Dan James

The only way for a true UGA basketball fan to get to their wedding is with @SweaterManSteg

@J_Stensballe @karimbrohi Great thanks!

@danjames36 @karimbrohi I our data from more than 2000 pts, when you as standard of care use TXA acc to CRASH2, most fibrinolysis dissapears and the correlation with mortality is at LY30 > 10 % for TEG. For more see ncbi.nlm.nih.gov/pubmed/2979484…

ITACTIC algorithm for trauma haemorrhage #RCTResultsCommingSoon ⁦@karimbrohi⁩ #isicem19

@PCC_PharmD @EDPharmDRoy @ThePeoplesRuben @ChelseaRames I thought heparinase was used primarily to detect for heparin activity in context of cardiopulmonary bypass and protamine reversal. Have also seen it in studies used to assess adequacy of DVT ppx. Would use non-heparinase for any trauma/ txa study

@EDPharmDRoy @ThePeoplesRuben Is it? I have no idea and cant find any lit on it. The most recent TEG study doesnt mention heparinase in their methods section but the manufacturer lists it as an option to "assess the presence of systemic heparin" which doesnt seem very useful in the trauma bay? @ChelseaRames

Doing a TXA/TEG project with our PGY1 @chelsearames and apparently we run 2 TEG assays. One with a "heparinase" addition to "neutralize endogenously secreted heparin-like substances." As a result, LY30's all seem lower in that sample (which skews more towards shutdown and no TXA)

AMAZING study on TEG data over time among trauma pts and resultant outcomes based on phenotypes. LOTS of data to digest in this one, but HF or SD = bad; persistent SD = bad; HF is either lethal or short lived. No TXA admin'd as data from 2010-2012 #FOAMed bit.ly/2S8HOZ2

@PharmdEMily @ASHP_EMPharm

For prioritizing your day and month divide tasks into these 4 quadrants. #ASHP18 @ASHP_EMPharm

Severely Injured Trauma Patients With Admission Hyperfibrinolysis; Is There A Role Of Tranexemic Acid? Findings From The PROPPR Trial. #TraumaSurg ow.ly/C7dk30lXXhl

Nick Saban on being driven to be the best ⬇️ “There’s an old MLK sermon where he talks about that there’s only “one guy that I let shine my shoes, because of the pride and the performance of how he shined my shoes. I wouldn’t let anyone else shine them.” 💯Be the Best‼️

@topknife “There were no indications made as to the hemodynamic status of the patients enrolled ... Does an abnormal INR matter if a patient is not hemorrhaging and does a normal INR matter if a patient is?” #EASTjc

@topknife How would you address the questions and limitations brought up regarding this study in its “editorial critique”? #EASTjc

#Eastjc is the future of resuscitation Pre-hospital permissive Hypotension with Plasma in the field as well as TXA, if continued bleeding move forward with PCC and MTP continue Whole blood resuscitation ? we have come so far in the last few years!! Exciting time !!!

@topknife “The authors showed an improvement in the time to correction of INR in the 4-factor PCC group to just over 6 hours ... however, patients that die from acute coagulopathy of trauma do so within the first 3 to 6 hours.” #EASTjc

@topknife “Does the correction of INR correlate well with the correction of the coagulopathy of trauma?” #EASTjc

@RVH_Investing It literally says in package insert that it is not indicated for cUTI

$TTPH (STIFEL) We believe intravenous eravacycline is capable of fulfilling an important niche in the treatment of complicated intra-abdominal and urinary tract infections (cIAI and cUTI)

"In education, we often assume that a successful career qualifies someone to teach" Great reminder that subject expertise doesn't necessarily correlate with teaching ability #meded nytimes.com/2018/08/25/opi…

Great talks at #MHSRS2018: @MartinSchreib10 presents multicenter PRCT of prehosp TXA for TBI. Improved survival w 2g dose, and 2/3 of sample met criteria for fibrinolysis shutdown!

No IV access? No problem. New calcium-channel blocker nasal spray effective in converting patients from SVT to sinus rhythm. ow.ly/oVHt30l6aoC #JACC

I spoke with people from the Cubs. The man who grabbed the ball on the widely seen video had actually already helped the little boy get a ball earlier. The young man has a game used ball and a Javy Baez ball. All is well. Guy is A-OK so let it go people.

@Jozefcz1 @BarstoolBigCat 🤤

@BarstoolBigCat Let’s gooooooo @danjames36

OH MY GOD YES

And here’s the man himself. Retweet if you luuuuv puppies!!

Original Article: Recurrent Glioblastoma Treated with Recombinant Poliovirus nej.md/2tDUEPO Editorial: Exploiting Viruses to Treat Diseases nej.md/2lyO8pZ