CogniPharm: Decoding Aging

Video introduction to Epigenetic Reprogramming.

I think the only way this timeline can be achieved is if we get lucky with partial reprogramming and it turns out to be all that's needed to reverse aging. It is possible that Altos or a similar research group will soon find a way to do reliable and safe partial reprogramming. Still, there is more than a 50% chance that it won't be enough. We need to invest in fundamental aging research to first understand all its mechanisms - after that, it will be an engineering problem to solve.

@PeterDiamandis Nonsense. LEV is absolutely a reasonable concept & I believe inevitable, but it's not at all on a predictable engineering timeframe or even close. Predicting 2032-2033 isn't based on any reasonable data. I'd be happy to watch you try to justify your estimate.

Longevity Escape Velocity (LEV) isn't science fiction anymore. It's on an engineering timeline... When we start adding 1 year+ of healthy life per year circa 2032-2033, everything changes. Race is on. LFG!

I hope you are right, but before longevity becomes an engineering problem, we need to understand what aging actually is. The work on epigenetic reprogramming is more of an educated guess than a certainty. It may well work, but we might also discover that it is not the whole story. The truth is, no one knows for sure until all mechanisms of aging have been researched.

@davidasinclair The main scientific argument against aging reversal is that aging exists because it benefits natural selection. However, our technological development allows us to adapt to changing environments far faster than natural selection, defeating this argument.

New paper addresses arguments against aging research, namely: 1. Aging’s "naturalness" 2. Concerns about resources 3. Stagnation of society 4. Worries about meaning & boredom Authors show that none are logical sciencedirect.com/science/articl…

It's interesting, but a 9-15% life extension in C. elegans isn't significant. For perspective, dampening the insulin signalling pathway in worms can easily double or more their lifespan and healthspan, as well as in fruit flies. However, if they can replicate this result in larger animals, it will be noteworthy.

Very Big News. Elon, this would be a good time to launch LifeX and do for radical longevity and age regression what you’ve done for everything else.

@MaxUnfried Great slogan! 😃

May we live as long as the elves.

@davidasinclair @Dr_Singularity @grok @lifebiosciences It's an interesting question, isn't it? On the one hand, the valuation should be unimaginable. On the other hand, patent protection may be a weak defence, leading to an ugly and scary situation quickly.

@Dr_Singularity @grok what's the valuation of @lifebiosciences if their proprietary age reversal cures blindness next year in humans then works whole body? Approvals in 100+ countries; becomes standard of care; market $5T+ via healthcare disruption; 30-50x $10-50 trillion

Which tech company, in your opinion, is the most undervalued at the moment?

I don't think aging needs to be classified as a disease to address it, but I disagree with some arguments: 1. Ageists will remain ageist; others won't be swayed by a disease label. 2. This argument seems illogical: people are more likely to fight a disease than something seen as inevitable. 3. I can see this happening, with some charlatan "doctors" offering "cures." 4. I agree: big institutional funding will flow when there's a clear solution pathway or full understanding of aging. My main concern with classification is that many will choose to age naturally. We must respect their choice. Labeling aging as a disease could make them feel ill or less worthy, which we should avoid.

Should aging be called a “disease”? A new philosophy paper says NO Here are 4 arguments it may do more harm than good... 🧵 What do you think?

Grab the preprint: doi.org/10.1101/2025.0…. Aging is complex. At Cognipharm, we believe simpler organisms like C. elegans can help us understand it faster. This study is another step towards decoding aging!

Looking ahead, this calls for mapping out similar layers of death causes in animals like mice or even humans. Test treatments in different settings to avoid misreading results, which could improve anti-aging strategies. 7/8

New preprint just dropped on bioRxiv: "A hierarchy of causes of death in senescent C. elegans" from the Gems lab. Ever wonder what really kills aging worms? It's not one simple process - think of it as layers, like an onion. Stick around to see how blocking infections reveals hidden killers like tumors, and what this means for aging theories. 1/8

@davidasinclair @OpenAI @RetroBio_ Yes! I believe the next major breakthrough in longevity will stem from the collaboration of brilliant scientists and AI's power. Excited it's happening! Best of luck to the teams.

⁦Optimizing Yamanaka factors for epigenetic age reversal Congrats @OpenAI⁩ ⁦@RetroBio_⁩ 👏 openai.com/index/accelera…

@bryan_johnson Good one! Happy Birthday!

Today is my bday. If, at some point, I end up dying, you’re all invited to my funeral. I’ll rent out a venue so that you can come and tell me that you told me so. Don’t hold back. Make the most of it. Until then, it’s a pleasure to do life with you all. 💙🫡

@trikcode Hello, a tech guy here too.