Davina Biel

Check out our new work where we show that female sex is associated with a stronger Aβ-dependent p-tau secretion, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women @nfranzme @matbrendel embopress.org/doi/full/10.10…

Higher CSF sTREM2 levels were associated with FDG-PET glucose hypermetabolism in early Abeta accumulation but with glucose hypometabolism in late Abeta accumulation.

In participants with early Abeta accumulation, sTREM2 mediated the association between amyloid-PET and CSF p-tau181 increases.

Excited to share our new work in @EmboMolMed🧠🧪 We show that earliest Abeta abnormalities are associated with sTREM2-related microglial responses, which may drive p-tau elevations. Many thanks to @nfranzme, @matbrendel, @M_SuarezCalvet and many others! doi.org/10.15252/emmm.…

Our new paper shows polygenic risk score comprising 85 lead AD-risk SNPs to be associated with enhanced effect of amyloid on the rate of tau PET accumulation, and cognitive decline. Thanks to lead author @AnnaRubinski & @rainermpg, Simon Frerich @nfranzme tinyurl.com/576vd4um

What do fluid p-tau biomarkers reflect? @vermeiren_marie and I provide evidence that p-tau biomarkers are more closely associated with amyloid plaques than tau tangles, measured with PET. jamanetwork.com/journals/jaman… 1/n

📢 Exciting times for the #Alzheimers field and some hope for patients and their caregivers A summary of the data presented today at #CTAD22 @CTADconference and @NEJM on #Lecanemab , some context and a personal view (please excuse any error) 1/n

Excited that our new paper is now out in @alzdemjournals where we show that increased brain network segregation is linked to attenuated tau spreading in Alzheimer's disease. alz-journals.onlinelibrary.wiley.com/doi/epdf/10.10…

Very happy to share our new work by @AnnaSteward_, out in @alzdemjournals showing that higher brain network segregation is associated with attenuated tau spreading in #Alzheimer's. This suggests that more segregated brain networks may provide #resilience against tau spreading

Happy to share our new work where we show that combining tau-PET with fMRI-derived maps of cognitive domains improves the prediction of cognitive decline and the sensitivity to detect treatment effects. Thanks to @nfranzme, @matbrendel and all co-authors! rdcu.be/cZcf9

Very happy that our paper is now out in @AlzheimersRes where we show that higher levels of #myelin are associated with higher resistance against #tau pathology in #AlzheimersDisease. Many thanks to @MichaelEwers12 @nfranzme @biofinder_study and others! alzres.biomedcentral.com/articles/10.11…

Many thanks to @alzforum for highlighting our work, summarizing collaborative studies on tau spreading from @alexa_pichetb, @OskarHansson9, @davinabiel, @LFrontzkowski, @MichaelEwers12, @AnnaRubinski and many others!

Check out our new preprint, showing that earliest Abeta abnormalities are associated with a sTREM2-related microglial response, which may drive p-tau elevations. Many thanks to @nfranzme, @matbrendel and @M_SuarezCalvet and all other co-authors! medrxiv.org/content/10.110…

Very happy to share our new @NatureComms paper, showing that earlier #Alzheimer's onset is associated with stronger tau in globally connected hubs, and that tau in hubs leads to faster connectivity-mediated tau spreading and cognitive decline doi.org/10.1038/s41467… 1/5

If you are interested in microglial activation and AD progression, check out our talk that is now online at @AAIC! Big thanks to @nfranzme for stepping in today for me in San Diego!

On the way to San Diego for #AAIC2022! Looking forward to a great week and seeing many of you again in person after almost three years. Also, check out our labs presentations by @AnnaDewenter @AnnaSteward_ @davinabiel and @roemersebastian

Very happy to share our new work out in @Brain1878, studying the contribution of #Alzheimer's and #SmallVesselDisease on white-matter diffusion changes using fixel-based analysis. Great work by PhD student @AnnaDewenter co-led with @MarcoDuering! doi.org/10.1093/brain/…

🔴Paper alert🔴 This took a lot of time and effort but happy to share it. We found that altered CSF biomarkers of #amyloid, #tau, and #glial response were associated with higher volumes of grey matter and increased glucose metabolism in early #Alzheimer academic.oup.com/braincomms/art…

Giving back is important! As an alumnus of the @UniBremen Neuroscience Master Program, I decided to take an action and connect the alumni to the new students, who had a hard time seeing their next steps due to a lack of practical training during the COVID19 pandemic 1/n

In case you missed @nfranzme's and my talk at the @ADPD2022 you can find it online at adpd.kenes.com/virtual-login/