Aron Simkins, MD

@TheVinodLab What was the ctDNA status post op of these patients? Was it checked before chemotherapy and cancer vaccines?

2. MAJOR BARRIER for Cancer Vaccines = How DO you make anticancer T cells of HIGH   - Magnitude - Longevity - Function   Can you teach T cells to recognize “self” ➕ persist ➕ function…   in #PDAC??

#mRNAvaccines for #PancreaticCancer (PDAC) PART4 1. Out today in @Nature nature.com/articles/s4158… 🧵👇🏽 [1/23]

Waiting for two abstracts to be presented the whole @AACR #AACR26, this is one of them Just presented, #Daraxonrasib in #mKRAS #PDAC by @EileenMOReilly #Monotherapy in the #FirstLine 38 pts ORR 47% Time on tto 7.7m PFS immature Ongoing Phase III 303 (Dara vs GemNab+/-Dara)

@DrEricDing If you look at the data for the adjuvant vaccine and compared with SOC, and still think it's "remarkable" you truly don't understand oncology or clinical trials.

We finally might have a reliable treatment for pancreatic cancer after all these decades. Usually survival is 13% at year 5–but those who took the mRNA vaccine & responded to drug—almost all still alive in year 6! However, RFK Jr just cancelled billions in mRNA research funding.

Good morning! ☕️

Let's take steps together at PurpleStride! secure.pancan.org/site/TR;jsessi…

Mamdani Clarifies That His Wife Only Celebrates Terrorism In Her Capacity As A Private Citizen buff.ly/FBGKO2a

You would think the current mayor of NYC @NYCMayor would put out a statement like this one and we wouldn’t have to rely on the previous mayor.

HERIZON-GEA-01 phs-3: Zanidatamab + CTx +/- Tislelizumab in 1st line Her2+ locally advanced unresectable or mG/GEJ adenocarcinoma #ASCOGI26 👉 ORR: 70 vs 69 vs 65% 👉 mPFS: 12.4 vs 12.4 vs 8.1 mo 👉 mOS: 26.4 vs 24.4 vs 19.2 mo 👉Clinical benefit across PD-L1 subgroups 🧐 convincing data, new SOC?! @myesmo @ASCO

@GIMedOnc @JazzPharma How can this be the new SOC if it wasn't compared to a proper IO/Transtuzumab combination?

#GI26 LBA285 🔥 HORIZON-GEA-01 is presenting now. We have a new first line. Phase III, 1L HER2+ GEA Zanidatamab + chemo ± tislelizumab vs trastuzumab + chemo Key takeaways 👇 PFS significantly improved in both zanidatamab arms OS significantly improved with zanidatamab + chemo + tislelizumab Zanidatamab + chemo alone not significant at first interim Cross-trial context matters. Median OS 26.4 months here vs ~20 months in KEYNOTE-811. Zanidatamab + chemo + tislelizumab is a new 1L standard for HER2+ GEA 🚀 @OncoAlert @TheGutOncLab

@DrRishabhOnco No neoadjuvant chemoIO, Arm1 is not the SOC anymore

📊 CRITICS-II at #ASCOGI26 Total neoadjuvant therapy wins the pre-op race in resectable gastric cancer 🍽️🩺 3 strategies tested head-to-head 🧪 Chemo alone 🔥 Chemoradiation alone 🚀 Chemo ➜ Chemoradiation (TNT) What stood out 👀 📈 1-yr EFS highest with TNT (84%) vs chemo (68%) 🎯 pCR doubled with TNT (20%) ⚠️ Pre-op chemo alone missed EFS efficacy threshold 🔪 Surgery quality excellent across arms, complications acceptable 💀 In-hospital mortality low (4%) Bottom line 🧠 If the goal is deeper response + better early disease control, chemo + chemoradiation emerges as the preferred pre-operative strategy. Phase III confirmation clearly warranted. #GI26 #ASCOGI26 #GastricCancer #Oncology @oncoalert @larvol @asco

USA: not recognizing Spain in the Americas since 1898.

@nickshirleyy Thanks Nick

Seeing Venezuelans celebrating that their president has been taken tells you all you need to know Whether you liked Trumps decision or not, I wouldn’t let an American tell you how you should feel about it. Listen to the people LIVING it.

The Somali daycare fraud never happened Zohran isn’t a communist Maduro was the good guy ~~~ These are mainstream Democrat positions right now — you can see that they’re false just by opening your eyes

There’s a good reason the US and dozens of other countries and cities have adopted the IHRA definition of antisemitism. When leaders move to revoke it, like what happened today in New York, it should alarm everyone—especially as violence against Jews is dangerously escalating.

@dlLambo Kidnapping children is not "armed resistance" is terrorism.

A fact: Palestinians have a right to armed resistance under international law. A question: why does no Western nation accept this fact? Support Palestinian Resistance

One was a Holocaust. The other was not.

Never forget that hostages are being released and the war is ending—and the only reason this didn’t happen sooner is because much of the world, including “humanitarian” organizations and the UN, sided with Hamas. Never, ever forget.

High agency is believing you can learn new things and work hard to solve tough problems no matter how complicated. Low agency is sitting around making fun of people who try.

The Yevsektsiya were Jews. They blamed “Zionists” and traditional Jews for alienating Soviet society. They believed that if Jews behaved properly and complied with Communism, the regime would treat them well. When they were no longer useful, the Yevsektsiya were disbanded. Their members were executed or sent to labor camps. The Antizionist League of Iraq were Jews too. They thought Zionists were the problem. They believed that if Jews in Iraq distanced themselves from the idea of a Jewish state, all the hatred would fade away. They were wrong. The League was dissolved, its leaders imprisoned, and Iraq’s Jews were slaughtered in the Farhud and driven out. Nobody asked whether they were Zionists before burning their homes or stabbing them in the streets. A hundred years ago, Baghdad was more Jewish than New York City is today. Now there are fewer than ten Jews in the entire country. Trying to prove that you’re one of the “good Jews” never works. The same story played out in Germany. Jews there were the most assimilated in the world — cultured, loyal, and proud Germans. They thought the “bad Jews” were the Eastern European immigrants. The Association of German National Jews, who sought to align themselves with the Nazi Party, was outlawed. They were deported and burned along with the rest of European Jewry. Today, there are fewer Jews in all of Europe than there are Israeli Arabs in Israel. So much for Europe lecturing Israel about tolerance. Once a society starts stigmatizing Jews — or even just a subset of Jews — the writing is on the wall. Assimilation and appeasement do not work. Explaining ourselves kindly and hoping to be accepted as the “good ones” does not work. We are living in a dangerous time for Jews. The United States and perhaps Argentina are the last places where Jews are not broadly stigmatized. But that is changing. In a 2023 Harvard-Harris poll, two-thirds of Americans aged 18 to 24 said “Jews as a class are oppressors and should be treated that way.” That is the future of public opinion. We have no choice but to name antizionism for what it is. And we must do it now. Because if “anti-Zionism” were really about Bibi, it wouldn’t have existed before Israel was founded. And yet Jews were being slaughtered under that same banner for centuries. The truth is simple. Antizionism is a hate movement with hundreds of years of Jewish blood on its hands. It is systemic. It is global. It is deadly. Kind explanations and compliance have never saved us. Only clarity, courage, and truth have.

It is NOT a "both sides" issue. No assassination attempts on Biden. No assassination attempts on Kamala. No assassination attempts on AOC. No assassination attempts on any other prominent voice on the political left. No violence from pro-Israeli crowds. No arrests on the pro-Israeli side. No calls for death or murder of those who oppose the pro-Israeli side. Those who oppose gender ideology do not call for the death of those who disagree with them. Those who oppose movements like BLM did not call for the death of those who took part in the BLM riots. Social media is not flooded with videos from those on the right celebrating the deaths of those on the left or wishing harm upon them. It is not a "both sides" issue.