Mike Dolan

🧵1/ How does the brain repair myelin after injury? We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination. biorxiv.org/content/10.110…

📢 New webinar coming soon 📢  Ozgun Gokce @ozgungokce from German Center for Neurodegenerative Diseases will be our next speaker on October 7th. Check all the information in the flyer and add it to your calendar!

I am hiring a Postdoctoral Fellow. Please share with your colleagues and feel free to reach out for an informal chat if interested.

Incredible work, congratulations @Oliver__Hahn

There's also a grant mechanism for international talent from @Researchirel to get significant start up funds to do top tier research in Ireland ! researchireland.ie/funding/global…

The Department of Genetics at Trinity College Dublin is hiring a new faculty member. Come join our lively, diverse and collaborative group of investigators. my.corehr.com/pls/trrecruit/…

@BoPengMicroglia Congratulations Bo! What an incredible study

We are proud to share our latest study published in Science. After achieving efficient and clinical feasible microglia replacement for the first time in 2020 (PMID: 32783928), we applied this strategy to treat a severe and fatal neurological disease, ALSP, and observed remarkable therapeutic effects—not only in the mouse model, but also in clinical trials involving 8 individuals with ALSP and up to 24 months of follow-up. This marks the first-in-human clinical application of microglia replacement therapy and suggesting its therapeutic effects in more neurological diseases. Check out the study at science.org/doi/10.1126/sc…

Fantastic opportunity to join and amazing lab!

Fantastic new molecular technology from @Don_B_Arnold lab.

Delighted to give a talk at the wonderful @CentreMyelin annual symposium in Cambridge, UK. Truly fantastic conference and an amazing community. Thank you to @ThoraKaradottir and @mssocietyuk for organising!

Today, we are launching the first publicly available AI Scientist, via the FutureHouse Platform. Our AI Scientist agents can perform a wide variety of scientific tasks better than humans. By chaining them together, we've already started to discover new biology really fast. With the platform, we are bringing these capabilities to the wider community. Watch our long-form video, in the comments below, to learn more about how the platform works and how you can use it to make new discoveries, and go to our website or see the comments below to access the platform. We are releasing three superhuman AI Scientist agents today, each with their own specialization: A general-purpose agent (Crow); An agent to automate literature reviews (Falcon); and An agent to answer the question “Has anyone done X before” (Owl). We are also releasing an experimental agent, Phoenix, that has access to a wide variety of tools for planning experiments in chemistry. More on that below. The three literature search agents (Crow, Falcon, and Owl) have benchmarked superhuman performance. They also have access to a large corpus of full scientific texts, which means that you can ask them more detailed questions about experimental protocols and study limitations that general-purpose web search agents, which usually only have access to abstracts, might miss. Our agents also use a variety of factors to distinguish source quality, so that they don’t end up relying on low-quality papers or pop-science sources. Finally, and critically, we have an API, which is intended to allow researchers to integrate our agents into their workflows. Phoenix is an experimental project we put together recently just to demonstrate what can happen if you give the agents access to lots of scientific tools. It is not better than humans at planning experiments yet, and it makes a lot more mistakes than Crow, Falcon, or Owl. We want to see all the ways you can break it! The agents we are releasing today cannot yet do all (or even most!) aspects of scientific research autonomously. However, as we show in the video, you can already use them to generate and evaluate new hypotheses and plan new experiments way faster than before. Internally, we also have dedicated agents for data analysis, hypothesis generation, protein engineering, and more, and we plan to launch these on the platform in the coming months as well. Within a year or two, it is easy to imagine that the vast majority of desk work that scientists do today will be accelerated with the help of AI agents like the ones we are releasing today. The platform is currently free-to-use. Over time, depending on how people use it, we may implement pricing plans. If you want higher rate limits, especially for research projects, get in touch. @m_skarlinski, @andrewwhite01, @_tnadolski, Remo Storni, @semajazarb, @ludomitch, @MichaelaThinks, as well as @jasonjoyride and his team for making such fantastic videos of us!

@TJRyan_77 @tcddublin Thank you Tomás!

A brilliant new neuroimmunology lab recruiting at @tcddublin 👇

@SoriaFN Incredible work!

We are happy to present AAV-Ncan-GFP, a genetically-encoded fluorescent probe for live #imaging of the extracellular matrix in the mouse brain. Stay tuned for the peer-reviewed version, with more insights on live #ECM monitoring by two-photon microscopy! biorxiv.org/content/10.110…

@TerufumiFujiwa1 Thanks Teru! Hope you're doing well!!

Congratulations, Mike!

9/ None of this work would be possible without the mentorship of @stevens1lab and @macosko. Or the hard work of two phenomenal RAs: Raphael Rakosi-Schmidt and Eric Garcia! Thank you to all our collaborators and coauthors!

8/ Summary: Remyelination depends on a glial-immune axis, initiated by type I interferon signaling that summons lymphocytes. Surprisingly, these cytotoxic CD8 T-cells enhance remyelination. Full story ➡️ biorxiv.org/content/10.110…

🧵1/ How does the brain repair myelin after injury? We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination. biorxiv.org/content/10.110…