Daniel Ryan Howard

Today, I successfully defended my Doctoral Thesis titled, "Understanding how #breastmilk composition alters neonatal #immune trajectory and susceptibility to acute #respiratory tract #infections". 🍾

Online now: Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages dlvr.it/TPmLPM

1/n 🚨 Thrilled to share our new paper out in @ImmunityCP!!! We uncover a surprising, previously unrecognised role for alveolar macrophages (AMs)—long viewed as the lung’s steady sentinels—during allergic type 2 inflammation. 🧵 below 👇 authors.elsevier.com/c/1mFjB3qNrU-i…

Analysis of data from nearly 1.5 million Danish children suggests that infants hospitalized for #RSV infections have a significantly higher risk of developing asthma when one or both parents are also asthmatic. @bart_lambrecht @BosteelsCedric scim.ag/3M1Dbg3

Review: Airway immunometabolic responses during pulmonary bacterial and viral infections @CellReports cell.com/cell-reports/f… @Rutgers_NJMS @RidhimaWadhwa4

Excited to share our new paper in @JExpMed ! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (Trm) amplify antiviral protection during reinfection. 🧵👇1/6 x.com/JExpMed/status…

@QIMRB_Institute @UQ_News @socmucimm @PAQ_qimr

I would also like to thank my examiners Prof. Marcel Nold and Dr. @lisafstinson for their insightful and thorough review of my thesis.

Today, I successfully defended my Doctoral Thesis titled, "Understanding how #breastmilk composition alters neonatal #immune trajectory and susceptibility to acute #respiratory tract #infections". 🍾

Happy to share our latest paper on DC ontogeny! nature.com/articles/s4159… Congratulations to the team and to Dr Zhaoyuan Liu from the Shanghai Institute of Immunology!

Immune development differs between preterm newborns fed mothers’ own m... sciencedirect.com/science/articl…

Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabUCSF and @themis_brown, and our own (now in @Nature nature.com/articles/s4158…), reports that the dietary pTreg program is initiated by RORγt⁺ antigen-presenting cells. /1

Check out our latest work where we built a single cell perturbation atlas of niche cues in inflamed human intestinal organoids. We hope this resource will be of value in generating therapeutic hypotheses to guide diseased epithelium back to homeostasis. biorxiv.org/content/10.110…

Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and @YollandaPariso1 🧵 1/ science.org/doi/10.1126/sc…

A wave of IRF8-dependent Thetis cells impart tolerance to food antigens early in life. Congratulations on the excellent paper! @themis_brown @ScienceMagazine science.org/doi/10.1126/sc…

Excited to share our latest paper! 🎉 A #maternal high-fat diet predisposes to #infant lung disease via increased neutrophil-mediated #IL6 trans-signaling. @CellReports cell.com/cell-reports/f… Congratulations to all involved, particularly @TufaelQIMR and @SimonPhipps14! 🏆

Start of #DC2024 on a beautiful day in Sitges, looking forward to three action packed days of DC biology! dc2024barcelona.com

I’d also like to thank @QIMRB_Institute @UQscience @ASImmunology @Mucosal_ASI @MucosalImmunol for all the support along the way! 🙏

Now off to #DC2024 in Sitges ☀️, Spain, to explore all the fascinating new DC publications, talks and poster sessions! ✈️

Had a wonderful and inspiring three week visit to @themis_brown’s lab at @MSKCancerCenter in NYC learning #scRNAseq analysis of our latest #DC dataset and #TC biology. Many thanks to @socmucimm for the Technique-sharing #grant and @SimonPhipps14 for making the trip possible! 🎉🗽