David Rind

I'm trying to work, but he just keeps staring at me.

@AshleyGWinter My sense is that liver inflammation affects this, both from what I've heard from patients and from my own experience when I had LFTs in the 900s from mono. Eventually (many months later) my food preferences reverted to pre-mono desires.

No idea why but being hospitalized changed my food desires. I used to be a sweets person and now I just want to chug wasabi peas.

@adamcifu @susan_bewley @pash22 @MichaelBaum11 @paulpharoah @naserturabi I really enjoyed reading it! Just needed that final sequence where you realize he was John Connor's father.

@dmrind @susan_bewley @pash22 @MichaelBaum11 @paulpharoah @naserturabi Et tu David? 😉

Screening Can Do Silent Harm sensible-med.com/p/screening-ca… via Prof @adamcifu @susan_bewley @MichaelBaum11 @paulpharoah @naserturabi

@adamcifu @susan_bewley @pash22 @MichaelBaum11 @paulpharoah @naserturabi It does seem a bit like an article that only people who are already experts in what is being pointed out will understand what is being pointed out. I was waiting for the revealer final sentence that never came.

@susan_bewley @pash22 @MichaelBaum11 @paulpharoah @naserturabi I’m just realizing that. I think it might need an explainer.

@LordoftheDrugs @adamfeuerstein Glad you think so. Do you have a lot of training in preventive medicine and evaluating lipid trials?

$AMRN has not worked out well for Alex Denner.

@EM_RESUS Lack of 14g needle in the 2nd left intercostal space...

Here’s the Chest X-Ray of a young man who presented to the ER completely stable with totally normal vital signs What’s the diagnosis?

@matthewherper When the abstract reads like this, you can be pretty certain the journal's reviewers and editors told them they couldn't publish the results claiming benefit on secondary endpoints without making this point absolutely clear.

Study on Sarepta Therapeutics’ Duchenne therapy diverges from the company line statnews.com/2024/10/24/sar…

@imstephinSF @wil_da_beast630 Umm, no, it didn't show that at all.

@wil_da_beast630 Wrong. Very high spend, very little long-term outcomes data. SELECT trial in patients with cvd showed no difference in all-cause mortality at 4 years.

Good. Cuts my tax spend on health care, likely to save many lives.

@MaxJordan_N @EricTopol @KaminskiMed Yes, and, if GLP-1's really have that effect on addictive behavior, any of the many RCTs currently being run to show this will quickly stop early for benefit.

@EricTopol @KaminskiMed Seems confounded, no?

A 40-50% reduction of opioid overdose or alcohol intoxication with GLP-1 drugs among >1.3 million Americans with history of opioid or alcohol use disorders, respectively onlinelibrary.wiley.com/doi/full/10.11…

The day the Vice President was diagnosed with allergies.

@VPrasadMDMPH Look at Table 3 and you'll have the answer...

There are at least 33+ RCTs of sham vs acupuncture for pain indications and pooled together, they are negative. This is probably a bad sham or who knows? Data all from China. Has anyone seen the raw data? Editors are gullible.

Ever been frustrated by the excuse, “Sorry, it’s against hospital policy” when you needed to do something important to help someone? Well, we solved that. Get your hospital to adopt the Policy to Override Policies! jamanetwork.com/journals/jamai…

@adamcifu @RecoveryDoctor "Doing Epic" is one of Dante's circles.

I am sitting at my airplane gate, doing epic, having a coffee and a biscotti. Living the good life. #twittersuperclub @RecoveryDoctor

@rbganatra @AnilMakam @nickmmark @doc_BLocke @DrToddLee I think they must have asked experts what absolute survival advantage at one year they'd consider "important" for continuous O2 to be worth it, and they said "6%". They then looked at expected 1-year mortality and converted that to the HR needed to get 6% absolute difference.

@AnilMakam @dmrind @nickmmark @doc_BLocke @DrToddLee Yes, I am deep in the rabbit hole... But I agree, once the data exist, it's what matters. Point taken. I just don't like not understanding something (although it happens a lot)

The "nonsuperiority" thing is driving me nuts - anyone have any experience with this? What is the null hypothesis here? Cc @nickmmark @doc_BLocke @AnilMakam

@rbganatra @AnilMakam @nickmmark @doc_BLocke @DrToddLee Nice figure. Two things to consider: 1) The point estimate of 0.99 is the HR most consistent with the data; wide CI, but more O2 may well not be beneficial 2) I suspect many people would want more O2 even if it "only" reduced events by 15% (less than the first chosen threshold)

@dmrind @AnilMakam @nickmmark @doc_BLocke @DrToddLee Thanks as always for your insight, Dr. Rind! For those following along, here's what he means by changing the threshold to achieve "nonsuperiority," and that the 95% CI doesn't exclude a 28% relative reduction in the primary outcome with 24h O2 Anything wrong with the below?

@AnilMakam @rbganatra @nickmmark @doc_BLocke @DrToddLee Don't spend a lot of time worrying/thinking about non-superiority or non-inferiority. Look at the CI around the point estimate and decide if you care. More time on O2 could have believably decreased events by 28%. They had to change the threshold to make this "non-superior".

@rbganatra @nickmmark @doc_BLocke I had the same question since I've never heard of it neither has @DrToddLee who I trust x.com/DrToddLee/stat…

@adamcifu Right after one that read, "I'm hoping to have my wisdom teeth extracted again"

Would anyone else wear a t-shirt that says: I miss the schilling test?

@tedfrank Thank you! This context is very helpful.

What are Soros prosecutors? All sides, including Soros’s own words. wsj.com/articles/why-i… politico.com/story/2016/08/… heritage.org/crime-and-just… city-journal.org/article/george… policedefense.org/wp-content/upl…

@tedfrank @ProfHayward @jadler1969 Can you provide a link explaining what a "Soros prosecutor" is? Given the way that name is typically used in the US, it's understandable to be concerned that it's a trope rather than a description.

George Soros is proud of his prosecutors, and has bragged about his work getting them elected in an op-ed he wrote. It a descriptive term with an identifiable ideology. What two-word phrase conveying the concept would you prefer I use? (Disclaimer: my public interest law firm does have a lawsuit pending against the Tides Foundation for, among other things, um, conspiracy.)

I haven't investigated this case myself, but here's a thread contesting the claims that he's likely innocent. Food for thought.