor, and adjust.
If you don't know how to properly come off a GLP, you have no business being on one.
On top of that, if you're running the experiment but not tracking it, you're wasting it.
- Get labs done: fasting insulin, blood glucose, A1C, etc.
- Wear a tracker: monitor heart rate and HRV
These compounds impact metabolic markers that matter way more than bodyweight.
If you have weight to lose and you're interested in GLPs, run at least one cycle of each.
See how your body responds to retatrutide.
Then see how it responds to tirzepatide.
Compare the data, and that's how you'll find what works.
Because in performance healthcare, data wins, not the math.
Comment "FATLOSS" below, and I'll send you my 70-page Peptide Bible.
P.S.
None of this is medical advice nor a recommendation.