still believe that solving homelessness is the true turing test ASI
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Debesh Mandal
2.9K posts
Debesh Mandal
@debesh
Co-founder and CEO @nanograb (YC S23)
London Katılım Ocak 2012
1.6K Takip Edilen428 Takipçiler
Cool analogy as to why bioML is extremely hard
"When goals are rare and 10 players share the credit, nobody can tell what they did right"
Rare events are a complete mess to optimise, predict or simulate - needs a human touch (currently) to reach activation
Faizan@faizan_a1
Pure trial and error failed completely: the team never scored once. When goals are rare and 10 players share the credit, nobody can tell what they did right. So step one was copying: the network learned by imitating a hand-coded team that already knew how to play.
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Scribe Tx's IPO is when the rubber meets the road for early stage listings
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Debesh Mandal retweetledi
The Gene Editing revolution has only just begun. Here is JD Vance describing to Joe Rogan how the first ever approved CRISPR Gene Editing therapy - $VRTX & $CRSP CASGEVY has successfully cured Sickle Cell disease. Today’s FDA approval is another milestone in this revolution! $XBI
Yair Einhorn@yaireinhorn
1/@VertexPharma have announced today that the FDA has approved expanded use of CASGEVY 🧵👇- $VRTX & $CRSP first-ever approved CRISPR Gene Editing therapy for treating Sickle Cell disease and transfusion-dependent beta thalassemia, for the treatment of people ages 2 years and older with either sickle cell disease (SCD) with recurrent vaso-occlusive crises (VOCs) or transfusion-dependent beta thalassemia (TDT). CASGEVY is the first approved genetic therapy indicated for children as young as 2 years for both SCD and TDT which means that Approximately 5,500 additional children in the U.S. are now eligible for this one-time therapy - expanding upon a prior FDA approval in people 12 years and older. $XBI
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I spent hours doing this in my first job as a barback in a cocktail bar
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Strong believer that interstellar travel will be driven by biological compute combined with biological von Neumann probes
Eben Bayer@ebenbayer
Mycelium Chips? No, not the kind you eat. the kind funded by DARPA that do inference based on the grown structure of mycelium. its a cyborg onramp
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Oh yeah lilly is gonna absolutely cook everyone. Didn't novo have a good GLP-1, I forget
Martin Shkreli@MartinShkreli
love LLY's development of brenipatide: GLP-1 for depression, alcoholism, opioid addiction, bipolar/schiz, smoking and asthma 😂
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Pretty sure there is a UK computing grad that exists somewhere who makes £128k in a day
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@Grimezsz we can put something together to slow down ovarian fibrosis
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Bruh - how can I help anyone solving this intelligently/ quickly raise?
Let me reiterate: a potential market of half the global population
If there's one thing worth throwing $ at ....
Crémieux@cremieuxrecueil
@Grimezsz @AdoptBTC @Elise_Jolene The surgical option (cut off some ovary now, put it on ice, reattach later) seems to be the only way to delay menopause that's currently available. Without an acceleration in the pace of research, most millennials will be cooked. Organ cloning + surgery could be a saving grace.
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em dash here is the best evidence of AGI
daedaulus@daedaulus
@catboosted They are making billions and funding the most important technology arguably of human history — while you are here posting about how you are “puzzled”, hiding behind an anonymous account, replying to other anonymous nobodies (i.e. ME). And yet they are “retarded”?
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@ryanstellar pretty sure YC's advice for almost 20 years has been to go and meet your customers in person, especially early on cc Brian Chesky using Airbnb for the first time, Collison Install + many others I'm sure
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Increasingly clear that we are about to have a smallpox-vaccination-like moment in healthcare over the next 20 years where one area is completely revolutionised. Seeing comments about consumer, longevity, cancer, emergency, rare disease
Could be all of them!
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I really hope the moab in moab tx stands for mother of all binders
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@paulg AI text has replaced marketing jargon but we'll become immune eventually
Yvon Chouinard nuked himself with giardia infested water to then be able to tolerate it on long climbs
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Another annoying thing about getting emails people have used AIs to write for them is that they're usually longer than they'd have written by themselves. Paragraphs and paragraphs of plausible-sounding text. Ugh.
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Insane amount of alpha if point 2 turns out not to be true
Brian Armstrong@brian_armstrong
I'd also say most biotechs are not as well run (from what I can tell). And they could learn a lot from the software industry. i.e. techbio > biotech And the 1-2 orders of magnitude complexity will get tackled with AI, not human brains. i.e. bio-naive > bio-insight driven
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@owl_posting TradBrits love talking about problems but there is a new generation who want to solve them
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after spending a few days in the UK, I’ve started to realize why the primary export of this country seems to be political commentators. you have to understand something: this whole civilization is currently sliding off into the ocean. i was not aware of this before i came here, but its no secret! citizens will actively volunteer this information to you. but none of them are scared of what awaits them. really, they bring up the whole matter to offer their opinions on it—opinions about whats causing the sliding to occur, the temperature of the water, what fish will eat their remains, and more. they will talk to you about all this with raucous laughter and glee, wine in their paws. it seems to be a national hobby, talking about the end. hence: the export. this is a little true in the US as well, but the apocalypse discussions in the UK have a sort of ‘prophetic perfect tense’ to them that feels unique to here, likely breeding a wit that would have suffered too many concussion elsewhere in the world to survive to adulthood. Edinburgh is gorgeous. it is fun that there are centuries old buildings everywhere. i went to a Vietnamese restaurant and the owner gave me free ice cream at the end of the meal
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Debesh Mandal retweetledi
A technical dive inside our new "Midjourney Scanner"
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likely only possible with synthetic biology systems heavily involved
Brian Armstrong@brian_armstrong
Should SpaceX build a von Neumann probe (self replicating spacecraft)? Potentially fastest path to explore the galaxy but without humans. It extends the light of consciousness, just not human consciousness.
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