Dong Li

56 posts

Dong Li

Dong Li

@dongli02

Cell biologist; Postdoc at UCSF. Interested in cell dynamics at the variable levels

San Francisco, CA Katılım Mart 2020
102 Takip Edilen26 Takipçiler
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Dong Li
Dong Li@dongli02·
Super happy to share my latest PhD paper. In this work, we uncover a novel mechanism responsible for the branched F-actin polymerization in the rear of cells. This work reveals that Arp2/3-based actin carries out a previously unappreciated function in building the rear cortex.
Journal of Cell Biology@JCellBiol

.@dongli02, Yihong Yang, Huaqing Cai et al. delineate a signaling pathway responsible for the polarized assembly of cortical F-actin in rapidly migrating cells. bit.ly/40z4mBe 🎥 See video summary by Dong Li: bit.ly/3Kdix8m #Cytoskeleton #Migration #motility

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Brisa Palikuqi
Brisa Palikuqi@BrisaPalikuqi·
We need new members to join our lab! Please share!
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Hironobu Fujiwara　藤原裕展
Hironobu Fujiwara　藤原裕展@HiroFujiwara·
Through live imaging enabled by new tools, Wuergezhen et al. visualises the hidden dynamics of the basement membrane (BM). We show how BM turnover & expansion coordinate with cellular movements & divisions, highlighting their active & synergistic roles in skin morphogenesis.
Journal of Cell Biology@JCellBiol

Wuergezhen, @hirofujiwara et al. @BDR_RIKEN reveal basement membrane (BM) dynamics in hair follicle development. By developing mice expressing fluorescently tagged Col4a2, they show how BM turnover rates guide progenitor behavior and organ shape. hubs.la/Q02_6dXr0

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Dr Naomi Moris
Dr Naomi Moris@nmoris·
Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)
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Cedric Blanpain
Cedric Blanpain@CedricBlanpain·
I am delighted to share our new study published in ⁦@NatureComms⁩ in which we uncover a common mechanism by which collagen signaling and matrix stiffness regulate stem cell multipotency in glandular epithelia. nature.com/articles/s4146…
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Dong Li
Dong Li@dongli02·
@ReiterLab It is a really interesting paper and provides a lot of information. Inspired by this paper (preprint version), I have established the primary astrocyte culture.
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Reiter Lab
Reiter Lab@ReiterLab·
Congratulations, Jiami Guo and team! I can't wait to read this interesting paper on the function of astrocyte cilia: nature.com/articles/s4159…
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Shingo Kajimura Lab
Shingo Kajimura Lab@KajimuraLab·
Tuna has an incredible capacity for mitochondrial OXPHOS in muscle. How do we study it? This is our way -- thanks to Luke Mead and Ray. Just to add, the samples are incredibly tasty.
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Muziyue Wu
Muziyue Wu@MuziyueW·
Super excited to share my thesis work! doi:biorxiv.org/content/10.110… We found how cells manage to build the extremely flat and thin membrane protrusions with the WAVE complex, that organizes into a linear polymer-like structure at the tips of lamellipodia.
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Dong Li
Dong Li@dongli02·
It is good example how alphafold helps a cell biologist understands molecular mechanisms in more depth. Another interesting observation is that Leep2 is absent from the pseudopodia during cell migration, while enriched at the MP cups, a front structure similar to pseudopodia.
Journal of Cell Biology@JCellBiol

Predicted structures of the Leep2 complex. Chao, Yang, Cai et al. (Institute of Biophysics, CAS) identify a RasGAP complex that plays a specific role in the regulation of macropinosome formation. hubs.la/Q02ClTFw0 @dongli02 #Organelles #Trafficking

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Dong Li
Dong Li@dongli02·
While the Nf1 mutation, a Ras GAP, is required to maintain high level of macropinocytosis in the axenic Dicty line, the Ras activity still needs to be optimized. This paper shows a novel RasGAP complex modulates Ras activity, which is important for macropinocytosis.
Journal of Cell Biology@JCellBiol

Xiaoting Chao, Yihong Yang, Huaqing Cai et al. identify a RasGAP complex that plays a specific role in the regulation of macropinosome formation. They demonstrate that both deletion and overexpression of this complex compromise macropinocytic activity. hubs.la/Q02Cjrxb0

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Scholarship for PhD
Scholarship for PhD@ScholarshipfPhd·
How to Write Clearly
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Brisa Palikuqi
Brisa Palikuqi@BrisaPalikuqi·
I am excited to announce that I have accepted a tenure track Assistant Professor position at the Yale Stem Cell Center and the Comparative Medicine department at the Yale Medical School.
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Shingo Kajimura Lab
Shingo Kajimura Lab@KajimuraLab·
@phillipwhite14 It is a great honor, and I am humbled to receive the Sable Award. Nothing can be accomplished without the hard work of the fellows, students, staff in my lab, and many collaborators over the years - I am so grateful. Special thanks to Phill and the Sable system for this honor.
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Phillip J White PhD
Phillip J White PhD@phillipwhite14·
Huge Congratulations to the 2024 recipient of the Sable Award, @KajimuraLab ! The award lecture was really something special
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Keşfet

@HiroFujiwara @yjgaoustc @NatureComms @lizhuoai @Nature @vonMeyenn @laurahinte @NatureNano